SHEN, YAN

Release date：2016-05-17  Release：

RESUME

Department of Pharmaceutics

China Pharmaceutical University

Nanjing 210009, China

Tel: +86-25-83271305   Fax : +86-25-83301606

E-mail: shenyan19820801@126.com


PERSONAL INFORMATION                                               

Last Name: Shen

First Name: Yan

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Gender: female

Birth Date: 08/01/1982

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EDUCATION                                                              

Ph.D.  in Pharmaceutics, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China, Jun. 2010

Dissertation: Design and evaluations on CD44-targeted hyaluronate self-assembly micellar nanocarriers for antitumor siRNA delivery

Supervior: Professor Jiasheng Tu-leading researcher in pharmaceutics and functional excipients, who is the committee of USP and ChP.

M.D   in Pharmaceutics, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China, Jun. 2007

Dissertation: Studies on Ganciclovir liposome for ocular delivery system

Supervior: Professor Jiasheng Tu

Bachelor in Pharmaceutics, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China, Jun. 2004

Dissertation: Preparation and in vivo evaluation of silybin lecithin complex


EXPERIENCE                                                   

Associate professor, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China, Jul. 2013-present

Lecturer, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China, Jul.

2010-Dec. 2012



RESEARCH                                                  

  • Synthesis and self-assembly of amphiphilic hyaluronate or albumin derivatives and their application as micelle carrier for insoluble drugs

  • Synthesis and evaluation on Poly(γ, L-glutamic acid)-citric acid based nanoconjugate for cisplatin delivery

  • Redox-sensitive micelles for targeted intracellular delivery of anticancer drugs and siRNA co-delivery

  • Synthesis, characterization, biodegradability and biocompatibility of a temperature-sensitive PBLA-PEG-PBLA hydrogel as protein delivery



RESEARCH PROJECTS


As PI:

1. Preparation of triptolide galactose-modified chitosan nanoparticles, Beijing Institute of Chinese Medicine ,2015

2. Study on temperature sensitive nasal spray technology, 2014

3. Designs on the redox-sensitive targeting drug and gene co-delivery based on "intracellular triggered"mechanism, the National Natural Science Funds for Young Scholar(81201182), 2013

4. Designs on the redox-sensitive hypoxia-targeting hypericin and siRNA co-delivery based on "intracellular triggered" mechanism, the Fundamental Research Funds for the Central Universities for cultivation project（JKPZ2013006）,2013

5. Design and evaluation on the Paclitaxel and siRNA / LMHA-PEI-PLGA self-assembly hybrid nanoparticles co-delivery, the Fundamental Research Funds for the Central Universities for Young Scholar（JKQ2011018）,2011


As co-investigator:

  1. Application of the micro environment sensitive cell penetrating peptide based on the reversible regulation of static charge in the functional design of the two affinity carrier material, the National Natural Science Funds for Young Scholar(81501579), 2016.

  2. Design and evaluation of polymeric micelles modified by acid sensitive cells, Natural Science Foundation of Jiangsu Province (BK20150702), 2015.

  3. Designs on the hyaluronic acid coated redox-sensitive targeting drug and gene co-delivery based on "intracellular triggered"mechanism, The Doctoral Fund of Youth Scholars of Ministry of Education of China (20130096120003), 2014

  4. Study on the improvement of the subject of Pharmacopoeia standards, National Pharmacopoeia Commission, 2013.

  5. Establishment of quality standard for injection accessories and functional inspection method, National Pharmacopoeia Commission, 2011.

  6. Design and evaluations on CD44-targeted hyaluronate self-assembly micellar nanocarriers for antitumor siRNA delivery, National Natural Foundation Project (81072588), 2011.

