JIANG, CHENG

Release date:2016-05-17  Release:

  

JIANG, CHENG

Associate Professor of Medicinal Chemistry

Deputy Director of Department of Medicinal Chemistry

School of Pharmacy

Phone: 86-25-83271414

Email: jc@cpu.edu.cn

Research Summary

Dr. Jiang’s research focuses on the identification of novel bioactive small molecules and the manufacture process of chemical drugs and intermediates. Based on the structure of protein which has been proved to be the potential target for drug discovery, we make effort to design small molecules that act to the target. After evaluation and further optimization to the lead compound, some drug candidates are hoped to be discovered.


Education

1999       Ph.D., Medicinal Chemistry, China Pharmaceutical University

2002       B.S., Medicinal Chemistry, China Pharmaceutical University

Academic Experience

2010-      Associate Professor of Medicinal Chemistry

2013-2014 Visiting Scholar, Cancer Center, University of Michigan

2007-2010 Assistant Professor of Medicinal Chemistry

Awards and Honors

2008CPA-Servier Young Investigator Awards in Medicinal Chemistry

Publications

  1. Shi, J.M., Lei, M., Wu, W.K., Feng, H.Y., Wang, J., Chen, S.S., Zhu, Y.Q., Hu, S.H., Liu, Z.G., Jiang, C.* Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα- and αβ- amino acids. Bioorg. Med. Chem. Lett., 2016, 26(8): 1958-1962.

  2. Liu, M., Huang, J., Chen, D.X., Jiang, C.* Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg. Med. Chem. Lett., 2015, 25(3): 431-434.

  3. Chen, D.X., Huang, J., Liu, M., Xu, Y.G., Jiang, C.* Design, synthesis, and evaluation of non-ATP-competitive small-molecule Polo-like kinase 1 (Plk1) inhibitors. Arch Pharm., 2015, 348(1): 2-9.

  4. Zhang, J.P., Huang, J., Liu, C., Lu, X.F., Wu, B.X., Zhao, L., Lu, N., Guo, Q.L., Li, Z.Y., Jiang, C.* Discovery of a series of pyridopyrimidine derivatives as potential topoisomerase I inhibitors. Chin. Chem. Lett., 2014, 25(7): 1025-1028.

  5. Chen, J. Y., Levant, B., Jiang, C., Keck, T.M., Newman, A.H. Wang, S. M. Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D3 Receptor Antagonists. J. Med. Chem., 2014, 57(11): 4962-4968.

  6. Chen, J. Y., Jiang, C., Levant, B., Li, X.Q., Zhao, T., Wen, B., Luo, R.J, Sun, D.X., Wang, S. M. Pramipexole Derivatives as Potent and Selective Dopamine D3 Receptor Agonists with Improved Human Microsomal Stability. ChemMedChem, 2014, 9(12): 2653-2660.

  7. Chen, J. Y., Jiang, C., Wang, S. M. LDK378: A Promising Anaplastic Lymphoma Kinase (ALK) Inhibitor. J. Med. Chem., 2013, 56(14): 5673-5674.

  8. Guo, X. K., Sun, H. P., Shen, S., Sun, Y., Xie, F. L., Tao, L., Guo, Q. L., Jiang, C.*, You, Q. D. Synthesis and evaluation of gambogic acid derivatives as antitumor agents. Part III. Chem Biodivers., 2013, 10(1): 73-85.

  9. Jiang, C., You, Q. D. Kinesin spindle protein inhibitors in cancer: a patent review (2008 – present). Exp. Opin. Ther. Pat., 2013, 23(12): 1547-1560.

  10. Jiang, C.; Yang, L.; Wu, W.T.; Guo, Q.L.; You, Q.D. De novo Design, Synthesis and Biological Evaluation of 1,4-Dihydroquinolin-4-ones and 1,2,3,4-Tetrahydroquinazolin-4-ones as Potent Kinesin Spindle Protein (KSP) Inhibitors. Bioorg. Med. Chem., 2011, 19(18): 5612-5627.

  11. Jiang, C.; Yang, L.; Wu, W.T.; Guo, Q.L.; You, Q.D. Antiproliferative and Apoptotic Activities of a Novel Benzimidazole Compound with potent Kinesin Spindle Protein ATPase inhibitory activity. J. Pharm. Pharmcol., 2011, 63(11): 1462-1469.