YAO, JING

Release date:2016-05-17  Release:


YAO, JING

Professor of Pharmaceutics

School of Pharmacy

Phone: 86-25-83271299

Email: yaojing@cpu.edu.cn

Research Summary

Professor Yao’s research is being focused on the development of polysaccharides-based nanoparticulate drug delivery system for the delivery of genomic and chemical drugs to improve the drug tumor targeting distribution and cancer therapy efficacy, and reduce the side-effects of drugs. In recent years, her focus has been the design and evaluation of amphiphilic polymer-drug conjugates. Such  polymer-drug conjugatescould self-assemble into the nanoparticles in the aqueous medium and encapsulate the insoluble drugs, which would facilitate the co-delivery of two or three antitumor drugs for combination therapy.Moreover, she also focused onthe study of calcium-based nanoparticles for drug delivery to facilitate the transmembrane transport of drugs and improve their therapeutic effect.


Education

2005   Ph.D., Pharmaceutics, China Pharmaceutical University

2000   B.S.,  Pharmaceutics, China Pharmaceutical University


Academic Experience

2015 to present: Professor of Pharmaceutics, ChinaPharmaceutical University

2012-2013:  Visiting Scholar, The University of North Carolina at Chapel Hill

2009-2015: Associate Professor of Pharmaceutics, ChinaPharmaceutical University

2005-2009: Lecturer of Pharmaceutics, ChinaPharmaceutical University


Awards and Honors

2015  12th of Six Peak Talents of JiangsuProvince, Personnel Department of Jiangsu Province

2013  Cultivation Object of 333 high-level personnel training project of Jiangsu province, Science and Technology Department of Jiangsu Province

2012 Outstanding young teachers of Qing Lan Project, Education Department of Jiangsu Province

2011  YouthPharmaceutics Award of Chinese Pharmaceutical Association, Chinese Pharmaceutical Association

2007  Third Prize for the Science and Technology Progress Award of Chinese Pharmaceutical Association,Chinese Pharmaceutical Association


Publications

  1. Yuanke Li, Yuanyuan Wu, Leaf Huang, Lei Miao, Jianping Zhou, Andrew Benson Satterlee, Jing Yao*. Sigma receptor-mediated targeted delivery of anti-angiogenic multifunctional nanodrugs for combination tumor therapy. J Control Release,2016, 228:107-119. (IF: 7.705)

  2. Jing YaoYuan ZhangSrinivasRamishettiYuhua WangLeaf Huang, Turning an antiviral agent into an anticancer drug: Nanoparticles delivery of ancyclovir monophosphate, J Control Release, 2013, 170(3): 414-420. (IF: 7.705)

  3. Hui Xiong, Shi Du, Jiang Ni, Jianping Zhou, Jing Yao*. Mitochondria and Nuclei Dual-targeted Heterogeneous Hydroxyapatite Nanoparticles for Enhancing Therapeutic Efficacy of Doxorubicin. Biomaterials,2016, 94:70-83.(IF: 8.557)

  4. Xiaoying WangYihang ChenFatima ZohraDahmaniLifang YinJianping ZhouJing Yao*, Amphiphiliccarboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel, Biomaterials, 2014, 35(26): 7654-7665. (IF: 8.557)

  5. Lin Hou#Jing Yao(#equal contribution)Jianping ZhouQiang Zhang, Pharmacokinetics of a paclitaxel-loaded low molecular weight heparin-all-trans-retinoid acid conjugate ternary nanoparticulate drug delivery system, Biomaterials, 2012, 33 (21): 5431-5440. (IF: 8.557)

  6. Jing Yao*, Ying Fan, Ronghui Du, Jianping Zhou, Yun Lu, Wei Wang, Jin Ren and Xiaojing Sun Amphoteric hyaluronic acid derivative for targeting gene delivery. Biomaterials.2010,31(35):9357-9365. (IF: 8.557)

