LI, YUNMAN

Release date:2016-05-18  Release:

LI, YUNMAN

Professor of Pharmacology

DeputyDirector of Basic Medicine,

School of Basic Medicine and Clinical Pharmacy

Phone: 025-83271173(O),

E-mail:yucaoren@sina.com

Research Summary

1. Cardiovascular and Cerebrovascular Pharmacology

The object of our study is to research and developoriginal new drug in these areas and to explore important therapeutic target. For example, we focus on glycogen phosphorylase to research the protective effects and mechanisms of glycogenphosphorylaseinhibtors on myocardial ischemia.On the other hand, we also investigate that the neuroprotective effects of neurons and microglia through a series ofbiochemical process alteration under cerebral ischemia.  

2. Tumor Multidrug-Resistance Reversing Pharmacology

We investigate tumor multidrug-resistance (MDR) signal transduction pathway induced by ATP-bindingcassette transporter (ABC) and apoptotic protein and explore essential qualities of ABC and apoptotic protein MDR. Furthermore, we will study new multidrug resistance reversing agents based on above thesis, which provide new thought to conquer tumor multidrug resistance.

Education

2005Ph.D.,Pharmacology, China Pharmaceutical University

1982  B.S., Medicine, Shandong Medical University

Academic Experience

I work in Physiological department, College of Pharmacy in China Pharmaceutical University from 1982. In teaching, I mainly instruct Anthropotomy and Physiology, Pharmaceutical and Medical Base courses to undergraduates. In addition, I teach Present Pharmacology and Recent Advance in Pharmacology lessons to graduate students for many years.

Award and Honors

1. Advanced Worker of Jiangsu Pharmacology Society. 2015

2. Excellent quality course of Jiangsu province. 2014.

3. Excellent scientific book of Eastern Technology Press. 2014.

4. Excellent Graduate Thesis of Master Degree. 2011. (Tutor)

5. Excellent Editor for Journal of China Pharmaceutical University. 2009

6. Most Cited Chinese Papers. 2008. Protective effects of scutellarin and borneolum injection on experimental cerebral ischemia in animals. Corresponding author

7. Second kind of excellent quality course of China Pharmaceutical University. 2006. Ranking 3rd.

8. Third prize of multi-media courseware of Tiankong Jiaoshi Bei of Jiangsu. 2006. Ranking 2nd.

9. Second prize of excellent multi-media courseware of China Pharmaceutical University. 2006. Ranking 1st.

10. First prize of excellent multi-media courseware of China Pharmaceutical University. 2005. Ranking 3rd.

11. Science and Technology Production Identification Certificate of Jiangsu Province. 2004.10. Ranking 3rd.

12. Science and Technology Production Finisher Certificate of Ministry of Education. Take charge of pharmacology

13. Certificate of honor in science and technology of China Pharmaceutical University from 2001 to 2004.

14.Excellent Editor for Chinese Pharmacological Bulletin

15. Second Excellent Course of China Pharmaceutical University. Ranking 2nd.

Publications

Papers and articles:

1. Lijian Yang, Xi Chen, Siqi Wang, Yuxiang Fei, Ding Wang, Yunman Li, Guangwei He, Qiang Wu, Shaoxing Chu, Weirong Fang. N2 extenuates experimental ischemic stroke through platelet aggregation inhibition.Thromb Res. 2015 Dec;136(6):1310-7. (Corresponding author)

2. Dan Han, Weirong Fang, Rui Zhang, Jie Wei, Nandani Darshika Kodithuwakkua, Lan sha, Wenhuan Ma, Lifang liu, Fengwen Li, Yunman Li. Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20. Brain,Behavior and Immunity. 2016 Jan;51:56-69. (Corresponding author)

3. Yisong Qian, Menghao Huang, Teng Guan, Lan Chen, Liangxun Cao, Xiao-Jian Han, Longfei Huang, Xuzhen Tang, Yunman Li, Hongbin Sun. Maslinic acid promotes synaptogenesis and axon growth via Akt/GSK-3β activation in cerebral ischemia model. European journal of pharmacology. 2015 Oct 5;764:298-305. (Corresponding author)

