KONG, YI

Release date:2016-05-13  Release:


KONG, YI

Associate Professor of Microbiology and Biopharmaceuticals

School of Life Science and Technology

Phone: 86-25-83271282

Email: yikong668@163.com

Research Summary

Professor KONG’s research focuses on the discovery of novel bioactive peptides for the treatment of cardiovascular disorders. They take ocean creatures and traditional Chinese animal medicines as sources for the discovery of natural bioactive peptides, and isolate and purify peptides from them by using membrane separation technology and chromatography technology, and test bioactivities of these peptides both in vitro and in vivo using ELISA, enzymology analysis and animal models. They also explore the molecular action mechanism of some potential drug-like peptides.

Education

1998      Ph.D., Medicine Analysis, China Pharmaceutical University.

1995       M.S.,  Plant NutritionNanjing Agriculture University

1990       B.S.,   PharmacyShenyang Pharmaceutical University

Academic Experience

2013- Present     Associate Professor of Microbiology and Biopharmaceuticals, China Pharmaceutical University

2001-2003  Post-doc of BiologyNanjing University

2012-2013  Visiting Scholar, University of North Carolina

Awards and Honors


Publications

2015

Mei-Mei Chen, Xiao-Hui Ye, Xin Ming, Ya-Hui Chen, Ying Wang, Xing-Li Su, Wen Su and Yi Kong. A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates[J]. Scientific reports, 2015, 5.

Yi Kong, Ying Wang, Wei Yang, Zhou-Ling Xie, Zhi-Yu Li. LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa[J]. Journal of pharmacological sciences, 2015, 127(4): 462-466.

Xing-Li Su, Wen Su, Zhi-Long He, Xin Ming and Yi Kong. Tripeptide SQL Inhibits Platelet Aggregation and Thrombus Formation via Affecting PI3K/Akt Signaling[J]. Journal of cardiovascular pharmacology, 2015, 66(3): 254-260.

Xiao-Hui Ye, Mei-Mei Chen, Ya-Hui Chen, Xing-Li Su, Ying Wang, Wen Su, Yi Kong. Isolation and Characterization of a Novel Antithrombotic Peptide from Enzymatic Hydrolysate of Agkistrodon acutus Venom[J]. International Journal of Peptide Research and Therapeutics, 21(3): 343-351.

Guangyan Cheng, Liying He, Zhibin Sun, Zhongli Cui, Yingxiang Du, Yi Kong. Purification and biochemical characterization of a novel fibrinolytic enzyme from Streptomyces sp. P3[J]. Journal of microbiology and biotechnology, 2015, 25(9): 1449–1459.

Yahui Chen, Ying Wang, Zhouling Xie, Xin Ming, Zhiyu Li, Yi Kong. A tryptophan derivative TD-26 attenuates thrombus formation by inhibiting both PI3K/Akt signaling and binding of fibrinogen to integrin αIIbβ3[J]. Biochemical and Biophysical Research Communications, 2015, 465: 516-522.

Caihui Wang, Wen Su, Xingli Su, Guojun Ni, Tao Liu, and Yi Kong. Synergy Effects of Three Plant Extracts on Protection of Gastric Mucosa[J].Natural Product Communications, 2015, 10(11): 1989-1991.

Zhouling Xie, Sen Feng, Ying Wang, Chen Cao, Jing Huang, Yahui Chen, Yi Kong, Zhiyu Li. Design, synthesis of novel tryptophan derivatives for antiplatelet aggregation activity based on tripeptide pENW (pGlu-Asn-Trp) [J]. European Journal of Medicinal Chemistry, 2015, 102: 363-374.

Zhibin Sun, Weihao Lu, Pingping Liu, Hui Wang, Yan Huang, Yuguo Zhao, Yi Kong, Zhongli Cui. Isolation and characterization of a proteinaceous α-amylase inhibitor AAI-CC5 from Streptomyces sp. CC5, and its gene cloning and expression[J]. Antonie van Leeuwenhoek, 2015, 107:345–356.


2014

Yi Kong, Cheng Xu, Zhi-Long He, Qiu-Mei Zhou, Jin-Bin Wang, Zhi-Yu Li, Xin Ming. A novel peptide inhibitor of platelet aggregation from stiff silkworm, Bombyx batryticatus[J]. Peptides, 2014, 53: 70-78.

Yi Kong, Shuai Li, Yu Shao, Zhi-Long He, Mei-Mei Chen, Xin Ming, Ji-Fu Wei. Antithrombotic Peptides from Scolopendra subspinipes mutilans Hydrolysates[J]. International Journal of Peptide Research and Therapeutics, 2014, 20(2): 245-252.

Yi Kong, Hao Chen, Yong-Qing Wang, Ling Meng and Ji-Fu Wei. Direct thrombin inhibitors: Patents 2002-2012 (Review)[J]. Molecular medicine reports, 2014, 9(5): 1506-1514.

Hao Chen, Min Jin, Yi-Fen Wang, Yong-Qing Wang, Ling Meng, Rong Li, Jia-Ping Wang, Li Gao, Yi Kong and Ji-Fu Wei. Effect of Toona microcarpa Harms Leaf Extract on the Coagulation System[J]. BioMed research international, 2014


2013

Yi Kong, Yu Shao, Hao Chen, Xin Ming, Jin-Bin Wang, Zhi-Yu Li, Ji-Fu Wei. A novel factor Xa-inhibiting peptide from centipedes venom[J]. International journal of peptide research and therapeutics, 2013, 19(4): 303-311.

Yi Kong, Jing Hui, Yu Shao, Shi-Long Huang, Hao Chen and Ji-Fu Wei. Cytotoxic and anticoagulant peptide from Scolopendra subspinipes mutilans venom[J]. African J Pharm Pharmacol, 2013, 7: 2238-2245.

Yi Kong, Shi-Long Huang, Yu Shao, Shuai Li, Ji-Fu Wei. Purification and characterization of a novel antithrombotic peptide from Scolopendra subspinipes mutilans[J]. Journal of ethnopharmacology, 2013, 145(1): 182-186.


2012

Jing Xiong, Li Bai, Wei Fang, Jianyang Fu, Weirong Fang, Juan Cen, Yi Kong, Yunman Li. New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation[J]. European Journal of Pharmaceutical Sciences, 2012, 45(5): 552-558.


2011

Hongwen Zhao, Yi Kong, Hanjin Wang, Tianhua Yan, Feifei Feng, Jianmin Bian, Yan Yang and Haining Yu. A defensinlike antimicrobial peptide from the venoms of spider, Ornithoctonus hainana[J]. Journal of Peptide Science, 2011, 17(7): 540-544.