HE, HUA

Release date:2016-05-17  Release:




HE, HUA

Professor of Pharmaceutical Analysis

School of Science

Phone: 86-25-86185150

Email: dochehua@163.com

Research Summary

Professor HE’s research focuses on the design and application of new polymeric materials in all areas of analytical science, in particular separation scienceand drug quality research. He recently published two papers entitled " Development of novel amphiphilic magnetic molecularly imprintedpolymers compatible with biological fluids for solid phase extractionand physicochemical behavior study"  and "Mixed hemimicelles solid-phase extraction based on ionicliquid-coated Fe3O4/SiO2 nanoparticles for the determination offlavonoids in bio-matrix samples coupled with high performanceliquid chromatography" which include the studies of novelproperties of materials such as functionalized nanoparticles fordeveloping nanoscale biochemical analysis methods and molecularimprinting-based sample pretreatment technology.

Education

2003       Ph.D., Environment Science, Nanjing University

1988       M.S.,  Pharmaceutical AnalysisChina Pharmaceutical University

1983       B.S.,  Analytical ChemistryAnhui University


Academic Experience

2006-      Professor of Pharmaceutical Analysis, China Pharmaceutical University


Awards and Honors

2013       Chief expert (Engineer) Jiangsu Province Science and Technology Association


Publications

Books

Hua He, Kunyi Ni,Modern Chromatographic Analysis, Beijing: Chemical Industry Press, 2004

Hua He, Biological Drug Analysis, Beijing: Chemical Industry Press, 2014


Papers and Articles

2016

Man Qi#, Kai Zhang, Siqiao Li, Jianrong Wu, Chuong Pham-Huy, Xintong Diao, Deli Xiao*, Hua He*Superparamagnetic Fe3O4 nanopartcles: synthesis by solvothermal process and functionalization for a magnetic targeted curcumin delivery system[J]. New Journal of Chemistry, 2016, DOI: 10.1039/C5NJ02441B

Deli Xiao#, Siqiao Li, Shubo Liu, Hua He*, Jinrong Lu, One-step hydrothermal synthesis of photoluminescent carbon nitride dots derived from ionic liquids[J]. New Journal of Chemistry, 2016, 40(1): 320-324.

Sumei Kong#, Ming Liao, Yu Gu, Nan Li, Pinping Wu, Tingting Zhang, Hua He*Colorimetric recognition of pazufloxacin mesilate based on the aggregation of gold nanoparticles [J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2016, 157: 244-250.

Jun Peng#,Deli Xiao#, Hua He*, Hongyan Zhao, Cuixia Wang, Tian Shi, Kexin Shi, Molecularly imprinted polymeric stir bar: Preparation and application for the determination of naftopidil in plasma and urine samples[J]. Journal of Separation Science, 2016, 39 (2), 383–390.

Hongyan Zhao#, Manyan Huang, Jianrong Wua, Li Wang, Hua He*, Preparation of Fe3O4@PPy magnetic nanoparticles as solid-phase extraction sorbents for preconcentration and separation of phthalicacid esters in water by gas chromatography–mass spectrometryJournal of Chromatography B, 2016101133–44

Pengli Zuo#, Junfa Gao, Jun Peng, Jianha Liu, Mingming Zhao, Jiahong Zhao, Pengjian Zuo, Hua He*, A sol-gel based molecular imprint incorporating carbon dots for fluorometric determination of nicotinic acidMicrochim Acta 2016183:329–336


2015

Deli Xiao#, Cuixia Wang#, Hao Dai, Jun Peng, Jia He, Kai Zhang, Sumei Kong, Panzi Qiu, Hua He*Applications of magnetic surface imprinted materials for solid phase extraction of levofloxacin in serum samplesJ. Mol. Recognit. 2015; 28: 277–284

Deli Xiao#, Renfeng Pan#, Siqiao Li, Jia He, Man Qi, Sumei Kong, Yu Gu, Rui Lin*, Hua He*Porous carbon quantum dots: one step green synthesis via L-cysteine and application in metal ions detectionRSC Adv., 2015, 5, 2039–2046

