HE, LING

Release date:2016-05-17  Release:

  

HE, LING

Professor of Pharmacology

School of Pharmacy

Phone: 86-25-13851612452

Email: hexyz@163.com

Research Summary

At present, the prevalence of Alzheimer’s disease (AD) is increasingly high in the world, which seriously affects the quality of life of the elderly. However, there’s no cure for the disease. Based on the above reasons, Professor HE’s research focuses on the mechanism and therapeutic targets of AD and related drug development.In recent five years, she have gained the support of seven national and three provincial fund, including the National Natural Science Fund, Jiangsu Natural Science Fund, China Postdoctoral Science fund, Agricultural Science and Technology Achievement Transformation Fund, etc. From 2012 to 2015, she as the general superintendent of the lead unit took charge of the National 12th Five-year Plan “Major Scientific and Technological Special Project for Significant New Drugs Creation” project of Novel G protein-coupled receptor targeted drug screening system and key technology researchNO.2012ZX09504001-001and the Guangdong provincial major scientific project “Preclinical study on the treatment of Alzheimer’s disease with original new drug polyprenols extracted from needles of Pinus Massoniana”. Her group applied for 9 patents on related research in which 2 patents authorized, and have published over 40 research articles in domestic and foreign journals among which more than 30 were included in the SCI.Her research findings won a Servier Young Investigator Prize in Pharmacology, the first prize of Jiangsu Science and Technology Progress Award and the Program for New Century Excellent Talents in University.

  

  

Education

2002Ph.D., Pharmacology, China Pharmaceutical University

1995M.S., Pharmacology, China Pharmaceutical University

1992B.S.,Pharmacochemistry, China Pharmaceutical University

Academic Experience

2009-Professor of Pharmacology, School of Pharmacy

2004-2009 Associate professor of Pharmacology, School of Pharmacy

Awards and Honors

2010Program for New Century Excellent Talents in University, Ministry of Education

Publications

(1) Ling ShenMing YanLing He* D5 receptor agonist 027075 promotes

cognitive function recovery and neurogenesis in a Aβ1-42-induced mouse modelNeuropharmacology201610572-83

(2) Muhammad Zahid KhanLing He*The role of polyunsaturated fatty

acids and GPR40 receptor in brainNeuropharmacology2015Available online2015/5/22):1-12

(3)Cong Wang Ming YanGuangyao ZhenXiaoyang Liu,Ling He*Effects

of polyprenols from pine needles of Pinus massonianaon ameliorating cognitive impairment in a D-galactose-inducedmouse modelAge2014364):9676-9687

(4)Yue WANGMing YANGuang-yao ZHENG, Huan YANG, Ling HE*A

cell-based, high-throughput homogeneous timeresolvedfluorescence assay for the

screening ofpotential κ-opioid receptor agonistsActa Pharmacologica Sinica2014357):957-966

(5)Ji Bian-Sheng Cen JuanLiu LuHe Ling*In vitro and in vivo study of dolichyl phosphate on the efflux activity of P-glycoprotein at the blood-brain barrierInternational Journal of Developmental Neuroscience2013318):828-835

(6) Ji Bian-Sheng, Cen Juan, He Ling*, Liu Meng, Liu Yan-QingLiu Lu , Modulation of P-glycoprotein in rat brain microvessel endothelial cells under oxygen glucose deprivationJournal of Pharmacy and Pharmacology20136510):1508-1517

(7) Taotao Zhou, Ling He*, Ming Yan, Luyong Zhang, Jianguo He, Xiaoping Rao

Tyrosine kinase inhibitory activity of dehydroabietylamine derivativestested by homogeneous time-resolved fluorescencebased high throughput screening modelChinese Journal of Natural Medicines2013115):0506-0513

(8) Huan Yang, Ming Yan, Jianguo He, Tao Yu, Ling He*, High Throughput Screening and Structure-Activity Relationship Study of Potential α2A-Adrenoceptor Agonists by LANCETM cAMP AssayCombinatorial Chemistry &High Throughput Screening2013167):522-530

(9)Abdelaziz Ghanemi, Ming Yan, Ling He*, New factors influencing Gprotein coupled receptors’ system functionsAlexandria Journal of Medicine2012491-5

(10) Wu QibiaoLi HaitaoWu YeShen WeixingZeng LiCheng HaiboHe Ling* , Protective effects of muscone on ischemia-reperfusion injury in cardiac myocytesJOURNAL OF ETHNOPHARMACOLOGY20111381):34-39

(11) Ji Bian-Sheng, Ren Yan-Li, He Ling*, The Effect of Combined CJZ3, a Lomerizine Derivative, With Verapamil on P-glycoprotein Efflux Function In VitroDRUG DEVELOPMENT RESEARCH2011724):305-309