SUN, HAIYING

Release date:2016-05-17  Release:



 

SUN, HAIYING

Professor of Medicinal Chemistry

Department of Medicinal Chemistry

School of Pharmacy

Phone: 13951619649

Email: haiyings1969@163.com

Research Summary

Professor Sun’s research interest is in the design, synthesis and biological evaluation of novel small molecular agents targeting crucial proteins in human diseases. He played a leading role in a project to identify small molecular inhibitors of IAPs. Two clinical candidates have been identified in this project and are currently in Phase I/II studies. He has been awarded 9 US Patents and published 30+ papers on top journals in the fields of Medicinal Chemistry and Organic Chemistry.  

Education

2000       Ph.D., Organic Chemistry, Shanghai Institute of Organic Chemistry

1997       M.S., Organic Chemistry, Lanzhou University

1991       B.S., Applied Chemistry, Lanzhou University

Academic Experience

2014-      Professor of Medicinal Chemistry, China Pharmaceutical University

2008-2014  Research Assistant Professor, University of Michigan

2003-2008  Research Investigator, University of Michigan

2002-2003  Postdoctoral Research Fellow, University of Michigan

2000-2002  Postdoctoral Research Fellow, Georgetown University

Awards and Honors

2013     Specially Appointed Professor of Jiangsu Province

Representative Publications

  1. Haiying Sun, Jianfeng Lu, Liu Liu, Han Yi, Su Qiu, Chao-Yie Yang and Shaomeng Wang; Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells; ACS Chem. Bio.; 2014, 9(4); 994-1002.

  2. Rong Sheng, Haiying Sun, Liu Liu, Jianfeng Lu, Donna McEachern, Guanfeng Wang, Jianfeng Wen, Ming Guo,  Dajun Yang and Shaomeng Wang. A Potent Bivalent Smac Mimetic (SM-1200) Achieving Rapid, Complete, and Durable Tumor Regression in Mice;  J. Med. Chem., 2013, 56(10), 3969-3979.

  3. Yuefeng Peng, Haiying Sun, Jianfeng Lu, Liu Liu, Han Yi, Su Qiu, Chao-Yie Yang and Shaomeng Wang*; Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents; J. Med. Chem.;2012, 55(1), 106-114.

  4. Haiying Sun, Liu Liu, Jianfeng Lu, Longchuan Bai, Xiaoqin Li, Zaneta Nikolovska-Coleska,Chao-Yie Yang, Su Qiu, Han Yi, Duxin Sun and Shaomeng Wang*; PotentbivalentSmacmimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity; J. Med. Chem.; 2011; 54(9); 3306-3318.

  5. Qian Cai, Haiying Sun (co-first author), Yuefeng Peng, Jianfeng Lu, Zaneta Nikolovska-Coleska, Donna McEachern, Liu Liu, Su Qiu, Chao-Yie Yang, Rebecca Miller, Han Yi, Tao Zhang, Duxin Sun, Sanmao Kang, Ming Guo, Dajun Yang, Shaomeng Wang. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment; J. Med. Chem.; 2011; 54(8);2714-2726.

  6. Haiying Sun, Jianfeng Lu, Liu Liu, Han Yi, Su Qiu, Chao-Yie Yang, Jeffrey R. Deschamps and Shaomeng Wang. Nonpeptidic and potentsmall-moleculeinhibitors of cIAP-1/2 and XIAPproteins; J. Med. Chem., 2010, 53(17), 6361-6367.

  7. Haiying Sun, Liu Liu, Jianfeng Lu, Su Qiu, Chao-Yie Yang, Han Yi, Shaomeng Wang*; Cyclopeptide Smac mimetics as antagonists of IAP proteins; Bioorg. Med. Chem. Lett. 2010, 20 (10); 3043-3046.

  8. Chao-Yie Yang, Haiying Sun, Jianyong Chen, Zaneta Nikolovska-Coleska, Shaomeng Wang; Importance of Ligand Reorganization Free Energy in Protein-Ligand Binding-Affinity Prediction; Journal of the American Chemical Society; 2009, 131(38), 13709-13721.

  9. Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Dongguang Qin, Jianfeng Lu, Su Qiu, Longchuan Bai, Yuefeng Peng, Qian Cai, and Shaomeng Wang. Design of Small-Molecule Peptidic and Non-Peptidic Smac Mimetics. Accounts of Chemiscal Research (article); 2008, 41(10), 1264-1277.

  10. Haiying Sun, Jeanne A. Stuckey, Zaneta Nikolovska-Coleska, Dongguang Qin, Jennifer L. Meagher, Su Qiu, Jianfeng Lu, Chao-Yie Yang, Naoyuki G. Saito and Shaomeng Wang. Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP). J. Med. Chem.; (Article); 2008, 51 (22), 7169-7180.

  11. Jianfeng Lu, Longchuan Bai, Haiying Sun, Zaneta Nikolovska-Coleska, Donna McEachern, Su Qiu, Rebecca S. Miller, Han Yi, Sanjeev Shangary, Yi Sun, Jennifer L. Meagher, Jeanne A. Stuckey and Shaomeng Wang. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.Cancer Research; 2008, 68 (22), 9384-9393.

  12. Yuefeng Peng, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-YieYang, Su Qiu, Jianfeng Lu, Qian Cai, Han Yi and Shaomeng Wang. Design, Synthesis and Evaluation of Potent and Orally Bioavailable Diazabicyclic Smac Mimetics. J. Med. Chem.; 2008, 51 (24), 8151-8162.