Nan Li#, Yu Gu, Mengmeng Gao , Zilu Wang , Deli Xiao , Yun Li , Rui Lin , Hua He*Colorimetric determination of o-phenylenediamine in water samples based on the formation of silver nanoparticles as a colorimetric probeSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2015, 1405):328–333

Yu Gu#, Nan Li, Mengmeng Gao, Zilu Wang, Deli Xiao, Yun Li, Huning Jia*, Hua He*Microwave-assisted synthesis of BSA-modified silver nanoparticles as a selective fluorescent probe for detection and cellular imaging of cadmium (II)Microchim Acta2015182:1255–1261

Hao Dai#, Deli Xiao#, Hua He*, Hui Li, Danhua Yuan, Chan Zhang Synthesis and analytical applications of molecularly imprinted polymers on the surface of carbon nanotubes: a reviewMicrochim Acta, 2015, 182: 893–908

Kai Zhang#, Wenyue Zou, Hongyan Zhao, Pierre Dramou, Chuong Pham-Huy, Jia He, Hua He*Adsorption behavior of a computer-aid designed magnetic molecularly imprinted polymer via response surface methodologyRSC Adv., 2015, 5, 61161–61169

Siqiao Li#, Renfeng Pan, Yamina Ait Mehdi, Deli Xiao*, Hua He*,One-step spontaneous synthesis of fluorescent carbon nanoparticles with thermosensitivity from polyethylene glycolNew J. Chem., 2015, 39, 7033–7039

Jianrong Wu#, Deli Xiao#, Hongyan Zhao, Hua He*, Jun Peng, Cuixia Wang, Chan Zhang, Jia He,A nanocomposite consisting of graphene oxide and Fe3O4 magnetic nanoparticles for the extraction of flavonoids from tea, wine and urine samples. Microchimica Acta, 2015, 182(13-14): 2299-2306.


2014

Deli Xiao#, Danhua Yuan#, Hua He*, Chuong Pham-Huy, Hao Dai, Cuixia Wang, Chan Zhang Mixed hemimicelle solid-phase extraction based on magnetic carbon nanotubes and ionic liquids for the determination of flavonoidsCarbon2014, 72:274-286

Huan He#, Danhua Yuan#, Zhanqi Gao, Deli Xiao*, Hua He*, Hao Dai, Jun Peng, Nan Li, Mixed hemimicelles solid-phase extraction based on ionic liquid- coated Fe3O4/SiO2 nanoparticles for the determination of flavonoids in bio-matrix samples coupled with high performance liquid chromatographyJournal of Chromatography A, 2014132478–85

Huan He#, Deli Xiao#, Jia He,Hui Li*, Hua He*, Hao Dai, Jun Peng,Preparation of core–shell magnetic ion-imprinted polymer by sol-gel process for selective extraction of Cu(II) from herbal medicinesAnalyst20141392459–2466

Xiaobing Li#, Fuguo Shi, Pan Gu , Lingye Liu, Hua He*, Li Ding*, A sensitive LC–MS/MS method for simultaneous determination of amygdalin and paeoniflorin in human plasma and its applicationJournal of Pharmaceutical and Biomedical Analysis, 2014, 92:160–164

Pengli Zuo#, Deli Xiao#, Mengmeng Gao, Jun Peng, Renfeng Pan, Yang Xia, Hua He*, Single-step preparation of fluorescent carbon nanoparticles, and their application as a fluorometric probe for quercetin, Microchim Acta, 2014, 181: 1309-1316

Deli Xiao#, Chan Zhang#, Danhua Yuan, Jia He, Jianrong Wu, Kai Zhang, Rui Lin*, Hua He*, Magnetic solid-phase extraction based on Fe3O4 nanoparticles retrieval of chitosan for the determination of flavonoids in biological samples coupled with high performance liquid chromatographyRSC Adv., 2014, 4, 64843–6485

Mengmeng Gao#, Rui Lin#, Lili Li, Li Jiang, Baofen Ye, Hua He*, Lanlan Qiu, Label-free silver nanoparticles for the naked eye detection of entecavirSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 126 :178–183

