FENG,FANG

Release date:2016-05-17  Release:

FENG,FANG

Professor of Pharmaceutical Analysis

School of Pharmacy

Phone: 86-18118996990

Email: fengfang1@hotmail.com

Research Summary

Professor FENG’s research focuses on Drug Quality Research and Evaluation, using modern instrument analysis technologies, which includes biopharmaceutical analysis, enantioseparation and stereo-selective pharmacokinetics in vivo of chiral drugs, metabolomics for the study of complex systems, such as efficacy material base of traditional Chinese medicines (formula), and so on. She recently published papers entitled "Untargeted metabolomic analysis using LC–TOF/MS and LC–MS/MS for revealing metabolic alterations linked to alcohol-induced hepatic steatosis in rat serum and plasma" and "Metabolomics appro-ach to identify therapeutically potential biomarkers of the Zhi-Zi-Da-Huang decoction effect on the hepatoprotective mechanism", which develop reliable untargeted metabolomic methods based LC-TOF/MS, LC-MS/MS and  NMR to explain the therapeutic mechanism of TCM formula on a comprehensive scale.

Education

1998      Ph.D., Pharmaceutical Analysis, China Pharmaceutical University

1986      M.S.,  Pharmaceutical Analysis, China Pharmaceutical University

1978      B.S., Analytical Chemistry, Anhui University


Academic Experience

1989-   Work in Department of Pharmaceutical Analysis, China Pharmaceutical University; A senior visiting scholar in Department of Pharmacy, Gifu Pharmaceutical University(2000-2001); Academic leaders of Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education). She is Commissioners of Chinese Pharmacopoeia Commission, Chinese Veterinary Drug Standard Committee, CFDA Expert Committee on safety of functional Food and specifications; Evaluation expert of National Science and Technology Award; Appraises expert of SFDA health food, cosmetics, veterinary; Expert of National Database of Science and Technology Experts; Peer reviewer of  university under  the Ministry of Educa-tion;  Appraises expert of new drugs and health food in Jiangsu province; Editorial Board of Journal of Pharmaceutical Analysis and Journal of China Pharmaceutical University.

1982-1986     Assistant of Analytical ChemistryChuzhou University

Awards and Honors

1997       Associate editor of "Organic Spectroscopy", which won the

third prize of State Pharmaceutical Administration Science and Technology Progress Award

2003      Principal member of editorial board of "Fifteen" national

key textbook "Pharmaceutical Analysis"

2006       Young and middle-aged academic leaders of “Qinglan

Project” of Jiangsu province; Primary member of provincial quality course

2007      The first batch of young and middle-aged leaders in science and technology in "333 high-level personnel training project" of  Jiangsu Province;  Head of "Drug Spectroscopy Selected Works", which was named excellent graduate courses in Jiangsu province

2007,2009,2010 Advisor of outstanding graduate theses of Jiangsu Province


2010,2012       Tutor of the second prizes for Shenghe graduate

innovation achievement                 

Publications

1.  Chemical profiling approach to evaluate theinfluence of traditional and simplifieddecoction methods on the holistic quality of Da-Huang-Xiao-Shi decoction using high-performance liquid chromatography coupled with diode-array detection and time-of-flight mass spectrometry. Journal of Separation Science. 2016, 39, 1442-1453.

2.Untargeted metabolomic analysis using LC–TOF/MS and LC–MS/MS

forrevealing metabolic alterations linked to alcohol-induced hepatic steatosis in

ratserum and plasma. RSC Advances, 2016, 6, 28279 – 28288.

3.   Proton-Coupled Organic Cation Antiporter Contributes to the Hepatic Uptake of Matrine. Journal of Pharmaceutical Sciences, 2016, 105: 1301 - 1306.

4.  Metabolomics approach to identify therapeutically potential biomarkers of Zhi-Zi-

Da-Huang Decoction effect on hepatoprotective mechanism.RSC Advances. 2015, 5, 84048 – 84055.

5.  An untargeted metabolomics-driven approach based on LC–TOF/MS and LC

MS/MS for the screening of xenobiotics and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma. Journal of Pharmaceutical and Biomedical Analysis.2015,115:315–322.

6.  Network Pharmacology-Based Antioxidant Effect Study of Zhi-Zi-Da-Huang Decoction for Alcoholic Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2015, Volume 2015, Article ID 492470, 6 pages.

7.  An effective integrated method for comprehensive identification of eighty-five compounds in Zhi-Zi-Da-Huang decoction by HPLC-DAD-ESI-MS (TOF) and HPLC-DAD-ESI-MS/MS (QqQ) without the help of reference standards. Analytical method. 2014, 6:4312-4327.

8.  Optimization of the separation and determination of nitidine and chelerythrine in zanthoxylum nitidum by high-performance liquid chromatography with fluorescence detection. J Chromatogr Sci. 2014 , 52(2):164-168.

9.  Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: restoration of monoamine neurotransmitters in discrete brain regions. Pharm Biol. 2013, 51(2):213-20.

10. Pharmacokinetics of Geniposide in Zhi-Zi-Hou-Pu Decoction and in Different Combinations of its Constituent Herbs. Phytotherapy Research. 2012, 26: 67-72. 

11. A highly sensitive nonenzymatic glucose sensor based on CuO nanowires. Microchim Acta. 2012, 176:411-417.

12. Pyrosequencing on nicked dsDNA generated by nicking endonucleases. Anal Chem. 2010, 82(5):2074-81.

13. Determination of selected elements in aqueous extractions of a traditional Chinese medicine formula by ICP-MS and FAAS: evaluation of formula rationality. Analytical Letters, 2010, 43: 983-992.

14. Pharmaceutical Analysis(editor in chief). Nanjing, China. Publishing House of Southeast University. 2011.

15. Organic Spectroscopy(associate editor). Beijing, China. People's Medical Publishing House. 1995.