XIANG, HUA
Professor/Associate Professor of Medicinal Chemistry
School of Pharmacy
Phone: 86-25-83271096
Email: xianghua@cpu.edu.cn
Research Summary
Professor XIANG’s research mainly focuses on the anticancer drug discovery targeting steroidal hormone receptors or enzymes. She is also engaged in designing and synthesizing innovative agents for senile diseases (menopausal osteoporosis, benign prostatic hyperplasia, hyperlipidaemia, Alzheimer's disease,etc.). Besides, she is interested in the synthesis of clinical available steroidal drugs by using new steroidal sapogenins from naturally occurring plants as starting material, in parallel with studies on utilizing regio- and stereo-specifically methodologies.
Education
2003 Ph.D., Medicinal Chemistry, China Pharmaceutical University
1988 M.S., Analytical Chemistry,Sichuan University
1985 B.S., Organic Chemistry,Sichuan University
Academic Experience
2009- Professor of Medicinal Chemistry, China Pharmaceutical University
2014-2015 Visiting Scholar, Massachusetts Institute of Technology, USA
2004-2009 Associate Professor of Medicinal Chemistry, China Pharmaceutical University
2002-2003 Visiting Scholar, University of Tuebingen, Germany
1996-2000 Senior Scientist of Medicinal Chemistry, Hunan Zhenqin Pharmaceutical Group Corporation
1988-1996 Associate Professor of Medicinal Chemistry, Hunan Institute of Traditional Chinese Medicine and Materia Medica
Publications
Minhang Xin*, Xinge Zhao, Wei Huang, Qiu Jin, Gang Wu, Yazhou Wang, Feng Tang, Hua Xiang*. Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton’s tyrosine kinase (BTK) inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(19): 6250-6257
Xinge Zhao, Minhang Xin, Yazhou Wang, Wei Huang, Qiu Jin, Feng Tang, Gang Wu, Yong Zhao, Hua Xiang*. Discovery of thieno[3,2-c]pyridin-4-amines as novel Bruton’s tyrosine kinase (BTK) inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(17): 6059-6068
Wenbin Wang, Yi He, Pei Xu, Qidong You, Hong Xiao, Hua Xiang*. Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities. Bioorganic & Medicinal Chemistry, 2015, 23 (15): 4428-4433
Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*.Pyrrolo[2,3-b]pyridine derivatives as potent Bruton’s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(15): 4344-4353
Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*. Discovery of novel Bruton’s tyrosine kinase (BTK) inhibitors bearing a pyrrolo [2,3-d]pyrimidine scaffold. Bioorganic & Medicinal Chemistry, 2015, 23(4): 891-901.
Xinge Zhao, Minhang Xin, Wei Huang, Yanliang Ren, Qiu Jin, Feng Tang, Hailong Jiang, Yazhou Wang, Jie Yang, Shifu Mo, Hua Xiang*. Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton’s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(2): 348-364.
Tang ZC, Niu SX, Liu F, Lao KJ, Miao JS, Ji JZ, Wang X, Yan M, Zhang LY, You QD, Xiao H, Xiang H*. Synthesis and biological evaluation of 2, 3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ERα and VEGFR-2. Bioorg Med Chem Lett. 2014, 24(9): 2129-33
Wang L, Zeng Y, Wang T, Liu H, Xiao H, Xiang H*.Evaluating the potential bioactivity of a novel compound ER1626. PLoS One. 2014, 9(1): 1-9
Minhang Xin, Ying Gao, Hua Xiang*, Dong Chen, Yi He, Qidong You. A general and facile synthesis of novel polysubstituted quinazolin-4(3H)-ones. Journal of Heterocyclic Chemistry, 2013, 50(1): 169-174
Chen D, Yang K, Xiang H*, Jiang S. New ligands for copper-catalyzed C–N coupling reactions with aryl halides. Tetrahedron Lett, 2012; 53:7121-7124