Wenyue Zou#, Pierre Dramou#,Lien Ai Pham-Huy, Kai Zhang, Jia He,Chuong Pham-Huy,Deli Xiao*, Hua He*, Simultaneous extraction of anthracyclines from urine using water-compatible magnetic nanoparticles with dummy template coupled with high performance liquid chromatography. Analytical methods, 2014, 6:4421-4429

Lili Li#, Rui Lin#, Hua He*, Meiling Sun*, Li Jiang, Mengmeng Gao, Interaction of amidated single-walled carbon nanotubes with protein by multiple spectroscopic methodsJournal of Luminescence, 2014, 145:125–131

Nan Li#, Yu Gu#, Mengmeng Gao, Zilu Wang, Deli Xiao, Yun Li, Jing Wang* , Hua He*, Label-free silver nanoparticles for visual colorimetric detection of etimicinAnal. Methods, 2014, 6, 7906-7911

肖得力#,李卉,何华*,林锐,左朋礼, 羧基化多壁碳纳米管/Fe3O4磁性复合材料对水中铜( II) 的吸附性能,新型炭材料(英文版)New Carbon Materials2014, 294:15-25


2013

Pierre Dramou#*, Pengli Zuo#, Hua He*, Lien Ai Pham-Huy, Wenyue Zou, Deli Xiao, Chuong Pham-Huy, Theophilus Ndorbora, Anticancer loading and controlled release of novel water-compatible magnetic nanomaterials as drug delivery agents, coupled to a computational modeling approachJ. Mater. Chem. B, 2013, 1, 4099–4109

Deli Xiao#, Pierre Dramou, Nanqian Xiong, Hua He*, Hui Li, Danhua Yuan, Hao Dai, Development of novel molecularly imprinted magnetic solid-phase extraction materials based on magnetic carbon nanotubes and their application for the determination of gatifloxacin in serum samples coupled with high performance liquid chromatography. Journal of Chromatography A 2013, 1274, 44-53.

Pierre Dramou# , Pengli Zuo#, Hua He*, Lien Ai Pham-Huy, Wenyue Zou, Deli Xiao, Chuong Pham-Huy, Development of novel amphiphilic magnetic molecularly imprintedpolymers compatible with biological fluids for solid phase extractionand physicochemical behavior studyJournal of Chromatography A 20131317110-120

Deli Xiao#, Pierre Dramou, Nanqian Xiong, Hua He*, Danhua Yuan, Hao Dai, Hui Li, Xiaomei He, Jun Peng and Nan LiPreparation of molecularly imprinted polymers on the surface of magnetic carbon nanotubes with pseudo template for rapid simultaneous extraction of four fluoroquinolones in egg samples. Analyst 2013, 138, 3287-3296

Pierre Dramou#, Deli Xiao, Hua He*, Tiebing Liu, Wenyue Zou, Loading behavior of gatifloxacin in urine and lake water on a novel magnetic molecularly imprinted polymer used as extraction sorbent with spectrophotometric analysis. Journal of Separation Science, 2013, 36 (5), 898-906.

Hua He#, Lien Ai Pham-Huy, Pierre Dramou,Deli Xiao,Pengli Zuo,Chuong Pham-Huy*, Carbon Nanotubes: Applications in Pharmacy and MedicineBiomed Res Int. 2013;2013:578290. doi: 10.1155/2013/578290. Epub 2013 Sep 30.

Lili Li#, Rui Lin#,Hua He*, Li Jiang, Mengmeng Gao, Interaction of carboxylated single-walled carbon nanotubes with bovine serum albumin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 105: 45-51.

Deli Xiao#Danhua YuanHua He*Jinrong Lu, Microwave-assisted one-step green synthesis of amino- functionalized fluorescent carbon nitride dots from chitosan. Luminescence, 2013, 28, 612-615.

Deli Xiao# Danhua Yuan#, Hua He*, Mengmeng Gao, Microwave assisted one-step green synthesis of carbon nitride dots from ionic liquids and their application as novel fluorescence probe for quercetin determination. Journal of Luminescence 2013, 140, 120-125.

