HONG, JIN

Release date:2016-05-17  Release:


HONG, JIN

Associate Professor of Inorganic Chemistry

School of Basic Science

Phone: +86-025-86185163

Email: 1020061158@cpu.edu.cn

Research Summary

Bioinorganic Chemistry

The interaction of metal complexes with biomolecules,

  1. the composition, binding sites and the subsequent cleavage activity of metal complexes with peptides and proteins.

  2. the nuclease activity of metal complexes toward plasmid DNA.


Nanotechnology

  1. Construction of FRET based nanoprobes, composed of Au nanoparticles and CdTe/CdSquantum dots, and its application in the medical and biological fields.

  2. Construction of a nanofluorescent switch for early diagnosis andstaging studies of breast cancer.

Education

2006       M.S. and Ph.D., Bioinorganic Chemistry, Nanjing

University

2001       B.S., Inorganic Chemistry, Anhui Normal

University

Academic Experience

2011-     Associate Professor of Inorganic Chemistry, School of Basic Science, China Pharmaceutical University

2013-2014 Visiting Scholar, Department of Chemical Engineering, University of Michigan

2008-2011   Postdoc. Biology, Nanjing University

Publications

  1. Matthew J. McGuffie, Jin Hong (co-first auther), Joong Hwan Bahng, Emmanouil Glynos, Peter F. Green, Nicholas A. Kotov, John G. Younger, J. Scott VanEpps. Zinc Oxide Nanoparticle Suspensions and Layer-By-Layer Coating Inhibit Staphylococcal Growth. Nanomedicine, 2016,12, 33-42.

  2. Yu-Feng, Chen, Jin Hong (co-first auther), Dong-Yan Wu, Ying-Ying Zhou, Mathew D′Ortenzio, Ya Ding, Xing-Hua Xia. In vivo Mapping and Assay of Matrix Metalloproteases for Liver Tumor Diagnosis. RSC Adv., 2016, 6, 8336-8345.

  3. 崔腾,洪瑾,丁娅,张灿. 聚合物修饰的金纳米粒在癌症治疗中的研究进展, 《药学学报》, 2016, 51(2), 281-286.

  4. Sang-Ho Cha, Jin Hong, Matt McGuffie, Bongjun Yeom, J. Scott VanEpps, Nicholas A. Kotov. Shape-Dependent Biomimetic Inhibition of Enzyme by Nanoparticles and their Antibacterial Activity. ACS Nano, 2015, 9(9), 9097-9105.

  5. Ya Ding*, Ying-Ying Zhou, Huan Chen, Dong-Dong Geng, Dong-Yan Wu, Jin Hong, Wen-Bin Shen, Tai-Jun Hang, Can Zhang, The performance of thiol-terminated PEG-paclitaxel-conjugated gold nanoparticles. Biomaterials, 2013, 34(38), 10217-10227.

  6. 洪瑾,马智宇,陈沫,丁娅*. 基于能量转移机制的正、负功能团相互作用研究,《中国科技论文》,2013, 8(3), 199-202.

  7. 洪瑾,格桑德吉,王敏,杭太俊,丁娅*. 柱前衍生化HPLC法分离苏氨酸对映体的研究, 《中国科技论文》,2012, 7(12)913-916.

  8. Jin Hong,Yang Jiao,Weijiang He*, Zijian Guo,Zhen Yu, Junfeng Zhang, Longgen Zhu.“His-oriented peptide hydrolysis promoted by cis-[Pt(en)(H2O)2]2+: a new specific peptide cleavage site”,Inorg. Chem. 2010,49, 8148-8154.

  9. Jin Hong, Jianbin Yan, Yunling Li, Yang Jiao, Weijiang He*, Zijian Guo, Longgen Zhu. “DNA cleavage promoted by trigonal-bipyramidal zinc(II) and copper(II) complexes formed by asymmetric tripodal tetradendate 2-[bis(2-aminoethyl)amino]ethanol”, Inorg. Chimica. Acta 2010,363, 793-798.

  10. Jin. Hong, Y. Jiao, J.F. Zhang, et al., Intermolecular interaction between PdII complex of 2-(bis(2-aminoethyl)amino) ethanol and Met, His or Cys-containing peptides, Chinese J. Inorg. Chem. 2009, 25, 2105-2112.

  11. Jin Hong, Ren Miao, Chunmei Zhao, Jiang Jiang, Huiwei Tang, Zijian Guo, Longgen Zhu. “Mass spectrometry assisted assignments of binding and cleavage sites of copper(II) and platinum(II) complexes towards oxidized insulin B chain”, J. Mass. Spectrom. 2006, 41, 1061-1072.

  12. Jin Hong, Yi Miao, Ren Miao, Gaosheng Yang, Huiwei Tang, Zijian Guo, Longgen Zhu.Binding sites of [Ru(bpy)2(H2O)2](BF4)2 with sulfur and histidine-containing peptides studied by electrospray ionization mass spectrometry and tandem mass spectrometry”, J. Mass. Spectrom. 2005, 40, 91-99.

  13. Jin Hong, Gaosheng Yang, Chunying Duan, Zijian Guo, Longgen Zhu. “Fluorescence quenching of EB-DNA complex by a novel di-bipyridyl ruthenium(II) complex of p-tert-butyltetrathiacalix[4]arene”, Inorg. Chem. Commun. 2005, 11, 988-991.

  14. Jin Hong, Ren Miao, Yizhi Li, Gaosheng Yang, Zijian Guo, Longgen Zhu. “Selective inclusion of fluoboric acid by tetra(p-tert-butyl)-thiacalix[4]arene: Crystal structure and theoretical study”, Chin. J. Chem. 2005, 23, 233-236.

  15. Jin Hong, Chen Yang, Yizhi Li, Gaosheng Yang, Chen Jin, Zijian Guo, Longgen Zhu.Dimeric water embedded within a hydrophobic cavity of tetra-(p-tert-butyl)thiacalix [4]arene”, J. Mol. Struct. 2003, 655, 435-441.