4. Jinru Huang, Nandani Darshika Kodithuwakkua, Wei He, Yi Zhou, Wenxiang Fan, Weirong Fang, Guangwei He, Qiang Wu, Shaoxing Chu, Yunman Li. The neuroprotective effect of a novel agent N2 on rat cerebral ischemia associated with the activation of PI3K/Akt signaling pathway. Neuropharmacology.2015 Aug;95:12-21. (Corresponding author)

5. Weirong Fang, Lan Sha,Nandani Darshika,Jie Wei,Rui Zhang,Dan Han,Yunman Li. Attenuated Blood-Brain Barrier Dysfunction by XQ-1H Following Ischemic Stroke in Hyperlipidemic Rats. Molecular biology. 2015 Aug;52(1):162-75. (Corresponding author)

6. Clematichinenoside attenuates myocardial infarction in ischemia/reperfusion injury both in vivo and in vitro.Wei J, Fang W, Sha L, Han D, Zhang R, Hao X, Li Y. XQ-1H Suppresses Neutrophils Infiltration and Oxidative Stress Induced by Cerebral Ischemia Injury Both In Vivo and In Vitro. Neurochem Res. 2013. Sep;79(14):1289-97. (Corresponding author)

7. Yidong Feng, Yahui Hu, Juan Cen, Kodithuwakku Nandani Darshika, Weirong Fang, Yunman Li, Wenlong Huang. HZ08 inhibits the multi-drug resistance on multiple sites as the substrate of p-glycoprotein. Eur J Pharmacol. 2013 Jul 15;712(1-3):53-9. (Corresponding author)

8. Yang Q, Fang W, Lv P, Geng X, Li Y, Sha L.Therapeutic neuroprotective effects of XQ-1H in a rat model of permanent focal cerebral ischemia. Pharmacology. 2012;89(1-2):1-6. (Corresponding author)

9. Longfei Huang, Teng Guan, Yisong Qian, Yunman Li, Hongbin Sun.Anti-inammatory effects of maslinic acid, a natural triterpene, in cultured corticalastrocytes via suppression of nuclear factor-kappa B. Eur J Pharmacol. 672 (2011) 169–174.(Corresponding author)

10. Peng C, Perera PK, Li YM, Fang WR, Liu LF, Li FW.Anti-inflammatory effects of Clematis chinensis Osbeck extract(AR-6) may be associated with NF-κB, TNF-α, and COX-2 in collagen-induced arthritis in rat.  Rheumatology International: Volume 32, Issue 10 (2012), Page 3119-3125. (Corresponding author)

11. Jing Xiong, Li Bai, Wei Fang, Jianyang Fu, Weirong Fang, Juan Cen, Yi Kong, Yunman Li,. New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuatingAkt phosphorylation. European Journal of Pharmaceutical Sciences.45 (2012) 552–558.(Corresponding author)

12. Menghao Huang 1, Yisong Qian 1, Teng Guan 1, Longfei Huang, Xuzhen Tang, Yunman Li.Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo. European Journal of Pharmacology 677 (2012) 71–76.(Corresponding author)

13. Qichuan YangWeirong Fang Peng LvXiaohan Geng Yunman Li,    Lan Sha. Therapeutic Neuroprotective Effects of XQ-1H in a Rat Model of Permanent Focal Cerebral Ischemia.Pharmacology  2012;89:1–6.(Corresponding author)

14. Y-LZhu,JCen, Y-Y Zhang  , Y-D Feng, YYang , Y-MLi, W-L,   Huang.The Multidrug Resistant Modulator HZ08 Reverses Multidrug Resistance via P-glycoprotein Inhibition and Apoptosis Sensitization in Human Epidermoid Carcinoma Cell Line KBv200. Bibliography. February 16, 2012.(Corresponding author)

