LIN, KEJIANG
Associate Professor of Medicinal Chemistry
School of Pharmacy
Phone: 86-25-83271445
Email: link@cpu.edu.cn
Research Summary
Dr. LIN’s research focuses on the lead compound discovery and development, by the means of drug design, synthesis, molecular and structural biology. Specifically, based on the receptor structures provided by NMR or X ray, innovative compounds are designed by computer-aided drug design. After synthesis, the biological activities and interactions between drugs and receptors are examined by molecular and structural biology methods. Primarily driven bytrial and error, novel drugs are patented. Recently Dr. LIN eyes on the diseases caused by multi-drug resistant.
Education
2012 Ph.D., Medicinal Chemistry, China Pharmaceutical University
2003 M.S., Medicinal Chemistry，China Pharmaceutical University
Academic Experience
2005- Associate Professor of Medicinal Chemistry, China Pharmaceutical University
Publications
Zhang, Z.; Wu, G.; Wang, C.; Jin, X.; Li, D.; Lin, K., Features of reversible P2Y12 receptor antagonists based on piperazinyl-glutamate-pyridines. Med. Chem. Res. 2016,25 (6), 1204-1215.
Wu, G.; Zhang, Z.; Chen, H.; Lin, K., De novo design of caseinolytic protein proteases inhibitors based on pharmacophore and 2D molecular fingerprints. Bioorg. Med. Chem. Lett. 2015,25 (11), 2345-52.
Lin, K.; Yu, Z.; Yu, Y.; Liao, X.; Huang, P.; Guo, C.; Lin, D., Distinct effects of Cu2+-binding on oligomerization of human and rabbit prion proteins. Acta biochimica et biophysica Sinica 2015,47 (10), 842-50.
LIN, K.-J.; HUANG, Z.-G.; Li, T.; WANG, N.-X.; CHENG, Y.; SHEN, L.-L.; WANG, Y.-T.; LI, H.; YE, B., The structural characteristics of cannabinoid type 1 receptor antagonists. Chem. J. Chinese Universities 2013,34 (5), 1240-1245.
HUANG, Z.-G.; LIN, K.-J.; YIN, H.-P.; YE, B.-P.; WENG, X.-B.; YOU, Q.-D., Virtual Screening and Antibacterial Activity of Novel Inhibitors Targeting the DNA Gyrase with New Mechanism. Chem. J. Chinese Universities 2013,34 (8), 1887-1893.
Huang, Z.; Lin, K.; You, Q., De novo design of novel DNA-gyrase inhibitors based on 2D molecular fingerprints. Bioorg. Med. Chem. Lett. 2013,23 (14), 4166-4171.
LIN, K.-J.; ZHU, D.-J.; LENG, Y.-G.; YOU, Q.-D., Structural Characterization of Human Parathyroid Hormone 1 Receptor. Acta Physico-Chimica Sinica 2012,28 (7), 1783-1789.
Lin, K.; Len, Y.; Feng, J.; Gao, H.; You, Q.; Lin, D., Structure of a novel PTH-related peptide hPTH' and its interaction with the PTH receptor. J. Pept. Sci. 2012,18 (6), 413-417.
Huang, L.; Huang, Z.; Bai, Z.; Xie, R.; Sun, L.; Lin, K., Development and strategies of VEGFR-2/KDR inhibitors. Future Med Chem 2012,4 (14), 1839-52.
