HE, SHUYING

Release date:2016-05-13  Release:



HESHUYING, Ph.D.

Associate Professor of Biochemical Pharmacology

Director of Experiment Teaching Center of Biopharmaceuticals

School of Life Science and Technology

Phone: 86-25-86185219

Email: shuyinghe66@gmail.com


Research Summary

Professor HE’s research focuses on drug screening of anti-atherosclerosis and its mechanisms, which involving cell culture technologyPCR technologywestern technologyimmune-histochemical techniqueimmune co-precipitation technologygene knock outprotein preparation and purification technology, etc. She Engaged in the research of new targets of atherosclerosis with the support of foundation of China Scholarship Council(CSC) in the university of Michigan in Ann arbor from 2012 to 2013.She published more than 20 research papers in the recent years, and the following is the published SCI papers :Life Sciences (2005; 77 (8) : 907-921)European Journal of Pharmacology (2007,554:191-195)Chinese Chemical Letters (2011, 22:413-416)Vascular and Endovascular Surgery (2012 46-48 (5), 393-400)Cardiovascular Drugs and Therapy (2012, 26 (6) : 479-488)Vascular and Endovascular Surgery (2014, 48 (4), 289-296)Oncology Letters, 2016, 11:491-2016.

EDUCATION

2004   Ph.D., Pharmacology, China Pharmaceutical University

1991   M.S., PharmaceuticalBiochemistry, China Pharmaceutical University

1988   B.S., Medicinal chemistry, China Pharmaceutical University


WORKING EXPERIENCE

2012.3-2013.3 visiting scholar, University of Michigan (Ann Arbor)   

2004-presentassociate professor,ChinaPharmaceuticalUniversity

1996-2001     Seniorengineer, NanjingNandaPharmaceuticalCo. Ltd.

1991-1995     engineer, Nanjing No2 Pharmaceutical Factory

AWARDS AND HONORS


2015   The third prize of Small Class Teaching Competition in Jiangsu Province, Education Department of Jiangsu Province

2010   Third Place/National Excellent Teaching Team, Education Ministry of China

2008Foundation of Top-Level Talents on Six Fields in Jiangsu Province, Personnel Department of Jiangsu Province

PUBLICATIONS (*corresponding author)

  1. RUI XIONG, JING SUN, KUN LIU, YUNGEN XU and SHUYING HE*. Effect of CPU-XT-008, a combretastatin A-4 analogue, on the proliferation, apoptosis and expression of vascular endothelial growth factor and basic fibroblast growth factor in human umbilical vein endothelial cells. Oncology Letters, 2016,11: 491-499.

  2. Danfeng Yu, Xue Rui, Shuying He*.Effect of Heparin-Derived Oligosaccharide on bFGFR1 and bFGFR2 in Vascular Smooth Muscle Cells. Vascular and Endovascular Surgery. 2014, Vol. 48(4) 289-296.

  3. LI Li, GAO Ting, HE Shu-ying*, XU Guang-lin, YANG Li-na. Effect of heparin-derived oligosaccharide on vascular smooth muscle cell proliferation through inhibition of PKC-α expression. Acta Pharmaceutica Sinica 2012, 47 (8): 993−1000.

  4. Li Li, Wei Li, Zhong Ren, ShuYing He*, GuangLin Xu, and LiNa Yang. Effect of Heparin-Derived Oligosaccharide on Vascular Smooth Muscle Cell Proliferation. Vascular and Endovascular Surgery.2012,46(5) 393-400.

  5. Li Li, Xue Rui, Tongfei Liu, Guanglin Xu, Shuying He*. Effect of Heparin-Derived Oligosaccharide on Vascular Smooth Muscle Cell Proliferation and the Signal Transduction Mechanisms Involved. Cardiovascular Drugs and Therapy.2012,26(6): 479-488.

  6. HE Shu-ying, GAO Ting, XU Guang-Lin. The Preparation of Heparin-Derived Oligosaccharides through Gradient gel Electrophoresis. Pharm Biotechno, 2011, 18(5):426-429.

  7. Li Chen , Wen Qiu , Jia Tang , Zhi Feng Wang , Shu Ying He*. Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives. Chinese Chemical Letters, 2011,22:413–416

  8. LI WeiCHEN Li-pingLI LiXU Guang-linHE Shu-ying* .Effect of twelve  degree of polymerization heparin proliferation in vascular smooth muscle cells. Chin J Clin Pharmacol T her 2011 Aug ; 16( 8).

  9. CHEN Li-Ping, HE Shu-Ying*, ZHENG Heng, DAI Yu-Lu. Effects and Mechanisms of lycopene on the proliferation of vascular smooth muscle cells. Chin J Nat Med, 2010, 8(3): 0218−0222.

  10. PENG Chen, GE Hao, HE Shuying, GAO Xiangdong*. Molecular cloning, expression and identification of recombinant hyaluronan synthase from Pasteurellamultocida. J China Pharm Univ,2009, 40 (6) : 549 – 552.

  11. XIE Wei, HE Shuying*, YANG Penghui, ZHANG Xia, DIGN Feng. Preparation of compound vitamin B6 sustained release capsules and their quality control. Progress in Pharma Sci,20093312559-563.

  12. NIU Jia, HE Shuying*, LI Wei, WANG Lirong. Preparation of heparin-derived oligosaccharides and effection of them on vascular smooth muscle cells prol iferation. Pharm Biotechno,2009 ,16 (1) :046049.

  13. CHEN Li -ping, HE Shu–ying*. Antioxidation activity of lycopene. West China J Pharma.2008, 23 (6):653655.

  14. LIU Ya-mei , HE Shu-ying , WU Wu-tong*. Enzymatical preparation and activities research of Low Molecular Weight Heparin. Pharm Biotechno,2007 ,14 (4) :277280.

  15. Shu-Ying He, Zhi-Yu Qian , Na Wen , Fu-Tian Tang, Guang-Lin Xu, Cheng-Hua Zhou .Influence of Crocetin on experimental atherosclerosis in hyperlipidamic-diet quails. Eur J Pharmacol. 554 (2007) 191–195.

  16. HE Shu-ying, LI Hua, YANG Ning. Purification of the low molecular weight heparin by affinity chromatography. Chin J biochem pharm.200627(3)170171.

  17. HE Shu-ying, QIAN Zhi-yu. Protective effects of crocin on cultured calf aortic endothelial cells injured by low-density lipoproteins.West China J Pharma.2006211):028031.

  18. Shu-Ying He, Zhi-Yu QianT, Fu-Tian Tang, Na Wen, Guang-Lin Xu, Liang Sheng. Effect of crocin on experimental atherosclerosis in quails and its mechanismLife Sci. 200577 (8)907–921.

  19. HE Shu-ying, QIAN Zhi-yu. Protective effects of crocin on cultured calf aortic endothelial cells injured by Ox- LDL. Chin J of new drug.2005142):169173,

  20. HE Shu-Ying, QIAN Zhi-Yu*, TANG Fu-Tian. Effect of crocin on calcium concentration in cultured bovine aortic smooth muscle cells. Acta Pharm Sin. 20043910):778—781.

  21. HE Shu-Ying, QIAN Zhi-Yu, XU Guang-Lin. Studies on the Antiproliferative effect of Crocin and its mechanism. J China Pharm Univ.2004,35(1):6568.

  22. HE Shuying,Wu Huirong, Zhang Wanwen, Zhang hui, Lu Fengxiang, Huang Yuantao. Comparison between China-made and exported LMWH in treating unstabale angina pectories . Chin J Biochem Pharm.2000,212):88-89.