WANG, XIAOSHENG

Release date:2016-05-18  Release:





WANG, XIAOSHENG

Associate Professor of Bioinformatics

Deputy Director of Medical and Biological Informatics

School of Basic Medicine and Clinic Pharmacy

Email: xiaosheng.wang@cpu.edu.cn


Research Summary

Professor WANG’s research focuses on development of algorithms for analysis of genomics data including next-generation sequencing, microarray data etc., discovery of drug targets for cancer therapy by the bioinformatics approach, systems and computational biology for elucidating the nature of oncogenesis, and inference of molecular interaction networks relevant to specific disease. Particularly, he is interested in first predicting potential biomarkers for cancer diagnosis and treatment by integrating different types of "omics" data using the bioinformatics approach, and then performing experiments to screen valuable biomarkers for clinical application.  


Education

2010     Ph.D., Computational Biology, Kyoto University

Academic Experience

2015-   Associate Professor of Bioinformatics, China Pharmaceutical University

2013-2015   Instructor of Bioinformatics, University of Nebraska Medical Center

2010-2013   Postdoctoral Researcher of Bioinformatics, National Cancer Institute  

Awards and Honors

2010      Research Fellowship, American National Cancer Institute

2007       Ph.D. Scholarship, Japanese Government

Publications

  1. Xiaosheng Wang, Chittibabu Guda. Integrative Exploration of Genomic Profiles for Triple Negative Breast Cancer Identifies Potential Drug Targets. Medicine, accepted.

  2. Suleyman Vural, Xiaosheng Wang, Chittibabu Guda. Classification of breast cancer patients using somatic mutation profiles and machine learning approaches. BMC Systems Biology, in press.

  3. Xiaosheng Wang, Yue Zhang, Ze-Guang, Kun-Yan He.Malignancy of Cancers and Synthetic Lethal Interactions Associated with Mutations of Cancer Driver Genes. Medicine2016, 95(8): e2697.

  4. You Li, Xiaosheng Wang, Suleyman Vural, Nitish Mishra, Kenneth H. Cowan, Chittibabu Guda. Exome analysis reveals differentially mutated gene signatures of stage, grade, and subtype in breast cancers. PLoS ONE 2015, 10(3): e0119383.

  5. Ru Shen, Xiaosheng Wang, Chittibabu Guda. Discovering Distinct Functional Modules from Cancer Protein-protein Interaction Networks. Biomed Research International 2015, http://dx.doi.org/10.1155/2015/146365.

  6. Nalin C. W. Goonesekere, Xiaosheng Wang, Lindsey Ludwig, Chittibabu Guda. A Meta Analysis of Pancreatic Microarray Datasets Yields New Targets as Cancer Genes and Biomarkers. PLoS ONE 2014, 9(4): e93046.

  7. Xiaosheng Wang, Chittibabu Guda. Computational analysis of transcriptional circuitries in human embryonic stem cells reveals multiple and independent networks. Biomed Research International 2014, 2014(1):103-113.

  8. Xiaosheng Wang. Identification of Marker genes for Cancer Based on Microarrays Using a Computational Biology Approach. Current Bioinformatics 2014, 9(2):140-146.

  9. Xiaosheng Wang, Richard Simon. Identification of potential synthetic lethal genes to p53 using a computational biology approach. BMC Medical Genomics 2013, 6:30.

  10. Xiaosheng Wang. Discovering molecular associations between ageing, stem cell, and cancer based on gene expression profiling. Chinese Journal of Cancer 2013, doi: 10.5732/cjc.012.10114.

  11. Xiaosheng Wang. Robust Two-gene Classifiers for Cancer Prediction. Genomics 2012, 99(2): 90-95.

  12. Xiaosheng Wang. Computational Analysis of Expression of Human Embryonic Stem Cell-associated Signatures in Tumors. BMC Research Notes 2011, 4:471.

  13. Xiaosheng Wang, Richard Simon. Microarray-based Cancer Prediction Using Single Genes. BMC Bioinformatics 2011, 12:391.

  14. Xiaosheng Wang, Osamu Gotoh. Accurate Molecular Classification of Cancer Using Simple Rules. BMC Medical Genomics 2009, 2:64.