  7. Fatima Zohra Dahmani, Yan Xiao, Juan Zhang, Yao Yu, Jianping Zhou, Jing Yao*. Multifunctional Polymeric Nanosystems for Tumor Cells and Neovasculature Double-Targeted Drug Delivery and Combinatorial Tumor Therapy. Adv. Healthcare Mater. 2016, 10.1002/adhm.201600169   (IF: 5.797)

  8. Jing Yao*Li ZhangJianping ZhouHongpan LiuQiang Zhang, Efficient Simultaneous Tumor Targeting Delivery of All-Trans Retinoid Acid and Paclitaxel Based on Hyaluronic Acid-Based Multifunctional Nanocarrier, Mol Pharm, 2013, 10(3): 1080−1091. (IF: 4.384)

  9. Jing Yao*Yuanke LiXiaojing Sun,Fatima ZohraDahmaniHongpan LiuJianping Zhou, Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid, Int J Nanomed, 2014, 9: 3313–3324. (IF: 4.383)

  10. Yijun WuJing Yao*Jianping ZhouFatima ZohraDahmani, Enhanced and sustained topical ocular delivery of cyclosporine in thermosensitive hyaluronic acid-based in situ forming microgels, Int J Nanomed, 2013, 8: 3587–3601. (IF: 4.383)

  11. Lin HouYing FanJing Yao*Jianping ZhouCaocao LiZhengjie FangQiang Zhang, Low molecular weight heparin-all-trans-retinoid acid conjugate as a drug carrier for combination cancer chemotherapy of paclitaxel and all-trans-retinoid acid, CarbohydPolym, 2011, 86(3): 1157-1166. (IF: 4.074)

  12. ChenfengXu, Yu Ding, Jiang Ni, Lifang Yin, Jianping Zhou, Jing Yao*.Tumor-targeted docetaxel-loaded hyaluronic acid-quercetin polymeric micelles with p-gp inhibitory property for hepatic cancer therapy.RSC Adv,2016, 6: 27542 - 27556. (IF: 3.84)

  13. Ting Zhang, HuiXiong, Fatima ZohraDahmani, Li Sun, Yuanke Li, Li Yao, Jianping Zhou, Jing Yao*. Combination chemotherapy of doxorubicin, all-trans retinoic acid and low molecular weight heparin based on self-assembled multi-functional polymeric nanoparticles. Nanotechnology 2015, 26:145101. (IF: 3.821)

  14. Jin Ren, Zhengjie Fang, Li Yao, Fatima ZohraDahmani, Lifang Yin, Jianping Zhou, Jing Yao *. A micelle-like structure of poloxamer–methotrexate conjugates as nanocarrier for methotrexate delivery.Int J Pharm2015, 20: 487(1-2):177-86. (IF: 3.650)

  15. Wei He, Zhu Jin, Yaqi Lv, Hui Cao , Jing Yao , Jianping Zhou , LifangYin , Shell-crosslinked hybrid nanoparticles for direct cytosolic delivery for tumor therapy, Int J Pharm, 2015, 478(2):762-72. (IF: 3.650)

  16. Li Zhang#, Jing Yao(#equal contribution)Jianping ZhouTao WangQiang Zhang, Glycyrrhetinic acid-graft-hyaluronic acid conjugate as a carrier for synergistic targeted delivery of antitumor drugs, Int J Pharm, 2013, 441(1-2): 654-664. (IF: 3.650)

  17. Ying Fan#Jing Yao(#equal contribution)Ronghui DuLin HouJianping ZhouYun LuQinggangMengQiang Zhang, Ternary Complexes with Core-shell Bilayer for Double Level Targeted Gene Delivery: In Vitro and In Vivo Evaluation, Pharm Res, 2013, 30(5): 1215–1227.(IF: 3.420)

  18. Fatima Zohra DahmaniHui YangJianping ZhouJing Yao*Ting ZhangQiang Zhang, Enhanced oral bioavailability of paclitaxel in Pluronic/LHR mixed polymeric micelles: Preparation, in vitro and in vivo evaluation, Eur J Pharm Sci, 2012, 47(1): 179-189. (IF: 3.350)