GUO, QINGLONG

Release date:2016-05-18  Release:


 

GUO, QINGLONG

Professor of Pharmacology

Dean of School of Basic Medicine and Clinical Pharmacy

Directorof JiangsuKey Laboratory of Carcinogenesis and Intervention

School of Basic Medicine and Clinical Pharmacy

Phone: 86-25-83271055

Email: qinglongguo@hotmail.com

Research Summary

Prof. Guo is mainly engaged in the tumor pathogenesis and natureantitumor drug discovery research. His mainly studies are foucued on the belowaspacts:

1) Based on the etiology and pathogenesis of cancer stem cells in cancer, study thedifferent signals between cancer stem cell and normal stem cell growth anddifferentiation; clarify the regulation target protein and exact molecular mechanismand search for drug candidates targeting cancer stem cells.

2) Study the effectiveness, targets and mechanism of nature cancer drugs involving inangiogenesis, tumor metastasis, signal transduction and cell apoptosis; and providetheoretical basis for clinical cancer therapy.

3) Reveal the structure and function of the tumor signal transduction pathways andnetwork, and search for the potential new targets ofanti-tumor drugs through theapplication of chemical biology research means.


Education

1984  Ph.D., Pharmacology, China Pharmaceutical University

1984  B.S., Animal ScienceNorthwest Agricultural University


Academic Experience

2004-      Professor of Pharmacology, China Pharmaceutical University

1998-2004  Associate Professor of Pharmacology, China Pharmaceutical University

1984-1998  Lecturer of PharmacologyChina Pharmaceutical University

Awards and Honors

2015  Jiangsu Provincial Science and Technology Progress Award, Technology Gallery of Jiangsu Province

2014 Young and middle-aged Expert with Outstanding Contribution of Jiangsu ProvincePeople's Government of Jiangsu Province

2013" 333 high - level talents training project " Young chief scientist in Jiangsu, Jiangsu Provincial Office of Personnel

2007Six talents peak ( Class A ) - funded project in Jiangsu Province, Jiangsu Provincial Personnel Department

2006  Jiangsu Province " outstanding educator ", People's Government of Jiangsu Province

2005University " Blue Project " young academic leaders in Jiangsu, Education Department of Jiangsu Province


Recent Representative Publications

1Yan Chen, Hui Hui, Hao Yang, Kai Zhao, Yansu Qin, Cong Gu, Xiaotang Wang, Na Lu, and Qinglong Guo*. Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells. Blood. 2013 May 2;121(18):3682-91 (IF10.558)

29Lei Qiang, Tian Wu, Hai-Wei Zhang, Na Lu, Rong Hu, Ya-Jing Wang, Li Zhao, Fei-Hong Chen, Xiao-Tang Wang, Qi-Dong You, Qing-Long Guo*. HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. Cell Death and Differentiation. 2012;19(2):284-94. (IF8.849)

3Xuefen Xu, Xiaobo Zhang, Yicheng Liu, Lin Yang, Shaoliang Huang, Lu Lu, Shuhao Wang, Qinglong Guo*, Li Zhao*. BM microenvironmental protection of CML cells from imatinib through Stat5/ NF-κB signaling and reversal by Wogonin. Oncotarget 2016.March 24. (IF6.385)

4Xiaoping Wang, Y angSun , Yue Zhao, Youxiang Ding , Xiaobo Zhang , Lingyi Kong , Zhiyu Li , , Qinglong Guo*,  Zhiyu Li*. Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation. Biochem Pharmacol. 2016 Apr 15;106:70-81. doi: 10.1016/j.bcp.2016.02.019. Epub 2016 Mar 4  (IF5.008)

5Lin Yang1, Yinan Yuan1, Chengyu Fu, Xuefen Xu, Jieying Zhou, Shuhao Wang, Lingyi Kong, Zhiyu Li, Qinglong Guo*, Libin Wei*. LZ-106, a novel analog of enoxacin, inducing apoptosis via activation of ROS-dependent DNA damage response in NSCLCs. Free Radical Biology and Medicine. 2016. (IF 5.736)

6Li Zhao, Wei Li, Yuxin Zhou, Yi Zhang, Shaoliang Huang, Xuefen Xu, Zhiyu Li  and Qinglong Guo*.  The overexpression and nuclear translocation of Trx-1 during hypoxia confers HepG2 cells resistance to DDP and GL-V9 reverses the resistance by suppressing Trx-1/Ref-1 axis. Free radical biology & medicine, 2015.82 :p.29-41 (IF 5.736)

7Libin Wei, Yuxin Zhou, Jing Yao, Chen Qiao, Ting Ni, Ruichen Guo, Qinglong Guo* and Na Lu*.Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor. Oncotarget. 2015 Jun 30;6(18):16198-214. (IF6.46)

8Libin Wei, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li,  Qidong You*, Qinglong Guo* , Na Lu*. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death & Disease.2015. Apr 9;6:e1714 (IF 5.133)

9Zhao Li, Miao Hanchi, Li Wenjun, Sun Yang, Li Zhiyu, Qinglong Guo*. LW-213 induces G2/M cell cycle arrest through Akt/Gsk3β/β-catenin signaling pathway in human breast cancer cells. Molecular Carcinogenesis.2015 May 6 ( IF 4.808)

10Yang Sun, Yue Zhao, Jing Yao, Li Zhao, Zhaoqiu Wu, Yu Wang, Di Pan, Hanchi Miao, Qinglong Guo*, Na Lu* Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation. Biochemical  Pharmacology 2015 Mar 15;94(2):142-54. (IF 5.009)

11Hui Li, Hui Hui, Jingyan Xu, Hao Yang, Xiaoxiao Zhang, Xiao Liu, Yuxin Zhou, Zhiyu Li, Qinglong Guo*, and Na Lu*.Wogonoside Induces Growth Inhibition and Cell Cycle Arrest via Promoting the Expression and Binding Activity of GATA-1 in Chronic Myelogenous Leukemia Cells. Archives of Toxicology. 2015 Jun 24, pp 1-16 (IF 5.98)

12Yujie Huang, Kai Zhao, Yang Hu, Yuxin Zhou,Xuwei Luo, Xiaorui Li, Libin Wei, Zhiyu Li,Qidong You, Qinglong Guo* and Na Lu* Wogonoside Inhibits Angiogenesis in Breast Cancer Via Suppressing Wnt/b-Catenin Pathway. Molecular Carcinogenesis, 2015 Sep 20 ( IF 4.808)

13Xin Li, Hanchi Miao, Yi Zhang, Wei Li, Zhiyu Li, Yuxin Zhou, Li Zhao*, Qinglong Guo*. Bone  marrow  microenvironment  confers  imatinib resistance  to  chronic myelogenous  leukemia  and  oroxylin  A  reverses  the  resistance  by  suppressing  Stat3 pathway. Archives of Toxicology. 2015 Jan;89(1):121-36IF: 5.2

14Jing Yao, Li Zhao, Qing Zhao, Yue Zhao, Yang Sun, Yi Zhang, Hanchi Miao, Qidong You*, Qinglong Guo*.NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition on inflammation-associated colorectal carcinogenesis Cell Death & Disease 2014 Jun 5;5:e1283. (IF: 5.13)

15、、Hui Hui, Yan Chen, Hao Yang, Kai Zhao, Qian Wang, Li Zhao, Xiaotang Wang, Zhiyu Li, Na Lu* and Qinglong Guo*.Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα. Int J Cancer. 2014 Mar 1;134(5):1195-206 IF 6.113