LIN, AIJUN

Release date:2016-05-17  Release:

LIN, AIJUN

Associate Professor of Medicinal Chemistry

Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University

Phone: 86-25-83271042

Email: ajlin@cpu.edu.cn


Research Summary

Research in LIN’s lab seeks to bring the power of modern synthetic organic chemistry to bear on problems in biology and medicine. The main focus of his research involves synthesis of organic molecules that are biologically interesting. Subsequent mode of action studies of these molecules would provide opportunities for biological insights. He recently published a paper entitled “Solvent-Controlled Switchable C−H Alkenylation of 4 Aryl 1H pyrrole-3-carboxylates: Application to the Total Synthesis of (±)-Rhazinilam”.


Education

2005-2011       Ph.D.,   Organic Chemistry, Nanjing University

Academic Experience

2014-now     Associate Professor of Medicinal Chemistry, China Pharmaceutical University

2012-2014     Postdoctoral research associate of Organic Chemistry, Texas A&M University

2011-2012     Postdoctoral research associate of Organic Chemistry and Pharmacy, Nanjing University

Selected publications:

  1. Xuanyi Li, Xiuyan Xu, Weiwei Wei, Hequan Yao*, Aijun Lin*. Organo-
    catalyzed Asymmetric 1,6-Conjugate Addition of para-Quinone Methides with Dicyanoolefins.
    Organic Letters2016, 18, 428-431.

  2. Youzhi Wu, Peng Sun, Kaifan Zhang, Tie Yang, Hequan Yao*, Aijun Lin*. Rh(III)-Catalyzed Redox-Neutral Annulation of Primary Benzamides with Diazo Compounds: Approach to Isoquinolinones. The Journal of Organic Chemistry2016, 81, 2166-2173.

  3. Hui Jiang, Shang Gao, Jinyi Xu, Xiaoming Wu, Hequan Yao*, Aijun Lin*. Multiple Roles of the Pyrimidyl Group in the Rhodium-Catalyzed Regioselective Synthesis and Functionalization of Indole-3-carboxylic Acid Esters. Advanced Synthesis & Catalysis2016, 358, 188-194.

  4. Peng Sun, Youzhi Wu, Yue Huang, Xiaoming Wu, Jinyi Xu, Hequan Yao*, Aijun Lin*. Rh(III)-catalyzed redox-neutral annulation of azo and diazo compounds: one-step access to cinnolines. Organic Chemistry Frontiers 2016, 3, 91-95.

  5. Shang Gao, Chi Yang, Yue Huang, Lei Zhao, Xiaoming Wu, Hequan Yao*, Aijun Lin*. Pd(II)-catalyzed intramolecular oxidative Heck dearomative reaction: approach to thiazole-fused pyrrolidinones with a C2-azaquarternary center. Organic & Biomolecular Chemistry 2016, 14, 840-843.

  6. Zhenbo Yuan, Xinxin Fang, Xuanyi Li, Jie Wu, Hequan Yao*, Aijun Lin*. 1,6-Conjugated Addition-Mediated [2+1] Annulation: Approach to Spiro[2.5]octa-4,7-dien-6-one. The Journal of Organic Chemistry2015, 80, 11123-11130.

  7. Xuanyi Li, Kuo Gai, Zhenbo Yuan, Jie Wu, Hequan Yao*, Aijun Lin *. Organocatalyzed Formal [4+2] Cycloaddition of in situ Generated Azoalkenes with Arylacetic Acids: An Efficient Approachto the Synthesis of 4,5-Dihydropyridazin-3(2H)-ones. Advanced Synthesis & Catalysis2015, 357, 3479-3484.

  8. Peng Sun, Youzhi Wu, Tie Yang, Xiaoming Wu, Jinyi Xu, Aijun Lin* and Hequan Yao*. Synthesis of Heterocycle-fused Pyridine N-Oxides from Oximes and Diazo Compounds via Rh(III)-Catalyzed C-H Activation and Annulation. Advanced Synthesis & Catalysis, 2015, 357, 2469–2473.

  9. Kuo Gai, Xinxin Fang, Xuanyi Li, Jinyi Xu, Xiaoming Wu, Aijun Lin* and    Hequan Yao*. Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides. Chemical Communications, 2015, 51, 15831-15834.

  10. Youla Su, Shang Gao, Yue Huang, Aijun Lin*, Hequan Yao*. Solvent-Controlled C2/C5-Regiodivergent Alkenylation of Pyrroles. Chemistry-A European Journal, 2015, 21, 15820–15825.

  11. Youla Su, Haipin Zhou, Jiaxuan Chen, Jinyi Xu, Xiaoming Wu, Aijun Lin* and Hequan Yao*. “Solvent-controlled Switchable C-H Alkenylation of 4-Aryl 1H-pyrrole 3-carboxylates: Application to the Total Synthesis of (±)-Rhazinilam.” Org. Lett.2014, 16, 4884-4887.

  12. Aijun Lin, Zhi-wei Zhang and Jiong Yang.* “Iron-Catalyzed Reductive Cyclization of 1,6-Enynes.” Org. Lett.2014, 16, 386-389.

  13. Aijun Lin, C. Bryan Huehls, Jiong Yang. “Recent advances in C-H fluorination.” Org. Chem. Front.2014, 1, 434-438.

  14. Haibin Mao, Aijun Lin, Yan Shi, Zhijie Mao, Xuebin Zhu, Weipeng Li, Hongwen Hu, Yixiang Cheng, Chengjian Zhu.* “Construction of Enantiomerically Enriched Diazo Compounds using Diazo Esters as Nucleophiles based on Chiral Lewis Base Catalysis.” Angew. Chem. Int. Ed.,2013, 52, 6288-6292.

  15. Aijun Lin, Jiong Yang*, Mohamed Hashim. “N-Indolyltriethylborate: A useful reagent for synthesis of C3-quaternary indolenines.” Org. Lett., 2013, 15, 1950-1953,

  16. Aijun Lin, Haibin Mao, Xi Zhu, Huiming Ge, Renxiang Tan, Chengjian Zhu*, Yixiang Cheng.* “Organocatalytic Enantioselective Amination of Morita-Baylis-Hillman Carbonates with Masked Ammonia: A Facile Method for the Synthesis of Unprotected -Methylene--Amino Esters.” Chem. Eur. J., 2011, 17, 13676-13679.

  17. Aijun Lin, Haibin Mao, Xi Zhu, Huiming Ge, Renxiang Tan, Chengjian Zhu*, Yixiang Cheng.* “Organocatalytic Asymmetric C-S bond Formation: Synthesis of -Methylene--Mercapto Esters with Simple Alkyl Thiols”. Adv. Synth. Catal., 2011, 353, 3301-3306.

  18. Aijun Lin, Junying Wang, Haibin Mao, Huiming Ge, Renxiang Tan, Chengjian Zhu*, Yixiang Cheng.* “Organocatalytic Asymmetric Michael-Type/Wittig Reaction of Phosphorus Ylides: Synthesis of Chiral -Methylene--Ketoesters”. Org. Lett., 2011, 13, 4176-4179.

  19. Aijun Lin, Ling Fang, Xi Zhu, Chengjian Zhu*, Yixiang Cheng.* “Organocatalytic Enantioselective Sulfenylation of β-Keto Phosphonates: A Convenient Approach to Construct Hetero-Quaternary Stereocenters”. Adv. Synth. Catal., 2011, 353, 545-549.