CHEN, GUOHUA

Release date:2016-05-17  Release:

 

CHEN, GUOHUA

Associate Professor of medicinal chemistry

School of pharmacy

Phone: 86-25-83241246

Email: cgh63@163.com

Research Summary

Professor CHEN’s research focuses on the new drugs development. He pays attention to the combination of scientific research and production, and some of drugs he developed have been approved by SFDA. Recent years, his main research interests are the development of antiviral, antineoplastic and cardiovascular drugs. He has taken charge of several  scientific projects, and published more than 50 papers and 20 patents.

Education

1991       Ph.D., Medicinal Chemistry, China Pharmaceutical University

1988       M.S., Medicinal Chemistry, China Pharmaceutical University


1983       B.S.,  chemical pharmaceuticalChina Pharmaceutical University

Academic Experience

1991-      Associate Professor of medicinal chemistry, China Pharmaceutical University

1983-1985  Intern Research ScientistFujian Institute of General Medical Sciences

Awards and Honors

2011       Patent award, Fujian provincial government

2011       First Prize, for Technological Invention AwardFujian provincial government

Publications

  1. Guohua Chen*. Qiang Yin. Jian Yin. Xiangying Gu. Xiao Liu.Qidong You. Yue-Lei Chen*. Bing Xiong*.Jingkang Shen*,Strained Olefin Enables Triflic Anhydride Mediated Direct Dehydrative Glycosylation[J]. Organic & Biomolecular Chemistry,2014, 9781-9785.

  2. Xiao Liu. Qiang Yin. Jian Yin. Guohua Chen. Xin Wang. Qi-Dong You*. Yue-Lei Chen*.Bing Xiong*. Jingkang Shen*.Highly Stereoselective Nucleophilic Addition of Difluoromethyl-2-pyridyl Sulfone to Sugar Lactones and Efficient Synthesis of Fluorinated 2-Ketoses[J]. European Journal of Organic Chemistry, 2014, 6150-6154.

  3. Xiao Liu. Bingbing Zhang. Xiangying Gu. Guohua Chen. Lin Chen. Xin Wang. Bing Xiong. Qi-Dong You*. Yue-Lei Chen*. Jingkang Shen*, 1,2-trans-1-Dihydroxyboryl Benzyl S-Glycoside as Glycosyl Donor[J], Carbohydrate Research, 2014, 398, 45-49.

  4. Xiangying Gu. Lin Chen. Xin Wang. Xiao Liu. Qidong You. Wenwei Xi. Li Gao. Guohua Chen*. Yue-Lei Chen*. Bing Xiong*. Jingkang Shen*, Direct Glycosylation of Bioactive Small Molecules with Glycosyl Iodide and Strained Olefin as Acid Scavenger[J]. The Journal of Organic Chemistry, 2014, 79 (3), 1100-1110.

  5. Guohua Chen*. Xiangying Gu. Lin Chen. Xin Wang. Yue-Lei Chen*. Jingkang Shen*. Wenbin Zeng*, Neoglycopeptide synthesis by Suzuki-Miyaura couplings between unprotected glycosyl aryl boronic acids and iodopeptides[J], Proptein & Peptide Letters, 2014, 21, 1004-1010.

  6. Zhiguo Liu. Pengfei Rong. Xiangying Gu. Lun Yu. Guohua Chen. Yue-Lei Chen*. Shuai Zhang*. Jingkang Shen*. Wenbin Zeng*, A novel strategy for preparing glycopeptide molecular probe using fluorous labeling technology[J], Proptein & Peptide Letters, 2014, 21, 1011-1016.

  7. Guohua Chen. Li Wang. Dihydropyridine calcium antagonist compounds, preparation methods, and medical uses thereof. US. 8,163,907 B2[P].2012.04.24.

  8. Guohua Chen*. Sheng Wang. Feihua Wu. A practical synthesis of sarpogrelate hydrochloride and in vitro platelet aggregation inhibitory activities of its analogues[J]. Chinese Chemical Letters, 2010, 21(3): 287-289.

  9. Xiaochuan Luo . Guohua Chen*. Hui Bin Zhang. Wen Long Huang. A novelsynthetic route for 2-[2-(2,2,2-trifluoroeth oxy) phenoxy]ethanamine[J]. Chinese Chemical Letters,2008191):59-60.