GUO, WEI

Release date:2016-05-13  Release:





GUO, WEI

Associate Professor of Microbial and Biochemical Pharmacy

School of Life Science and Technology

Phone: 86-25-83271544

Email: guowei1205@cpu.edu.cn

Research Summary

Associate Professor Guo is working in Department of Molecular biology. Her research focuses on:

(1)Mechanistic study on influence factors during T cell differentiation and development in AID,

(2)Biological molecular design and protein drug development based on cytokine and T cell misbalance in AID,

(3)Strategies and methods on T cell immunotherapy

Education

2012  Ph.D., Microbial and Biochemical Pharmacy, China    

Pharmaceutical University

2004  M.S., Microbial and Immunology, Southeast University

2001  B.S.,  Clinical Medicine, Jiangsu University

Academic Experience

2014-now      Associate Professor of Microbiology & Biochemical Pharmacy, China Pharmaceutical University

2007-2014     Lecturer of Microbiology & Biochemical PharmacyChina Pharmaceutical University

Awards and Honors

2015 Teaching Excellence Award by Shanghai Fosun Pharmaceutical Group,

2014High-Level Talents in Six Industries, The Government of Jiangsu Province

Publications (in recent 5 years)

1. Wei Guo, Dongmei Yu, Xin Wang, Cheng Luo, Yucong Chen, Wen Lei, Chen Wang, Yaoyao Ge, Wenyao Xue, Qiqi Tian, XiangdongGao*, Wenbing Yao*. Anti-inflammatory effects of Interleukin-23 Receptor Cytokine-binding Homology Region rebalance T cell distribution in rodent collagen-induced arthritis. Oncotarget, 2016, in press

2. Wei Guo#, Chen Wang#, Xin Wang, Cheng Luo, Dongmei Yu, Yuheng Wang, Yucong Chen, Wen Lei, Xiangdong Gao*, Wenbing Yao*. A novel human truncated IL12rβ1-Fc fusion protein ameliorates experimental autoimmune encephalomyelitis via specific binding of p40 to inhibit Th1 and Th17 cell differentiation. Oncotarget, 2015, 6(30):28539-28555. (# equal contribution)

3. Wei Guo#, Cheng Luo#, Chen Wang, Yuheng Wang, Xin Wang, Xiangdong Gao*, Wenbing Yao*. Suppression of human and mouse Th17 differentiation and autoimmunity by an endogenous Interleukin 23 receptor cytokine-binding homology region. Int. J. Biochem. Cell Biol., 2014, 55:304-310. (# equal contribution;*corresponding author)

4. Wei Guo#, Luo Cheng#, Chen Wang, Yue Zhu, Xin Wang, Xiangdong Gao*, Wenbing Yao*. Protection against Th17 Cell Differentiation by an interleukin-23 receptor cytokine-binding homology region. PLoS One, 2012, 7(9):1-10. 5.

5.Chen Wang, Wei Guo, Di Cai, Xin Wang, Dongmei Yu, Xiangdong Gao*, Wenbing Yao*. A truncated IL-12rb1 receptor ameliorates chronic graft-versus-host disease-induced lupus nephritis by inhibiting Th1 and Th17 cells. Int. Immunopharmacol., 2015, 29(2):544-551.