Release date:2016-05-18  Release:



Associate Professor of Clinical Pharmacy

School of Preclinical Medicine and Clinical Pharmacy

Email: mingxu@cpu.edu.cn

Research Summary

Our research interests focus on rational drug use and clinical drug evaluation, as well as cardiovascular pharmacology. Until now25SCI papers have been published, and 15 papers of them were published as the first author. 17 conference papers were published in the FASEB Journal and Hypertensionjournalin international academic conferences. At present, our lab issupported by the fund of high-level talent introduction in China Pharmaceutical University(1050010016), the National Natural Science Foundation of China (81570413) and the Central College Fundamental Research (2016PT053). Participated inwriting the eighth edition of the National Pharmacy Textbook "Overview of pharmacy services".  


2006   Ph.D., Pharmacology, China Pharmaceutical University

2003   M.S., PharmacologyAnhui Medical University

Academic Experience

2014- Associate Professor of China Pharmaceutical University  

2009-2014  Postdoctor of Virginia Commonwealth University

Awards and Honors

2014 Excellent postdoctoral in Virginia Commonwealth University



1Xu M, Zhang Q, Li PL, Nguyen T, Li X, Zhang Y. Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs.Front Biosci (Landmark Ed). 2016 Jan 1; 21:696-706.

2Xu M, Li XX, Wang L, Wang M, Zhang Y, Li PL.Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene. Cell Physiol Biochem. 2015;37(2):432-44. doi: 10.1159/000430366. Epub 2015 Aug 28.

3Xu M, Hu C, Khan HH, Shi FH, Cong XD, Li Q, Dai Y, Dai DZ.Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43.Acta Pharmacol Sin. 2016 Feb;37(2):246-54. doi: 10.1038/aps.2015.125. Epub 2016 Jan 18.

4Xu M, Li XX, Chen Y, Pitzer AL, Zhang Y, Li PL. Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes.J Cell Mol Med. 2014;18(11):2165-75.

5Xia M, Boini KM, Abais JM, Xu M, Zhang Y, Li PL.Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin. Am J Pathol. 2014; 184(5):1617-28.

6Li X, Xu M, Pitzer AL, Xia M, Boini KM, Li PL, Zhang Y.Control of autophagy maturation by acid sphingomyelinase in mouse coronary arterial smooth muscle cells: protective role in atherosclerosis.J Mol Med (Berl). 2014; 92(5):473-85.

7Zhang Y, Xu M, Xia M, Li X, Boini KM, Wang M, Gulbins E, Ratz PH, Li PL.Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovasc Res. 2014; 102(1):68-78.

8Xiong J, Xia M, Xu M, Zhang Y, Abais JM, Li G, Riebling CR, Ritter JK, Boini KM, Li PL.Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes.J Cell Mol Med. 2013;17(12):1598-607.

9Xu M, Li XX, Xiong J, Xia M, Gulbins E, Zhang Y, Li PL.Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes.Biochim Biophys Acta. 2013; 1833(12):3228-36.

10Xu M, Li XX, Ritter JK, Abais JM, Zhang Y, Li PL.Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes.PLoS One. 2013 Aug 7; 8(8):e71212.

11Wei YM, Li X, Xu M, Abais JM, Chen Y, Riebling CR, Boini KM, Li PL, Zhang Y.Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes.Cell Physiol Biochem. 2013; 31(6):925-37.

12Xu M, Li X, Walsh SW, Zhang Y, Abais JM, Boini KM, Li PL.Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes.Am J Physiol Cell Physiol. 2013;304(5):C458-66.

13Boini KM, Xia M, Abais JM, Xu M, Li CX, Li PL.Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-β-synthase.PLoS One. 2012; 7(9):e45020.

14Xu M, Xia M, Li XX, Han WQ, Boini KM, Zhang F, Zhang Y, Ritter JK, Li PL.Requirement of translocated lysosomal V1 H(+)-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells.Mol Biol Cell. 2012; 23(8):1546-57.

15Han WQ, Xia M, Xu M, Boini KM, Ritter JK, Li NJ, Li PL.Lysosome fusion to the cell membrane is mediated by the dysferlin C2A domain in coronary arterial endothelial cells.J Cell Sci. 2012; 125(Pt 5):1225-34.

16Xu M, Zhang Y, Xia M, Li XX, Ritter JK, Zhang F, Li PL.NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice. Free Radic Biol Med. 2012 ;52(2):357-65.

17Han WQ, Xia M, Zhang C, Zhang F, Xu M, Li NJ, Li PL.SNARE-mediated rapid lysosome fusion in membrane raft clustering and dysfunction of bovine coronary arterial endothelium.Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2028-37.

18Zhang F, Xu M, Han WQ, Li PL.Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells. Am J Physiol Cell Physiol. 2011; 301(2):C421-30.

19Xu M, Tang YQ, Dai DZ, Zheng YF, Cheng YS, Zhang Q, Dai Y. Comparison of sildenafil with strontium fructose diphosphate in improving erectile dysfunction against upregulated cavernosal NADPH oxidase, protein kinase Cå, and endothelin system in diabetic rats. J Pharm Pharmacol. 2012; 64(2):244-51. (IF=2.033)

21Xu M, Dai DZ, Zhang Q, Cheng YS, Dai Y. Upregulated NADPH oxidase contributes to diabetic testicular complication and is relieved by strontium fructose 1,6-diphosphate. Exp Clin Endocrinol Diabetes. 2010; 118(7):459-65. (IF=1.826)

22Xu M, Ji H, Dai DZ, Tang XY, Dai Y. Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats. J Pharm Pharmacol. 2008; 60(6):739-45. (IF=1.847)

23Xu M, Dai DZ, Dai Y. Normalizing NADPH Oxidase Contributes to Attenuating Diabetic Nephropathy by a Dual Endothelin Receptor Antagonist CPU0213 in Rats. Am J Nephrol. 2008; 29(3):252-6. (IF=3.481)

24Xu M, Hu XP, Zhu H, Wu YY, Kuang LX, Yang Y. Immunomodulatory effects of total astragalus extract (in Chinese). Pharmacology and Clinics of Chinese Materia Medica. 2005; 21(3):27-9.

