CHEN, YIJUN

Release date:2016-05-13  Release:



CHEN, YIJUN

Professor of Chemical Biology

School of Life Science & Technology

Phone: +86-25-83271045

Email: yjchen@cpu.edu.cn

Research Summary

The research of Dr. Chen’s group focuses on the elucidation and manipulation of biosynthetic pathways for microbial secondary metabolites, development of unique biocatalytic routes for chiral drug intermediates, discovery of novel enzymes and mechanistic study on their catalytic mechanisms and structure-function relationship and discovery of novel antitumor targets using chemical proteomics approach.

Education

1996       Ph.D., Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, USA

1982       B.S., Pharmaceutical Science, China Pharmaceutical University, China

Academic Experience

2007- Professor & Director of Chemical Biology, China Pharmaceutical University

2010-  Adjunct Professor, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, USA

1999-2006 Research Investigator & Senior Research Investigator, Bristol-Myers Squibb Company, USA

1998-1999 Senior Scientist, MicroGenomics, Inc, USA

1997-1998 Postdoctoral Research Associate, University of California at San Diego, USA

1992-1996 Research Assistant, University of Iowa, USA

1991-1992 Visiting Scholar, Texas A&M University, USA

1986-1990 Engineer, Aquatic Institute of Suzhou

1982-1986 Assistant Engineer, Aquatic Institute of Suzhou

Awards and Honors

2015 “The Friendship Award” by the Central Government of China

2013Member of “1000 Plan for Recruitment Program of Global Talents” by the Central Government of China

2012   Outstanding Achievement Award in Innovation by All-China Federation of Returned Overseas Chinese

2010   Outstanding Foreign Expert recognized by the State Administration of Foreign Expert Affairs of China  

2010   Member of High-Level Innovation and Entrepreneurship Talent Program by Jiangsu Province

PublicationsSelected representatives

1. Wang, S.Z., Xie, W.Q., Wang, D.W., Peng, Z.G., Zheng, Y., Liu, N., Dai, W., Wang, Y., Wang, Z.Q., Yang, Y.* & Chen, Y.J.* Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia. Oncotarget2015, 6(14), 12128-12140.

2. Ma, M., Xue, Y.J., Liu, W.Y., Zhang, H., Kong, L.Y., Wang, S.Z.*, Chen, Y.J.* Directly utilizing an endogenous gene to dissect regulatory elements in the biosynthetic gene cluster of nosiheptide. Chem. Commun.2014, 50(53), 7004-7006.

3. Wang, Z.Q., Shi, C., Wu, X.R., Chen, Y.J.* Efficient access to the non-reducing end of low molecular weight heparin for fluorescent labeling. Chem. Commun.2014, 50(53), 7004-7006.

4. Zhang, J.L., Tao, S.S., Zhang, B.J., Wu, X.R, Chen, Y.J.* Microparticle-based strategy for controlled release of substrate for the biocatalytic preparation of L-homophenylalanine. ACS Catal.2014, 4(5), 1584-1587.

5. Liu, W.Y., Ma, M., Xue, Y.J., Liu, N., Wang, S.Z.* & Chen, Y.J.* The C-terminal extended serine residue is absolutely required in nosiheptide maturation. ChemBioChem  2013, 14(5), 573-576.

6. Lu, M.L., Huang Y., White, M.A., Wu, X.R., Liu, N., Cheng, X.D.* & Chen, Y.J.* Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase. Chem. Commun.2012, 48(92), 11352-11354.

7. Chen, Y.J.*, Chen, C. & Wu, X.R. Dicarbonyl reduction by single enzyme for the preparation of chiral diols. Chem. Soc. Rev.2012, 41 (5), 1742-1753.

8. Wu, X.R., Jiang, J.P. & Chen, Y.J.* Correlation between intracellular cofactor concentrations and biocatalytic efficiency: coexpression of diketoreductase and glucose dehydrogenase for the preparation of chiral diol for statin drugs. ACS Catal.2011, 1 (12), 1661-1664.

9. Wu, X.R., Chen, C., Liu, N. & Chen, Y.J.* Preparation of ethyl 3R, 5S-6-(benzyloxy)-3, 5-dihydroxy-hexanoate by recombinant diketoreductase in a biphasic system. Bioresour. Technol.2011, 102 (3), 3649-3652.

10. Wei, M.C., Deng, J., Feng, K., Yu, B.Y. & Chen, Y.J.* Universal method facilitating the amplification of extremely GC-rich DNA fragments. Anal. Chem.2010, 82 (14), 6303-6307.