WU, XURI

Release date:2016-05-13  Release:

 

 

 

Wu, XURI

Associate Professor of Microbial and Biochemical Pharmacy

 

School of Life Science and Technology

Phone: 86-25-83271031

Email:xuriwu@cpu.edu.cn

Research Summary

ProfessorWu is currently concentrating on the researches ofunderstanding the fundamental mechanisms and pathways involved in production of antibioticsand other bioactive natural products in bacterium, with aparticular emphasis onStreptomyces. On the other hand, the biosynthesis and bio-production of drugs and/or intermediates using enzymological and microbiological technique isanother field oftheexpertise for him.He recentlystudied on the biosynthetic pathway and regulatorymechanism of thiopeptideantibiotics including nosiheptide andnocathiacin, whichdisplay excellent antibacterial activities against multidrug-resistant bacterial pathogens. In addition, He builta chem-ezymatictechnique for the green synthesis ofrosuvastatin calcium (Crestor) by a unique diketoreductase.

 

Education

2006-2011       Ph.D.,Microbial and Biochemical PharmacyChina Pharmaceutical University

2002-2006       B.S., TraditionalChinese MedicineAnhuiCollegeof Chinese Medicine

Academic Experience

2015-    Associate Professor of theMicrobial and Biochemical Pharmacy,China Pharmaceutical University

2011-2015   Senior Research Scientist of theMicrobial and Biochemical PharmacyChina Pharmaceutical University

Awards and Honors

2011  “Johnson & Johnson Asia Outstanding Graduate Thesis Award in Bio-tech”

Selected Publications

[1]Wu X.R., Gou X.D., Chen Y.J.* Enzymatic preparation of t-butyl-6-cyano- (3R,5R)-dihydroxyhexanoate by a whole-cell biocatalyst co-expressing carbonyl reductase and glucose dehydrogenase. Process Biochem., 2015, 50: 104-110. (IF = 2.516)

[2] Wu X.R., Fei M.D., Chen Y., Wang Z.Q., ChenY.J.* Enzymatic synthesis of L-norephedrine by coupling recombinant pyruvate decarboxylase and ω-transaminase. Appl. Microbiol. Biotechnol., 2014, 98: 7399-7408. (IF = 3.337)

[3] Zhang J.L., Zhu T.Y., Wu X.R.*, Chen Y.J.*Enhancement of biocatalytic efficiency by increasing substrate loading: enzymatic preparation of L-homophenylalanine,Appl. Microbiol. Biotechnol.,2013, 97: 8487-8494. (IF = 3.337)

[4] Chen Y.J.* Chen C., Wu X.R.Dicarbonyl reduction by single enzyme for the preparation of chiral diols,Chem. Soc.Rev.,2012, 41: 1742-1753. (IF = 33.383)

[5]Wu X.R., Jiang J.J., Chen Y.J.*Correlation between intracellular cofactor concentrations and biocatalytic efficiency: Co-expression of diketoreductase and glucose dehydrogenase for the preparation of chiral diol for statin drugs,ACS Catal.,2011, 1: 1661-1664.(IF = 9.312)

[6]Wu X.R., Chen C., Liu N., Chen Y.J.* Preparation of ethyl 3R, 5S-6-(benzyloxy)-3, 5-dihydroxy-hexanoate by recombinant diketoreductase in a biphasic system,Bioresoure Technol.,2011, 102: 3649-3652.(IF = 4.494)