  7. Study on the key technologies of new pharmaceutical excipients development,National Major Scientific and Technological Special Project for “Significant New Drugs Development” during the Twelfth Five-year Plan Period(2011ZX09501-001-06),2011

  8. Preclinical Safety Evaluation of pharmaceutical new excipients. National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2008BAI55B03), 2010

  9. Study on paclitaxel polymeric micelles for injection, Hi-technology Development Program of Jiangsu Province (No159637050), 2010

  10. Novel drug delivery technologies, Key New Drug Innovation Project from the Ministry of Science and Technology of China (No.2009ZX09310004), 2009

  11. Study on multivesicular liposome formulations for the sustained delivery of ropivacaine hydrochloride.

  12. Study on Ornidazole Injection with Higher Sterility Assurance and the Impurity Profiles





PUBLICATIONS                                                      

Book Chapters

  • Targeted Delivery of Small and Macromolecular Drugs (ISBN：142008772X), Editorial Board Member, CRC Press. Taylor & Francis Group press, 2010.

  • Oral Controlled Release Formulation Design and Drug Delivery (ISBN0470253177), Editorial Board Member, A john wiley & sons, inc, publication Press, 2010


Papers

SCI papers

  1. Shen Y, Wang J, Li Y, Tian Y, Sun H, Ouahab A, Tu J, Wang B, Sun C, Co-delivery of siRNA and paclitaxel into cancer cells by hyaluronic acid modified redox-sensitive disulfide-crosslinked PLGA–PEI nanoparticles .RSC Advances, 2015, 5(58): 46464-46479.

  2. Tian Y, Shen Y, Jv M, Synthesis, characterization and evaluation of tinidazole-loaded mPEG–PDLLA (10/90) in situ gel forming system for periodontitis treatment, Drug delivery, 2015: 1-10.

  3. Li Y, Zhang J, Wang B, Tu J, Shen Y, Ouahab A, Co-delivery of siRNA and hypericin into cancer cells by hyaluronic acid modified PLGA-PEI nanoparticles, Drug development and industrial pharmacy, 2015: 1-10.

  4. Li C, Li S, Tu T, Qi X, Xiong Y, Du S, Shen Y, Tu J,Sun C, Paclitaxel-loaded cholesterol-conjugated polyoxyethylene sorbitol oleate polymeric micelles for glioblastoma therapy across the blood-brain barrier, Polymer Chemistry, 2015, 6, (14): 2740-2751.

  5. Yang C, Shen Y, Wang J, Ouahab A, Zhang T, Tu J. Cationic polymer-based micro-emulgel with self-preserving ability for transdermal delivery of diclofenac sodium.Drug Deliv.2015, 22(6): 814-822.

  6. Shen Y, Ling X, Jiang W, Du S, Lu Y, Tu J. Formulation and evaluation of Cyclosporin A emulgel for ocular delivery. Drug Deliv. 2015, 22(7):911-917.

  7. Xu Y, Shen Y, Ouahab A, Li C, Xiong Y, Tu J. Antitumor activity of TNF-α after intratumoral injection using an in situ thermosensitive hydrogel. Drug Dev Ind Pharm. 2015, 41(3): 369-374.

  8. Shi J, Zhang J, Shen Y, Tang L, Zhao J, Tu J, Tian Y, Feng Y.Arginine-stabilized mPEG-PDLLA (50/50) polymeric micelles of docetaxel by electrostatic mechanism for tumor-targeted delivery. Drug Deliv. 2015, 22(2): 168-181.

  9. Xu Y, Shen Y, Jin X, Tu J, Optimization of Ophthalmic Liposome of Ganciclovir by Box-Behnken Design, Lat. Am. J. Pharm, 2014, 33(2): 251-7.

  10. Ouahab A, Shao C, Shen Y, Tu J, Development and characterization of stabilized double loaded mPEG-PDLLA micelles for simultaneous delivery of paclitaxel and docetaxel, Drug Development and Industrial Pharmacy, 2014, 40(7): 860-868.

  11. Li C, Shen Y, Sun C, Nihad C, Tu J.Immunosafety and chronic toxicity evaluation of monomethoxypoly(ethylene glycol)-b-poly(lactic acid) polymer micelles for paclitaxel delivery.Drug Deliv. 2014, 5:1-8.

