HUO, MEIRONG

Release date:2016-05-17  Release:

HUO, MEIRONG

Associate Professor of Pharmaceutics

School of Pharmacy

Phone: 86-25-83271102

Email: huomeirongcpu@163.com

Research Summary

Professor Huo’s research focuses on the development of novel drug/siRNA delivery systems such as micelles or prodrugs with improved bioefficiency. Our work have successfully synthesis of various derivatives of naturally occurring materials such as chitosan, albumin and hyaluronic acidwith mutifunctions such as tumor active targeting, redox-sensitive or pH-sensitive properties.The nanoparticles or micelles based on the synthesized materials exhibited excellent loading capacities for drugs or siRNA, and possessed superior tumor-targeting ability and antitumor activityboth cell and animal models.

Education

2001-2006       Ph.D., Pharmaceutics, China Pharmaceutical University

1997-2001       B.S., Pharmaceutics, China Pharmaceutical University

Academic Experience

2010-      Associate Professor of Pharmaceutics, China Pharmaceutical University

2006-2009  Senior Research Scientist of Pharmaceutics, China Pharmaceutical University

Awards and Honors

2013    Second prize of excellent multimedia of China Pharmaceutical Univerisity, China

2012Cultivate Middle-aged and Young Science Leaders of Colleges and Universities of Jiangsu Province, China

2012Outstanding Young Pharmaceutical Scientists Award, Chinese Pharmaceutical Association, China

2012Second Prize of Excellent Paper in China Pharmaceutical Conference, China

2009Second Prize of Teaching Achievement in China Pharmaceutical University

2009Third Prize of Teaching Competition in China Pharmaceutical University

2008Second Prize of Excellent Paper in East China Pharmaceutical Conference, China

2007Third Prize of the Science and Technology Award, Chinese Pharmaceutical Association 

2007First Prize of Teaching Competition for Young Teachers of China Pharmaceutical University.

Publications

1. Zhang XY, Yang CY, Zhou JP*, Huo MR*, Somatostatin receptor-mediated tumor-targeting nanocarriers based on octreotide-PEG conjugated nano-graphene oxide for combined chemo- and photothermal therapy, Small, 2016,  ( IF 8.368)

2. Huo MR, LiuY, WangL, Yin TJ, QinC, XiaoYY, YinLF, LiuJY*, Zhou JP*, Redox-sensitive micelles based on O, N-hydroxyethyl chitosan-octylamine conjugates for triggered intracellular delivery of paclitaxel, Mol Pharm. 2016 ( IF4.384)

3. Yin TJ, Cai H, Cui B, Wang L, Yin LF, Zhou JP* and Huo MR*, Biological evaluation of PEG modified nanosuspensions based on human serum albumin for tumor targeted delivery of paclitaxel, Eur J Pharm Sci, 2016, 83(15), 79–87  (IF3.35)

4. Yin TJ, Wang L, Yin LF, Zhou JP*, Huo MR*. Co-delivery of hydrophobic paclitaxel and hydrophilic AURKA specific siRNA by redox-sensitive micelles for effective treatment of breast cancer. Biomaterials. 2015;61:10-25.  (IF 8.557)

5. Yin TJ, Wang J, Yin LF, Shen LJ, Zhou JP*, Huo MR*.Redox-sensitive hyaluronic acid-paclitaxel conjugate micelles with high physical drug loading for efficient tumor therapy. Polym Chem. 2015,6, 8047-8059 ( IF 5.52)

6. Yin TJ, Wu Q, Wang L, Yin LF, Zhou JP, Huo MR*.Well-defined Redox-sensitive Polyethene glycol-Paclitaxel Prodrug Conjugate for Tumor Specific Delivery of Paclitaxel Using Octreotide for Tumor-targeting.Mol Pharm. 2015 3;12(8):3020-31 (IF4.384)

7. Yin TJ, Dong LH, Cui B, Wang L, Yin LF,  Zhou JP* , Huo MR*, A toxic organic solvent-free technology for the preparation of PEGylated paclitaxel nanosuspension based on human serum albumin for effective cancer therapy, Int J Nanomed, 2015:10 ,7397-7412 (IF 4.383)

8. Li JYin TJZhou JPHuo MR*Biological evaluation of redox-sensitive micelles based on hyaluronic acid-deoxycholic acid conjugates for tumor-specific delivery of paclitaxelInt J Pharm. 2015, 483(1-2):38-48  (IF=3.65)

9. Huo MRZhu QNWu QYin TJWang LeiYin LFZhou JPSomatostatin receptor-mediated specific delivery of paclitaxel prodrugs for efficient cancer therapyJ Pharm Sci2015;104(6):2018-28 (IF=2.59)

10. Zhao Y, Huo MR, Xu ZH, Wang YH, Huang L. Nanoparticle delivery of CDDO-Me remodels the tumor microenvironment and enhances vaccine therapy for melanoma. Biomaterials. 2015;68:54-66. (IF=8.557)