25Xu M, Zhu H, Wu YY, Zhou YH, Yang YY, Yang Y. The inhibitory effect of total astragalus extract on HSC-T6 cell proliferation and collagen synthesization induced by oxidative stress (in Chinese). Pharmacology and Clinics of Chinese Materia Medica. 2006; 22(3, 4):60-3.

26Xu M, Wang YM, Liang JY, Kuang LX, Yang Y. Effects of chitosan-bismuth on rat gastric ulcer models (in Chinese). Anhui Medical and Pharmaceutical Journal. 2006; 10(5):328-9.

27Jin Y, Xu Y, Xu M, Xue S. Increased risk of cancer among relatives of patients with lung cancer in China. BMC Cancer. 2005; 11(5):146.

28Jin Y, Xu Y, Xue S, Liu H, Zhao J, Xu M.Predicting the development of early skin test sensitization in offspring of parents with asthma.Eur J Clin Invest. 2007 Jun;37(6):522-7.

Abastrat in meeting

  1. Li XX, Ashley Pitzer, Li PL, and Zhang Y. Regulation of TRPML1-mediated Dynein Activation and Autophagosome Trafficking by Acid Sphingomyelinase in Coronary Arterial Smooth Muscle Cells. FASEB J April 2015 29:782.10

  2. Xu M, Li XX, Wang M, Zhang Y, Li PL.Contribution of nuclear factor E2-related factor 2 to the atherogenic phenotype transition in coronary arterial smooth muscle cells lacking CD38 gene. FASEB J. 28:1065.16, 2014

  3. Xu M, Li XX, Chen Y, Zhang Y, Li PL. Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes. FASEB J. 28:1077.10, 2014

  4. Xu M, Li XX, Zhang Y, Li PL. Dynein-mediated Lysosome Trafficking in Autophagic Flux of Mouse Coronary Arterial Myocytes. FASEB J. 27: 1092.6, 2013.

  5. Xu M, Li XX, Zhang Y, Li PL. TRP-ML1 channels-Mediated Ca2+ Release Contributes to FasL-Induced Lysosomal Trafficking and Interactions with the Sarcoplasmic Reticulum in Coronary Arterial Myocytes. FASEB J. 27: 876.3, 2013.

  6. Xu M, Zhang F, Xia M, Li XX, Abais JM, Boini KM, Li PL. Lysosomal regulation of autophagy efflux via CD38-mediated signaling in mouse coronary arterial myocytes. Hypertension 58(5):E178, 2011.

  7. Xu M, Zhang F, Li XX, Li PL. Contribution of TRP-MLs Channels to a two-phase Ca2+ release response to fas activation in mouse coronary arterial myocytes. Hypertension, 58(5):E90, 2011.

  8. Xu M, Zhang F, Xia M, Li PL. Cyclic ADP-ribose-mediated regulation of intra- and extracellular O2.- production via NADPH oxidase in coronary arterial myocytes: Evidence from CD38 gene KO mice. Hypertension 56(5):E147-E148, 2010.

  9. Xu M, Xia M, Zhang F, Li PL. Translocation and activation of lysosomal H+-ATPase in the formation of membrane raft redox signalosomes in coronary endothelial cells. Hypertension 56(5):E149, 2010.

  10. Zhang Y, Xu M, Xia M, Li X, Boini K, Li PL. Failure of autophagy maturation in CD38 deficient coronary arterial myocytes due to inhibition of dynein-mediated autophagosome trafficking. FASEB J. 28:865.3. 2014

  11. Wang M, Xu M, Chen Y, Xia M, Zhang Y, Li PL. Implication of CD38/NAADP-regulated autophagic flux in the phenotypic plasticity of mouse coronary arterial myocytes. FASEB J .28:849.32014.

  12. Chen Y, Ashley Pitzer, Li X, Xu M, Zhang Y, Li PL. High mobility group box protein 1 as a novel vascular permeability factor derived from endothelial inflammasome activation during obesity (688.5) FASEB J. 28:688.5, 2014.

  13. Zhang Y, Xu M, Li X, Li XX, Xia M, Xiong J, Boini K, Li PL. Control of Lysosome Trafficking and Autophagic Flux by Acid Sphingomyelinase in Coronary Arterial Myocytes: Protective Role in Atherosclerosis. Hypertension. 60:A513, 2012

  14. Wei YM, Zhang Y, Li XX, Xu M, Li PL. Enhancement of autophagy by simvastatin through inhibition of rac1-mTOR signaling pathway. FASEB J. 26: 681.3, 2012.

  15. Xiong J, Xia M, Xu M, Li XX, Abais JM, Boini KM, Li PL. Autophagy maturation controlled by CD38-lysosome signaling in glomerular podocytes of mice. FASEB J. 26: 690.14, 2012.

  16. Xia M, Boini KM, Abais JM, Li XX , Xu M, Li PL. NALP3 inflammasome activation in the coronary arterial wall of obese mice. FASEB J. 26: 877.7, 2012.

  17. Zhang F, Xu M, Boini KM, Xia M, Li PL. Enhanced lipid deposition and foam cell formation in coronary artery wall by deletion of CD38 gene. Hypertension 56(5):E57, 2010.