XIANG, HUA

Release date：2016-05-17  Release：


XIANG, HUA

Professor/Associate Professor of Medicinal Chemistry

School of Pharmacy

Phone: 86-25-83271096

Email: xianghua@cpu.edu.cn

Research Summary

Professor XIANG’s research mainly focuses on the anticancer drug discovery targeting steroidal hormone receptors or enzymes. She is also engaged in designing and synthesizing innovative agents for senile diseases (menopausal osteoporosis, benign prostatic hyperplasia, hyperlipidaemia, Alzheimer's disease,etc.). Besides, she is interested in the synthesis of clinical available steroidal drugs by using new steroidal sapogenins from naturally occurring plants as starting material, in parallel with studies on utilizing regio- and stereo-specifically methodologies.

Education

2003      Ph.D., Medicinal Chemistry, China Pharmaceutical University

1988       M.S., Analytical Chemistry，Sichuan University

1985       B.S., Organic Chemistry，Sichuan University

Academic Experience

2009-      Professor of Medicinal Chemistry, China Pharmaceutical University

2014-2015 Visiting Scholar, Massachusetts Institute of Technology, USA

2004-2009 Associate Professor of Medicinal Chemistry, China Pharmaceutical University

2002-2003 Visiting Scholar, University of Tuebingen, Germany

1996-2000 Senior Scientist of Medicinal Chemistry, Hunan Zhenqin Pharmaceutical Group Corporation

1988-1996 Associate Professor of Medicinal Chemistry, Hunan Institute of Traditional Chinese Medicine and Materia Medica

Publications

  1. Minhang Xin*, Xinge Zhao, Wei Huang, Qiu Jin, Gang Wu, Yazhou Wang, Feng Tang, Hua Xiang*. Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton’s tyrosine kinase (BTK) inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(19): 6250-6257

  2. Xinge Zhao, Minhang Xin, Yazhou Wang, Wei Huang, Qiu Jin, Feng Tang, Gang Wu, Yong Zhao, Hua Xiang*. Discovery of thieno[3,2-c]pyridin-4-amines as novel Bruton’s tyrosine kinase (BTK) inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(17): 6059-6068

  3. Wenbin Wang, Yi He, Pei Xu, Qidong You, Hong Xiao, Hua Xiang*. Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities. Bioorganic & Medicinal Chemistry, 2015, 23 (15): 4428-4433

  4. Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*.Pyrrolo[2,3-b]pyridine derivatives as potent Bruton’s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(15): 4344-4353

  5. Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*. Discovery of novel Bruton’s tyrosine kinase (BTK) inhibitors bearing a pyrrolo [2,3-d]pyrimidine scaffold. Bioorganic & Medicinal Chemistry, 2015, 23(4): 891-901.

  6. Xinge Zhao, Minhang Xin, Wei Huang, Yanliang Ren, Qiu Jin, Feng Tang, Hailong Jiang, Yazhou Wang, Jie Yang, Shifu Mo, Hua Xiang*. Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton’s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(2): 348-364.

  7. Tang ZC, Niu SX, Liu F, Lao KJ, Miao JS, Ji JZ, Wang X, Yan M, Zhang LY, You QD, Xiao H, Xiang H*. Synthesis and biological evaluation of 2, 3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ERα and VEGFR-2. Bioorg Med Chem Lett. 2014, 24(9): 2129-33

  8. Wang L, Zeng Y, Wang T, Liu H, Xiao H, Xiang H*.Evaluating the potential bioactivity of a novel compound ER1626. PLoS One. 2014, 9(1): 1-9

  9. Minhang Xin, Ying Gao, Hua Xiang*, Dong Chen, Yi He, Qidong You. A general and facile synthesis of novel polysubstituted quinazolin-4(3H)-ones. Journal of Heterocyclic Chemistry, 2013, 50(1): 169-174

  10. Chen D, Yang K, Xiang H*, Jiang S. New ligands for copper-catalyzed C–N coupling reactions with aryl halides. Tetrahedron Lett, 2012; 53:7121-7124