Release date:2016-05-17  Release:



Associate Professor of Pharmaceutical Analysis

School of Pharmacy

Phone: 86-25-83271185


Research Summary

  • Pharmaceutical Analysis (Chemical and Instrumental Analysis), i.e. the qualification and quantification analytical method development and validation for the quality control of chemical drugs and traditional Chinese medicines (TCM);

  • Pharmacokinetic and metabolism study of chemical drugs and TCM;

  • Phytochemical analysis and quality assessment of TCM based on modern instruments i.e. HPLC, LC-QqQ-MS, LCMS-IT-TOF et al;

  • The inherent mechanism study of TCM based on pharmacokinetics. Especially the mechanism study of deintoxication and/or synergism for TCM in the context of drug metabolite enzyme and transport protein.


2010  Ph.D., Pharmaceutical analysis, China Pharmaceutical University

2005 B.S., Chinese Materia Medica analysis, China Pharmaceutical University

Academic Experience

2013-     Associate professor, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China;

2010-2013 Instructor, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.

Awards and Honors

  1. 2015. Third Prize of Teaching Competition for Young Teachers ofNational Medical Colleges and Universities.

  2. 2015. Honorable mention of National Universities Micro-Teaching Competition.

  3. 2015. First Prize of Universities Micro-Teaching Competition of Jiangsu Province

  4. 2011. First Prize of Teaching Competition for Young Teachers of China PharmaceuticalUniversity.


  1. Min Wang, Guangnan Hu, Yuan Tian, Zunjian Zhang*, Rui Song**. Influence of wine-processing on the pharmacokinetics of anthraquinone aglycones and glycosides from rhubarb in hyperlipidemic hamsters. RSC Advances, 2016, 6: 24871-24879.

  2. Pei Yu, Hongcong Qiu, Min Wang, Yuan Tian, Zunjian Zhang*, Rui Song**.In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes. Xenobiotica, 2016, in press.

  3. Min Wang,Yuan Tian, Mengying Lv, Fengguo Xu, Zunjian Zhang*, Rui Song**. Targeted quantitative analysis of anthraquinone derivatives by high-performance liquid chromatography coupled to tandem mass spectrometry to discriminate crude and processed rhubarb samples. Analytical Methods, 2015, 7: 5375-5380.

  4. Wang Min, Fu Jinfeng, Guo Huimin, Tian Yuan, Xu Fengguo, Song Rui*, Zhang Zunjian*. Discrimination of crude and processed rhubarb products using a chemometric approach based on ultrafast liquid chromatography with ion trap/time-of-flight mass spectrometry. Journal of Separation Science. 2015, 38(3):395-401.

  5. Jinfeng Fu, Rui Song*, Min Wang, Huimin Guo, Zunjian Zhang*. Profiling of Components of Rhizoma et Radix Polygoni Cuspidati by High Performance Liquid Chromatography with UV Diode-array Detector and Ion trap/time-of-flight Mass Spectrometric Detection.  Pharmacognosy Magazine. 2015,11 (43): 486-501.

  6. Wang Min, Fu Jinfeng, Lv Mengying, Tian Yuan, Xu Fengguo, Song Rui*, Zhang Zunjian*. Effect of wine processing and acute blood stasis on the serum pharmacochemistry of rhubarb: A possible explanation for processing mechanism. Journal of Separation Science. 2014, 37(18):2499-503.

  7. Guoqiang Liu, Yuan Tian, Geng Li, Lei Xu, Rui Song, Zunjian Zhang*. Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds. Drug Metabolism Disposition, 2013, 41(3): 622-633.

  8. Lei Xu, Rui Song, Jixin Tian, Yuan Tian, Guoqiang Liu, Zunjian Zhang*. Analysis of saikosaponins in rat plasma by anionic adducts-based liquid chromatography tandem mass spectrometry method. Biomedical Chromatography, 2012, 26(7): 808-815.

  9. Lei Xu, Jixin Tian, Rui Song, Guoqiang Liu, Yuan Tian, Zunjian Zhang*. LC-MS/MS determination and comparison of saikosaponin a, b2, c, d in crude and processed radix bupleuri by vinegar. Journal of China Pharmaceutical University (in Chinese), 2012, 43(4): 344-340.

  10. Rui Song,Ying Cheng, Yuan Tian, Zunjian Zhang*. A validated solid−phase extraction HPLC method for the simultaneous determination of gallic acid, catechin and epicatechin in rhubarb decoction. Chinese Journal of Natural Medicines,2012, 10(4): 0275-0278.

  11. Rui Song, Yuan Tian, Zunjian Zhang*.  Comparison of transformation of four processed

rhubarb aqueous extracts in intestinal bacteria in vitro. China Journal of Chinese Materia Medica (in Chinese), 2012, 37(12): 1755-1760.

  1. Rui Song, Lei Xu, Fengguo Xu, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. Metabolic analysis of rhubarb extract by rat intestinal bacteria using liquid chromatograpy-tandem mass spectrometry. Biomedical Chromatography, 2011, 25(3): 417-426.

  2. Rui Song, Lei Xu, Fengguo Xu, Zhe Li, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. In vivo metabolism study of rhubarb decoction in rat using high-performance liquid chromatography with UV photodiode-array and mass spectrometric detection: a strategy for systematic analysis of metabolites from traditional Chinese medicines in biological samples. Journal of Chromatography A, 2010, 1217 (45): 7144-7152.

  3. Rui Song, Lei Xu, Zunjian Zhang*, Yuan Tian, Fengguo Xu, Hanjuan Dong. Determination of gallic acid in rat plasma by LC-MS/MS. Chromatographia, 2010, 71(11/12): 1107-1111.

  4. Fengguo Xu, Ying Liu, Rui Song, Haijuan Dong and Zunjian Zhang*. Constituents of Da-Cheng-Qi Decoction and its Parent Herbal Medicines Determined by LC-MS/MS. Natural Product Communications, 2010, 5(5): 789-794.

  5. Rui Song, Hui Lin, Zunjian Zhang*, Zhe Li, Lei Xu, Haijuan Dong, Yuan Tian. Profiling the metabolic difference of anthraquinone derivatives using liquid chromatography/tandem mass spectrometry with data-dependent acquisition. Rapid Communications in Mass Spectrometry, 2009, 23(4):537-547.

  6. Rui Song, Fengguo Xu , Zunjian Zhang *, Ying Liu , Haijuan Dong, Yuan Tian. Structural elucidation of in vitro metabolites of Emodin by liquid chromatography–tandem mass spectrometry. Biomedical Chromatography, 2008, 22(11):1230-1236.

  7. Fengguo Xu, Ying Liu, Zunjian Zhang*, Rui Song, Haijuan Dong, Yuan Tian. Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction. Journal of Pharmaceutical and Biomedical Analysis, 2008, 47(3):586-595.

  8. Ying Liu, Fengguo Xu, Zunjian Zhang *, Rui Song, Yuan Tian. Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high performance liquid chromatography-tandem mass spectrometry. Biomedical chromatography, 2008, 22(7):736-745.