15. Zhen X, Cen J, Li YM, Yan F, Guan T, Tang XZ.Cytotoxic effect and apoptotic mechanism of tanshinone A, a novel tanshinone derivative, on human erythroleukemic K562 cells.Eur J Pharmacol. 2011;667(1-3):129-35. (Corresponding author)

16. Cen J, Zhu YL, Yang Y, Zhu JR, Fang WR, Huang WL, Li YM, Tao YF. Effects of the multidrug resistance modulator HZ08on the apoptosis pathway in human chronicleukaemia cell line K562/A02. Arzneimittelforschung. 2011;61(11):1-9. (Corresponding author)

17. Fang W, Geng X, Deng Y, Li Y, Shang E, Cen J, Lv P: Platelet activating factor induces blood brain barrier permeability alteration in vitro. J Neuroimmunol, 2011, 230(1-2):42-47.(Corresponding author)

18. Qian Y, Guan T, Tang X, Huang L, Huang M, Li Y, Sun H, Yu R, Zhang F. Astrocytic glutamate transporter-dependent neuroprotection against glutamate toxicity: an in vitro study of maslinic acid.Eur J Pharmacol. 2011;651(1-3):59-65. (Corresponding author)

19. Qi Yan, Bai Li, Lv Peng, Fang Wei-rong,LI Yun-man. The therapeutic time window of Ginkgolide Bmesylate in permanent focal ischemia in rat.Journal of China Pharmaceutical University. 2010, 41(2): 166-170. (Corresponding author)

20. LI Yun-ManWANG Hai-YanLIU Guo-Qing.Erianin induces apoptosis in human leukemia HL-60 Cell [J]. Acta Pharmacol Sin. 2001 Nov22(11)1018-1022.(Corresponding author)

21. Weirong Fang, Yun-Man Li, Ying Cai et al, Ying Cai, Kai Kang, Fang Yan, Guoqing Liu, Wenlong Huang. Substituted tetrahydriosoquinoline compound B3 inhibits P-glycoprotein-mediated multidrug resistance in vitro and in vivo. Journal of Pharmacy and Pharmacology .2007.591649-1655. (Corresponding author)

22. Fang Yan, Yi Jiang, Yun-Man Li, et al. Reversal of P-glycoprotein and Multidrug resistance-associated protein 1 mediated multidrug resistance in cancer cells by HZ08 isomers, Tetrataisohydroquinolin derivatives. Biological & Pharmaceutical Bulletin. 2008.3161258-1264.(Corresponding author)

23. Yan Fang, Li Yun-Man, Wang Qiu-juan et al. Effects of HZ08, a novel P-glycoprotein inhibitor, on the reversal of P-glycoprotein mediated multidrug resistance in nude mice and cytochrome P-450 activities in rat liver microsome. Journal of Pharmaceutical University .2008, 39(5): 447-452. (Corresponding author)

24. Xiong J, Fang W, Fang W, Bai L, Huo J, Kong Y, Yunman L. Anticoagulant and antithrombotic activity of a new peptide pENW (pGlu-Asn-Trp).Journal of Pharmacy and Pharmacology. 2009 Jan;61(1):89-94.(Corresponding author)

25. Yan Deng, Weirong Fang, Yunman Li, Juan Cen, Fang Fang, Peng Lv, Shubo Gong, Lishun Mao. Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. European Journal of Pharmacology, 2009, 616 (1-3): 43-47. (Corresponding author)

26. Guan T, Li Y, Sun H, Tang X, Qian Y. Effects of maslinic acid, a natural triterpene, on glycogen metabolism in cultured cortical astrocytes. Planta Med.2009; 75(10):1141-3. (Corresponding author)

27. Fang W, Deng Y, Li Y, Shang E, Fang F, Lv P, Bai L, Qi Y, Yan F, Mao L. Blood brain barrier permeability and therapeutic time window of Ginkgolide B in ischemia-reperfusion injury. Eur J Pharm Sci. 2010. 31; 39(1-3):8-14.(Corresponding author)

28. Yao Z, Gong S, Guan T, Li Y, Wu X, Sun H. Synthesis of ranolazine metabolites and their anti-myocardial ischemia activities. Chem Pharm Bull (Tokyo). 2009; 57(11): 1218-22.(Corresponding author)

29. Sun SX, Li YM, Fang WR, Cheng P, Liu L, Li F. Effect and mechanism of AR-6 in experimental rheumatoid arthritis.Clin Exp Med. 2010;10(2):113-21.