  13. Haiying Sun, Zaneta Nikolovska-Coleska, Jianfeng Lu, Jennifer L. Meagher, Chao-Yie Yang, Su Qiu, Krzysztof Krajewski, Peter P. Roller, Jeanne Stuckey, and Shaomeng Wang. Design, Synthesis and Characterization of A Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Targets both the BIR2 and BIR3 Domains in XIAP. J. Am. Chem. Soc.; (article) 2007, 15279-15294.

  14. Haiying Sun, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu, Chao-Yie Yang, Wei Gao, Jennifer Meagher, Jeanne Stuckey and Shaomeng Wang. Design, Synthesis, and Evaluation of a Potent, Cell-Permeable, Conformationally Constrained Second Mitochondria Derived Activator of Caspase (Smac) Mimetic, J. Med. Chem.;(Brief Article); 2006; 49(26); 7916-7920.

  15. Haiying Sun, Zaneta Nikolobska-Coleska, Chao-Yie Yang, Liang Xu, York Tomita, Peter Roller and Shaomeng Wang, Design, Synthesis and Evaluation of Highly Potent Conformationally Constrained Smac Mimetics, Journal of the American Chemical Society (communication), 2004, 126 (51), 16686-16687.

  16. Haiying Sun; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Liang Xu; York Tomita; Peter P Roller; Shaomeng Wang   Structure-Based Design, Synthesis, and Evaluation of Conformationally Constrained Mimetics of the Second Mitochondria-Derived Activator of Caspase That Target theX-Linked Inhibitor of Apoptosis Protein/Caspase-9 Interaction Site. J. Med.Chem. 2004, 47 (17), 4147-4150.

  17. Alan P. Kozikowski; Haiying Sun; John Brognard; Phillip A. Dennis  Novel PI Analogues Selectively Block Activation of the Pro-survival Serine/Threonine Kinase Akt. J. Am. Chem. Soc. (communication). 2003, 125 (5), 1144-1145.

  18. Dawei Ma and Haiying Sun. A Simple and Stereospecific Route to 2,6-Disubstituted 4-Hydroxypiperidines. Synthesis of Dendrobate Alkaloid (+)-241D and Formal Synthesis of (-)-Indolizidine 167B. Organic Letters. 2000, 2 (16), 2503-2505.

  19. Dawei Ma and Haiying Sun. General Route to 2,4,5-Trisubstituted Piperidines from Enantiopure -Amino Esters. Total Synthesis of Pseudodistomin B Triacetate and Pseudodistomin F. Journal of Organic Chemistry. 2000, 65 (19), 6009-6016.

Awarded Patents


  1. Shaomeng Wang and Haiying Sun. Bivalent diazo bicyclic Smac mimetics and the use thereof.  U.S Pat. Appl. Pub. (2011), 90pp. WO/2011/05006; PCT/US2010/053384.

  2. Shaomeng Wang, Haiying Sun, Dongguang Qin, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu, Yuefeng Peng and Qian Cai.  Preparation of bivalent conformationally constrained Smac peptide mimetics as inhibitors of IAP proteins and inducers of apoptosis. U.S Pat. Appl. Publ. (2009), 137pp, Cont.-in-part of U.S. Ser. No. 800,220.

  3. Shaomeng Wang, Yuefeng Peng, Haiying Sun, Qian Cai, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu. Preparation of diazo bicyclic conformationally constrained Smac peptide mimetics as inhibitors of IAP proteins and inducers of apoptosis. PCT Int. Appl. (2008), 197pp. CODEN; PIXXD2 WO 2008128171 A2 20081023 Can 149;471831 An 2008:1282410 CAPLUS

  4. Shaomeng Wang, Haiying Sun, Dongguang Qin, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu, Yuefeng Peng and Qian Cai. Preparation of bivalent conformationally constrained Smac peptide mimetics as inhibitors of IAP proteins and inducers of apoptosis. PCT Int. Appl.  (2007), 137pp. CODEN: PIXXD2 WO 2007130626  A2  20071115  CAN 147:542134  AN 2007:1302836.

  5. Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu, Naoyuki Saito and Jianyong Chen. Preparation of conformationally-constrained Smac peptidomimetics for use in inducing apoptosis. PCT Int. Appl. (2006), 127 pp. CODEN: PIXXD2  WO  2006010118  A2  20060126  AN 2006:79326 CAPLUS

  6. Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu. Conformationally constrained Smac mimetics and use in inducing apoptosis.  PCT Int. Appl.  (2005), 125 pp. CODEN: PIXXD2  WO 2005069894  A2  20050804  CAN 143:166630  AN 2005:696610 CAPLUS

  7. Shaomeng Wang, Haiying  Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang XuSmac peptidomimetics and use in inducing apoptosis.    PCT Int. Appl.  (2005), 110 pp.  CODEN: PIXXD2  WO  2005069888  A2  20050804  CAN 143:166629  AN 2005:696606 CAPLUS

  8. Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu, Dajun Yang, Zengjian Hu and Guoping Wang. Embelin and other small molecule antagonists of XIAP family proteins, and therapeutic use thereof.  PCT Int. Appl. (2005), 130 pp. CODEN: PIXXD2  WO  2005092326  A1  20051006  CAN 143:360077  AN 2005:1075624 CAPLUS

  9. Alan P. Kozikowski; Phillip A. Dennis; Haiying Sun; John Brognard.  Preparation of cyclitols as serine/threonine kinase Akt inhibitors. PCT Int. Appl.  (2004), 41 pp. WO 2004022569 A1 20040318