QIU, ZHENG
Associate Professor of Microbiology and Biochemical Pharmacy
School of Life Science and Technology
Phone: 86-15005162283
Email: 1020081856@cpu.edu.cn
Research Summary
Qiu’s research focuses on antitumor area including antitumor antibody and peptide. Her team designed a bifunctional antitumor peptide based on its inhibition of MMP-9 activity and anti-angiogenesis. This peptide could inhibit B10F16 tumor growth in C57BL/6 mice. Further mechanism studies on this peptide are going on. They also use phage display technical to screen single chain antibodies and peptides targeting several tumor targets.Now they are working on projects targeting folate receptor alpha and PD1.
Education
2014 Ph.D., Microbiology and Biochemical, China Pharmaceutical University
2002 M.S., Pharmaceutical Science, University of Leuven, belgium
2000 M.S., Microbiology and Biochemical, China Pharmaceutical University
1996 B.S., Pharmacy andHerbology Henan University of Traditional Chinese Medicine
Academic Experience
2014- Associate Professor of Microbiology and Biochemical Pharmacy, China Pharmaceutical University
2008-2013 Lecturerof Microbiology and Biochemical Pharmacy, China Pharmaceutical University
Publications
1 Qiu Z, Zhang F, Gong C, Xu H, Hu J. Fusion Peptides CPU1 and CPU2 Inhibit Matrix Metalloproteinases and Protect Mice from Endotoxin Shock Within a Strict Time Window. Inflammation. 2015,38(6):2092-104
2.Qiu Z, Chen J, Xu H, Van den Steen PE, Opdenakker G, Wang M, Hu J.Matrix metalloproteinases inhibiting peptide P2 protects mice from endotoxin shock. Journal of Immunology Research. 2014;2014:747426.
3.Qiu Z, Hu J, Xu H*, Wang W, Nie C, Wang X. Generation of anti-tumor peptides by connection of matrix metalloproteinase-9 peptide inhibitor to an endostatin fragment. Anti-Cancer Drugs.2013, 24:677-689.
4.Qiu Z, Hu J, Van den Steen PE, Opdenakker G*. Targeting matrix metalloproteinases in acute inflammatory shock syndromes. Comb Chem High Throughput Screen. 15(7):555-70，2012.
5.Qiu Z, Yan M, Li Q, Liu D, Van den Steen PE, Wang M, Opdenakker G, Hu J*. Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-α converting enzyme (TACE/ADAM-17). J Enzyme Inhib Med Chem. 27(4):533-40，2012.