30. Yi Kong, Jian-li Huo, Wen Xu, Jin Xiong, Yun-man Li, Wu-tong Wu. A novel anti-platelet aggregation tripeptide from Agkistrodon acutus venom:Isolation and characterization. Toxicon. 54(2009): 103-109.

31. GONG Shu-bo, LI Yun-man, FANG Wei-rong, Lv Peng, GU Wei, SHEN Xiao-lan. Effect of Trichosanthes kirilowii Allium macrostemon injection on acute myocardial ischemia and hemodynamic parameters in dogs. Chinese Journal of New Drugs. 2009; 18(22): 2155-2159.

32. Lü Xue, FANG Wei-rong, LI Yun-man, LIU Li-fang, LI Feng-wen. Analgesic and anti-inflammatory effect of clematichinenoside. Chinese Journal of New Drugs. 2009, 18 (16): 1535-1539.

33. LI Te; LI Yun-man; LIU Li-fang; WANG Xin-yu; LI Feng-wen; ZHU Xing-xiang. Mechanism of total saponins of Radix Clematidis on rheumatoid arthritis.Journal of China Pharmaceutical University . 40(2): 157-160.

34. DENG Yan; LI Yun-man; FANG Wei-rong; CEN Juan. Protective effect of RNGB on rat brain microvessel endothelial cell [J]. Pharmaceutical and Clinical Research. 2009, 17(2): 96-99. (Corresponding author)

35. Li Yun-Man,Zhu Hao-Jie,Liu Guo-Qing.Shikonin Inhibiting the Catalytic Activity of DNA Topoisomerase I and Inducing the Apoptosis of K562 Leukemia Cell [J]. Chin J Nat Med .Sep 2003, 1(3): 165-168.

36. LI Yun-Man; CAI Ying; YANG Gui-Cheng.Effect of Lomerizine on Multidrug Resistance in Human Leukemic Cell Line K562/A02. Journal of China Pharmaceutical University. 2003, 34(4): 360-364.

37. LI Yun-Man; CHEN Fang-Ping; LIU Guo-Qing. Studies on Inhibitive Effect of Gastrodin on PC12 Cell Damage Induced by Glutamate and H2O2 [J].Journal of China Pharmaceutical University. 2003, 34(5): 456-460.

38. LI Yun-Man; TANG Ming-Yue ; XIA Wen; LI Te.Antitumor Effect of D-Glucosamine Hydrochloride in Mice [J]. Chinese Journal of Natural Medicines. 2003, 1 (4): 237-237.

39. LI Yun-Man; LEI Zhi-Gang; YANG Gui-Cheng. Comparative Antihyperlipidemic Effects of Simvastatin and Lovastatin [J]. Journal of China Pharmaceutical University. 2002, 33(5): 448-50.

40. LI Yun-Man; LIU Jian-Ping 1; LING Xiang-Ping; SUN Yu. Pharmacodynamic Study of Antitussive and Antiasthmatic Film Ⅱ. Therapeutic Action and Its Action Mechanism on Chronic Bronchitis In Mice [J]. Journal of China Pharmaceutical University. 2001. 32(6): 436-9.

41. CAI Ying; LI Yun-Man; ZHONG Liu. Effect of Amygdalin on Gastric Ulcer in Experimental Models [J]. Journal of China Pharmaceutical University. 2003, 34(3): 254-256.  