  12. Xu X, Shen Y, Wang W, Sun C, Li C, Xiong Y, Tu J.Preparation and in vitro characterization of thermosensitive and mucoadhesive hydrogels for nasal delivery of phenylephrine hydrochloride.Eur J Pharm Biopharm. 2014 , 88(3):998-1004

  13. Li C, Sun C, Li S, Han P, Sun H, Ouahab A, Shen Y, Xu Y, Xiong Y, Tu J.Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery.Int J Nanomedicine. 2014 ,9:2089-100.

  14. Ouahab A, Cheraga N, Onoja V, Shen Y, Tu J.Novel pH-sensitive charge-reversal cell penetrating peptide conjugated PEG-PLA micelles for docetaxel delivery: in vitro study.Int J Pharm. 2014 , 466(1-2):233-45.

  15. Shen Y, Minli Jv, Chunmeng Sun, Daquan Chen, and Jiasheng Tu. Ocular pharmacokinetics and bioequivalence study of azithromycin in rabbits by liquid chromatography–tandem mass spectrometry (LC–MS/MS) , Journal of Liquid Chromatography & Related Technologies, 2013, 36:1–16.

  16. Xiong Y, Jiang W, Shen Y, Li H, Sun C, Ouahab A, Tu J. A poly(γ, L-glutamic acid)-citric acid based nanoconjugate for cisplatin delivery. Biomaterials. 2012, 33(29): 7182-7193.

  17. Sun C, Shen Y, Sun D, Hang T, Tu J. Method development and validation for the determination of indiquinoline tartrate, a novel kappa opioid agonist, and its related substances by high-performance liquid chromatography. J Chromatogr Sci. 2012, 50(4):343-8.

  18. Shen Yan, Lu Yang, Jv Minli, Hu Jinshan, Li Qian, Tu Jiasheng. Enhancing effect of Labrasol on the intestinal absorption of ganciclovir in rats. Drug Dev Ind Pharm. 2011, 37(12): 1415-1421.

  19. Shen Yan, Wang Buhai, Lu Yang, Ouahab A, Li Qian, Tu Jiasheng. A novel tumor-targeted delivery system with hydrophobized hyaluronic acid-spermine conjugates (HHSCs) for efficient receptor-mediated siRNA delivery. Int J Pharm. 2011, 414(1-2): 233-243.

  20. Shen Yan, Ji Yuanxin, Xu Shengjie, Chen Daquan, Tu Jiasheng. Multivesicular liposome formulations for the sustained delivery of ropivacaine hydrochloride: preparation, characterization, and pharmacokinetics. Drug Deliv. 2011, 18(5): 361-366.

  21. Shen Yan, Tu Jia-sheng. Rapid, sensitive and selective liquid chromatography- tandem mass spectrometry (LC-MS/MS) method for the quantification of topically applied Azithromycin in rabbit conjunctiva tissues. Journal of Pharmaceutical and Biomedical Analysis.2010,52(1):99-104.

  22. Shen Yan, Tu Jia-sheng. Determination of Preservatives—Benzalkonium Chloride in Clinical Ophthalmic Drops of Azithromycin by High-performance Liquid Chromatography Method. Journal of Zhejiang University SCIENCE B: Biomedicine & Biotechnology, 2009, 10(12):877-882.

  23. Shen Yan, Tu Jia-sheng. Synthesis and Characterization of Low Molecular Weight Hyaluronic acid-based cationic Micelles for efficient siRNA delivery. Carbohydrate Polymers, 20097,7(1): 95-104.

  24. Shen Yan, Tu Jia-sheng, Preparation and ocular pharmacokinetics of ganciclovir liposomes. AAPS Journal, 2007,9(3):E371-7.


AWARDS                                                    

1. 2013, Second Prize of Teaching Achievement in China Pharmaceutical University

2. 2013, Second Prize of Teaching Competition for Young Teachers of China Pharmaceutical University.

MEMBERSHIP                                                             

1. Chinese Pharmaceutical Association, Member (2010-present)

2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Member (2011-present)

3. Editorial member of Journal of Pharmaceutical Research(2014-present)


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