Hui Li#, Deli Xiao, Hua He*, Rui Lin, Pengli Zuo, Adsorption behavior and adsorption mechanism of Cu(II) ions on amino-functionalized magnetic nanoparticlesTrans. Nonferrous Met. Soc. China 2013232657−2665



2012

Deli Xiao#, Pierre Dramou#, Hua He* , Lien Ai Pham-Huy, Hui Li, Yuyang Yao, Chuong Pham-Huy, Magnetic carbon nanotubes: synthesis by a simple solvothermal process and application in magnetic targeted drug delivery systemJ Nanopart Res201214:984-996

Li Jiang#, Tiebing Liu, Hua He*, Lien Ai Pham-Huy, Lili Li, Chuong Pham-Huy, Deli Xiao, Adsorption Behavior of Pazufloxacin Mesilate on Amino-Functionalized Carbon Nanotubes, Journal of Nanoscience and Nanotechnology, 2012, 12:1-9

Xiaomei He#, Rui Lin#, Hua He*, Meiling Sun*, Deli Xiao, Molecularly Imprinted Stationary Phase Prepared by Reverse Micro-emulsion Polymerization for Selective Recognition of Gatifloxacin in Aqueous MediaJ. Chromatogr Sci2012506):499-509

Xiaomei He#, Rui Lin#, Hua He*, Meiling Sun*, Deli Xiao, Chiral Separation of Ketoprofen on a Chirobiotic T Column and Its Chiral Recognition MechanismsChromatographia201275:1355–1363

谷雨#, 何华*, 谭树华, 李悦, 何佳.离子液体双水相技术萃取头孢呋辛酯及其机理探究,分析化学,2012408):1252-1256  

李悦#, 谷雨, 何佳, 何华*, 周祎, ChuongPham-Huy ,光谱法与分子模拟技术研究杨梅素与牛血清白蛋白的相互作用,化学学报,2012702:143-150

李 洁#, 刘铁兵*,肖得力,Dramou Pierre,邹雯月, 何华*,纳米结构分子印迹聚合物及其在药物分析中的应用进展,分析化学,2012408):1461-1468


2011

Zhe Chen#, Dramou Pierre, Hua He*, Shuhua Tan*, Chuong Pham-Huy, Hao Hong, Jilong Huang, Adsorption behavior of epirubicin hydrochloride on carboxylated carbon nanotubes International Journal of Pharmaceutics, 2011, 4051-2):153-161

LiJiang#, TiebingLiu , HuaHe*, Pham-Huy, AiLien, LiliLi, ChuongPham-Huy, DeliXiao, The interaction between ketoprofen and bovine serum albumin by molecular simulation and spectroscopic methods. Spectroscopy, 2011, 26: 337-348.

陈喆#何华*,谭树华,查隽,黄继龙, 三种酸氧化法对多壁碳纳米管的功能化及其含氧官能团含量的比较研究,分析化学, 2011395:718-722

查隽#何华*,刘铁兵,李杉杉,焦庆才, 荧光光谱法研究共存碳纳米管对牛血清白蛋白与加替沙星相互作用的影响,光谱学与光谱分析,2011311:149-153

张慧#何华*,李洁,李卉,姚誉阳, 分子印迹水相分离技术及其在分析化学中的应用,化学进展,2011210:2140-2150

丁荣敏#何华*,李娟, 聚酰胺-胺树状大分子靶向给药系统的研究进展, 药学学报,  2011, 46 (5): 493−501



2010

王志群#,陈石,吕燕妮,倪坤仪,何华*, 米托蒽醌与β-DNA相互作用的分子模拟,化学学报,2010686: 551-556

张怀敬#, 何华*,吕燕妮, 顾艳, Chuong Pham-Huy, PAMAM树状大分子对酮基布洛芬溶解度的影响,高分子学报,2010,7876-883

张怀敬#何华*,李杉杉,芦金荣,Chuong Pham-Huy, 不同代PAMAM 树状大分子与牛血清白蛋白的相互作用研究,化学学报,20106817:1741-1748