42. CHEN Fang-ping; LI Yun-man; LIU Guo-qing. Research and Development of 5-HT (1A) Receptor Agonists, a New Class of Antidepressants [J]. Progress In Pharmaceutical Sciences. 2003, 24(4): 213-216.  (Corresponding author)

42. Wang Haiyan Li Yunman Liu Guoqing. Advances in Study on Mechanism of Resistance to Taxol [J]. PROGRESS IN PHARMACEUTICAL SCIENCES. 1999. 23(5): 277-280. (Corresponding author)

43. KANG Kai; LI Yun-man. Advances in Inhibitor of P-Glycoprotein [J]. Progress In Pharmaceutical Sciences. 2004, 28(9): 405-8.(Corresponding author)

44. FANG Wei Rong 1; LI Yun Man; ZHONG Lin Lin. Experimental study of effects of amygdalin on adjuvant inflammatory [J]. Chinese Journal of Clinical Pharmacology and Therapeutics. 2004, 3: 289-93.(Corresponding author)

45. DENG Jia-Yuan; LI Yun-Man; LU Lin-Lin. Effect of Amygdalin on Chronic Gastritis and Chronic Atrophic Gastritis [J]. Journal of China Pharmaceutical University. 2002, 33(1): 45-7.  (Corresponding author)

46. YANG Yang; LI Yun-man; FANG Wei-rong; LIANG Ying; XU Ye. The Effect of Astragalus Extract on Heart Failure in Dogs [J].Progress In Pharmaceutical Sciences. 2005, 29(3): 122-128. (Corresponding author)

47. SUN Yu; LI Yun-Man; XIA Ren-Rui; CUI Li; WU Wu-Tong.Effect of Recombinant Hirudin on Cataract in Experimental Models [J]. Journal of China Pharmaceutical University. 2005, 36(3): 260-262. (Corresponding author)

48. JIANG Yi; LI Yun-man.Relationship between Glutathione and related enzymes and multidrug resistance [J].Chinese Journal of Clinical Pharmacology and Therapeutics. 2005, 10(10): 1086-1091.  

49. Fang Wei-rong; Li Yun-man; Deng Jia-yuan.Protective effect of sanguis draxonis flavones on animal myocardial ischemia. Chinese Journal of Clinical Pharmacology and Therapeutics. 2005, 10( 3): 1020-1024.(Corresponding author)

50. Angue Nkoghe Francoise and Yunman Li. Advances in the study Alzheimeis disease [J].Journal of Nanjing Medical University. 2005, 19(6): 279-283. (Corresponding author)

51. HU Miao-miao; LI Yun-man.Nitric oxide synthase inhibitors and cerebral ischemia [J].Chinese Journal of Clinical Pharmacology and Therapeutics. 2006, 11(1): 10-13.  (Corresponding author)

52. GONG Xiao-Jian; LI Yun-Man; AN Bai-Pin; LIU Guo-Qing.Effect of Total Flavonoids of Rhizoma Drynariae on Experimental Knee Osteoarthritis [J]. Chinese Journal of Natural Medicines. 2006, 4(3): 215-218. (Corresponding author)

53. Li Te, Li Yunman. Advancesin anti rheumatoid arthritis drugs [J].Jiangsu Pharmaceutical and Clinical Research. 2006. 14(2): 88-91. (Corresponding author)

54. Wu Yu-lin, Fang Wei-rong, Li Yun-man. OptimizingTeaching Content toImprove Teaching Quality [J].Central South Pharmacy. 2006, 4(2): 158-160. (Corresponding author)

55. KANG Kai; LI Yun-man; JIANG Yi; FANG Wei-rong.Establishment of Three Melanoma Animal Models [J]. Progress in Pharmaceutical Sciences. 2006, 30(7): 326-329. (Corresponding author)

56. DENG Jia-Yuan; LI Yun-Man; FANG Wei-Rong.Protective Effect of Sanguis Draconis Flavones on Cell Injury in Primary Cultured Cardiac Myocytes [J]. Chinese Journal of Natural Medicines. 2006, 4(5): 373-376. (Corresponding author)

57. GONG Xiao-jian; LI Yun-man~1; BIAN Hui-min; FANG Wei-rong~1; LIU Guo-qing. Effects of total ginkgolides counteract platelet aggregation and experimental thrombosis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics. 2006, 11(7): 822-825. (Corresponding author)