11. Zou AF, Chen Y, Huo MR*, Wang J, Zhou JP, Zhang Q. In vivo studies of octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles loaded with doxorubicin fortumor-targeted delivery.J Pharm Sci. 2013;102(1):126-35.  (IF=3.007)

12. Huo MR, Zou AF, Yao CL, Zhang Y, Zhou JP, Wang J, Zhu QN, Li J, Zhang Q, Somatostatin receptor-mediated tumor-targeting drug delivery using octreotide-PEG-deoxycholic acid conjugate-modified N-deoxycholic acid-O, N-hydroxyethylation chitosan micelles, Biomaterials, 2012, 33 (27), 6393–6407 (IF=7.604)

13. Li J, Huo MR*, Wang J, Zhou JP*, Jumah Masoud Mohammad, Zhang YL, Zhu QN, Ayman Yahia Waddad, Zhang Q, Redox-sensitive micelles self-assemble from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel, Biomaterials, 2012,33(7), 2310-20 (IF=7.604)

14. Zou AF, Huo MR*, Zhang Y, Zhou JP*, Yin XQ, Yao CL, Zhang Q Octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles as potential carriers for targeted antitumor drug delivery, J Pharm Sci, 2012,101(2),627-40 (IF=3.13)

15. Huo MR, Zhang Y, Zhou JP*, Zou AF, Li J. Formation, microstructure, biodistribution and absence of toxicity of polymeric micelles formed by N-octyl-N,O-carboxymethyl chitosan, Carbohydr Polymer, 2011, 83(4), 1959-69 (IF=3.628)

16. Huo MR, Zhang Y, Zhou JP*, Zou AF, Yu D, Wu YP, Li J. Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug. Int J Pharm. 2010, 15;394(1-2):162-73. (IF=3.607)

17. Zhang Y, Huo MR(co-first author), Zhou JP*, Zou AF, Li WZ, Yao CL, Xie SF. DDSolver: an add-in program for modeling and comparison of drug dissolution profiles. AAPS J.2010;12(3):263-71. (IF=3.942)

18. Li H, Huo MR(co-first author), Zhou JP*, Dai YD, Deng YP, Shi XJ, Masoud J. Enhanced oral absorption of paclitaxel in N-deoxycholic acid-N, O-hydroxyethyl chitosan micellar system, J Pharm Sci. 2010; 99(11): 4543-53 (IF=3.031)

19. Li WZ, Huo MR, Zhou JP*, Zhou YQ, Hao BH, Liu T, Zhang Y. Super-short solid silicon microneedles for transdermal drug delivery applications. Int J Pharm. 2010;389(1-2):122-9. (IF=3.607)

20.Zhang Y, Huo MR(co-first author), Zhou JP, PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel. Comput Methods Programs Biomed. 2010, 99(3):306-14 (IF=1.238)

21. Gong J, Huo MR(co-first author), Zhou JP*, Zhang Y, Peng XL, Yu D, Zhang H, Li J. Synthesis, characterization, drug-loading capacity and safety of novel octyl modified serum albumin micelles. Int J Pharm. 2009 ;376(1-2):161-8. (IF=2.962)

22. Zhang Y, Huo MR*, Zhou JP*, Yu D, Wu YP. Potential of amphiphilically modified low molecular weight chitosan as a novel carrier for hydrophobic anticancer drug: Synthesis, characterization, micellization and cytotoxicity evaluation, Carbohydr Polymer 2009, 77(2), 231-8 (IF=3.167)

23. Huo MR, Zhou JP*, Zhang Y, Lv L, Liu H, Liu FJ. Synthesis, characterization of novel amphiphilic chitosan derivatives and its solubilizing abilities for water-insoluble drugs. Chem. J. Chinese Universities 2007, 28(10): 1995-9  (IF=0.695)


Granted patents

1. Zhou JP, Huo MR, Cui B, Preparation method of albumin nanoparticles encapsulating hydrophobic drugs, Granted Chinese Patent ZL:201110299807.6

2. Zhou JP, Huo MR, Cui B, A kind of albumin nanoparticles encapsulating hydrophobic drugs and its preparation methods, Granted Chinese Patent ZL:201110301807.5

3. Zhou JP, Huo MR, Cui B, A kind of albumin nanoparticles encapsulating paclitaxel and its preparation methods, Granted Chinese Patent ZL:201110299784.9

4.Zhou JP, Huo MR, Li J, Preparation and application of focus triggered-drug release carriers based on amphiphilic polysaccharide, Granted Chinese Patent ZL: 201110048057.5

5. Zhou JP, Huo MR, We Y, Zhang Y, preparation and application of a carrier for solubilization of poorly soluble drugs [P], Granted Chinese Patent ZL: 200610037810.X

6. Zhou JP, Huo MR, Zhang ZF, Wei Y, preparation and application of a compound synthesized by the nonsteroidal antiinflammatory drugs containing carboxyl groups and glucosamine/glucosamine salts [P], Granted Chinese Patent: ZL 200610037811.4