Release date:2016-05-25  Release:




Associate Professor of Pharmacology

School of Basic Medicine and Clinical Pharmacy

Phone: 86-25-86185226

Email: jihua_fu@cpu.edu.cn

Research Summary

Jihua Fu’s research focuses on the molecular mechanisms oftype 2 diabetes mellitus, metabolism syndrome, and hyperlipoidemiaowing to insulin resistance (IR). He recently published four papers entitled "Long-term Stress with Hyperglucocorticoidemiainduced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver”,Important role of 5-hydroxytryptamine in glucocorticoid-induced insulin resistance in liver and intra-abdominal adipose tissue of rats”, “5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats”, and “Effective treatment with combination of peripheral 5-hydroxytryptamine synthetic inhibitor and 5-hydroxytryptamine 2 receptor antagonist on glucocorticoid-induced wholebody insulin resistance with hyperglycemia”, which consider that those IR-related diseases, by inducing Hyperglucocorticoidemiain and/orhigh level of blood free fatty acids, lead to abnormality of peripheral 5-HT (also known as serotonin) system, including increased 5-HT synthesis and upregulated 5-HT 2 receptors expression, which is crucial in hepatocellular IR, perhaps also crucial in skeletal muscele and adipose tissue IR. The further investigation involved in signaling pathway has obtained novel discovery in hepatocytes, which is the first time in the world. This research item was supported by the National Natural Science Foundation of China (No. 81570720) in 2015.


2010   Ph.D., Pharmacology, China Pharmaceutical University

1983   B.S., Animal PhysiologyBeijing University

Academic Experience

1996-This day   Associate Professor of Pharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University

1990-1995   Lecturer of Pharmacology, School of Pharmacy, China Pharmaceutical University

1983-1989   Assistant of Pharmacology, School of Pharmacy, China Pharmaceutical University


  1. Jihua Fu*, Shaoxin Ma, Xin Li, et al. Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver. International Journal of Biological Sciences, 2016; 12(2): 219-234. (SCI)

  2. Tao Li, KekeGuo, ……, Jihua Fu*. Important role of 5-hydroxytryptamine inglucocorticoid-induced insulin resistance inliver and intra-abdominal adipose tissue of rats. J Diabetes Investig, 2016; 7(1): 32-41. (SCI)

  3. Xin Li, Keke Guo, ……, Jihua Fu*. 5-HT 2 receptor mediates high-fatdiet-induced hepatic steatosis and verylow density lipoprotein overproductionin rats. Obesity Research & Clinical Practice, 2016; http://dx.doi.org/10.1016/j.orcp.2016.03.015. (SCI)

  4. Shaoxin Ma,TaoLi,……, Jihua Fu*. Effective treatment with combination ofperipheral 5-hydroxytryptamine syntheticinhibitor and 5-hydroxytryptamine 2 receptorantagonist on glucocorticoid-induced wholebody insulin resistance with hyperglycemia. J Diabetes Investig, 2016; doi:10.1111/jdi.12526. (SCI)

  5. Shudong Wang,Tao Li,……, Jihua Fu*. The Effects of Xiangqing Anodyne Spray onTreating Acute Soft-Tissue Injury Mainly Depend onSuppressing Activations of AKT and p38 Pathways. Evidence-Based Complementary and Alternative Medicine, 2016; http://dx.doi.org/10.1155/2016/9213489. (SCI)

  6. Ying Han, Min Lin, ……, Jihua Fu*. Basis of aggravated hepatic lipid metabolism by chronic stressin high-fat diet-fed rat. Endocrine (2015) 48:483–492. (SCI)

  7. Shudong Wang, Wei Qu, ……, Jihua Fu*. Xiangqing anodyne spray (XQAS): a combination of ethanol extracts of Cynanchum paniculatum and Illicium henryi for treating soft-tissue injury. 2015; 8(8):12716-12725. (SCI)

  8. Siyuan Gao, Xue Han, Jihua Fu*, et al.Influence of chronic stress on the compositions of hepatic cholesterol and triglyceride in male Wistar rats fed a high fat diet. Hepatology Research, 2012; 42: 686–695. (SCI)