58. KANG Kai; LI Yun-man; FANG Wei-rong; JIANG Yi; ZHANG Lu-yong.Prolonging Treatment with Lomerizine May Increase Chemosensitivity of K562/A02 to Adriamycin [J]. Progress in Pharmaceutical Sciences. 2006, 30(9): 413-416.(Corresponding author)

59. WANG Yan-qun; LI Yun-man; WANG Yan-hui; GONG Hai-tao.Protective Effects of "Xiongge Naotong Tablet" on Rats with Middle Cerebral Artery Occlusion [J]. Shanghai Journal of Traditional Chinese Medicine. 2006, 40(10): 60-62.

60. SUN Shi-xue; LI Yun-man.Review on effects of NO on rheumatoid arthritis and related drugs [J].Pharmaceutical and Clinical Research. 2007, 15(3): 175-78. (Corresponding author)

61. GUAN Teng; LI Yun-man; SUN Hong-bin. Effects of maslinic acid as a novel glycogen phosphorylase inhibitor on cerebral ischemia in mice [J].Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(4): 381-384. (Corresponding author)

62. ZHU Jun-rong; ZHU Yu-bing; XIAO Da-wei; FAN Wei-rong; LI Yun-man. Effects of borneol on the pharmacokinetics of scutellarin in rats [J].Chinese Journal of New Drugs. 2007, 16(22). (Corresponding author)

63. ZHU Jun-rong; LI Yun-man; FANG Wei-rong; LIU Shi-xu. Protective effects of scutellarin and borneolum injection on experimental cerebral ischemia in animals. Journal of China Pharmaceutical University. 2007: 456-460. (Corresponding author)

64. TANG Xu-Zhen, GUAN Teng, QIAN Yi-Song, LI-Yun-Man, SUN Hong-Bin, HUANG Jing-Hui, ZHANG YU. Effect of Maslinic Acid as a Novel Glycogen Phosphorylase Inhibitor on Blood Glucose and Hepatic Glycogen in Mace. Chinese Journal of Natural Medicines. 2008, 6(1): 53-56. (Corresponding author)

65. GONG Xiao-Jian; RONG Zhi-Tao; ZHANG Le-Duo; JIANG Feng-Rong; LI Yun-Man; LIU Guo-Qing. Antagonism Effect of Ginkgolides on Vascular Dementia. Chinese Journal of Natural Medicines. 2008, 6(3): 227-231 (Corresponding author)

66. QIAN Yi-song GUAN Teng TANG Xu-zhen LI Yun-man. Astrocytes and cerebral ischemic injury.Chinese Journal of New Drugs. 2008, 17(11): 897-904. (Corresponding author)

67. FANG Fang; LI Yun-man; FANG Wei-rong; DENG Yan.The effects of ginkgolide B on contraction of isolated rat thoracic aorta.Pharmaceutical and Clinical Research. 2008, 16(4). (Corresponding author)

69. LIU Shi-xu; LI Yun-man; FANG Wei-rongDepartment. Protective effect of sodium tanshinone B on focal cerebral ischemia-reperfusion injury in rats.Journal of China Pharmaceutical University. 2008, 39(4): 338-342. (Corresponding author)

Books:

1. Yunman Li (editor), Weirong Fang. Caodiovascular Pharmacology. Science and Technology Press of Jiangsu. 2014.3. 1st edition.

2. Yijia Lou, Yunman Li (associate editor). Drug Toxicology. Peoples Medicinal Publishing House. Beijing. 2011.7.

3. Qilong Ding, Yunman Li ( editor). Experiment and Guide for Physiology. Beijing: China Medicine Tecnology Press. 2004.3

4. Chart 35: Molecular base of Nervous System Drugs. Current Pharmacology. Peking Union Medical College Press. 2008.5, 2nd edition.

5. Associate editor. Human Anatomy and Physiology. China Medical Science and Technology press. 2009.8. 1st edition.




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