Release date:2016-05-18  Release:


Associate Professor of Department of Physiology  cardiovascular pharmacology. School of College of basic medicine and clinical pharmacy

Phone: 86-25-83271341

Email: yth0001@126.com

Research Summary

Associate professor YAN was born in August 1969 in Wenling, Zhejiang Province. The main research direction of him is cardiovascular pharmacology, especially cardiovascular and cerebrovascular disease (such as coronary heart disease and cerebral apoplexy) and diabetes, which provide new methodsfor the research and development of new drugs. Heis engaged in cardiovascular pharmacology and new drug evaluation for many years. He commitmentshis energy to theoretical teaching for Human Anatomy and Physiology, Cardiovascular Pharmacology and Modern Pharmacology, as well as the experimental teaching for undergraduate students. Collectively, Associate professor YAN is a excellent teacher with a sense of responsibility.


2008       Ph.D., PharmacologyChina Pharmaceutical University

1998       M.S., PharmacologySecond Military Medical University

1991       B.S., PharmacologyChina Pharmaceutical University

Academic Experience

2006- now  Associate professor of pharmacology, Department of Physiology of China Pharmaceutical University

2005-2006  Lecturer of pharmacologyDepartment of Physiology of China Pharmaceutical University

1998-2004  Department Director of pharmacology, Department of Second Military Medical University

1991-1995  Teaching assistant of pharmacology,  Department of Nanjing Naval Medical College

Awards and Honors

2006       First Prize, for Teaching Competition of Young TeachersCollege of Pharmacy of China Pharmaceutical University


2012; Human Anatomy and Physiology, Southeast University Press

Papers and Articles

1 Jiang W, Luo F, Lu Q, Liu J, Li P, Wang X, Fu Y, Hao K, Yan T*, Ding X. The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state [J]. Chem Biol Interact. 2016; 5; 243: 127-134              

2 Gao J, Zhou RYou XLuo FHe HChang XZhu LDing XYan T*. Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer's disease via SIRT1/NF-κB pathway [J]. Metab Brain Dis. 2016 Feb 24    

3 Zhu L, Chen T, Chang X, Zhou R, Luo F, Liu J, Zhang K, Wang Y, Yang Y, Long H, Liu Y, Yan T*, Ma C. Salidroside ameliorates arthritis-induced brain cognition deficits by regulating Rho/ROCK/NF-κB pathway [J]. Neuropharmacology. 2016; 103:134-142                                         

4 Chen TMa ZZhu LJiang WWei TZhou RLuo FZhang KFu QMa CYan T*. Suppressing Receptor-Interacting Protein 140: a New Sight for Salidroside to Treat Cerebral Ischemia [J]. Mol Neurobiol. 2015 Nov 13

5 Xiayun Chang, He He, Lingpeng Zhu, Jin Gao, Tingting Wei, Zhanqian Ma, Tianhua Yan*.Protective effect of apigenin on Freund’s complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway [J]. Chemico-Biological Interactions. 2015; 236: 41–46     

6 Jin Gao, He He, Wenjiao Jiang, Xiayun Chang, Lingpeng Zhu, Fen Luo, Rui Zhou, Chunhua Ma, Tianhua Yan*. Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer’s disease [J]. Behavioural Brain Research. 2015; 293: 27–33                             7 Lingpeng Zhu, Tingting Wei, Jing Gao, Xiayun Chang, He He,Mingxing Miao, Tianhua Yan*. Salidroside attenuates lipopolysaccharide (LPS) induced serum cytokines and depressive-like behavior in mice [J]. Neuroscience Letters. 2015; 606: 1–6                                                 8 Xiayun Chang, Fen Luo, Wenjiao Jiang , Lingpeng Zhu, Jin Gao , He He , Tingting Wei, Shilin Gong, Tianhua Yan*. Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro [J]. International Immunopharmacology. 2015; 28: 604–615    

9 He He, Xiayun Chang, Jin Gao, Lingpeng Zhu, Mingxing Miao, Tianhua Yan* . Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3β Signaling [J].Inflammation. 2015. DOI: 10.1007/s10753-015-0200-7                                         

10 Chen T, Xiao L, Zhu L, Ma S, Yan T *, Ji H*. Anti-Asthmatic Effects ofGinsenoside  Rb1 in a Mouse Model of Allergic Asthma Through Relegating Th1/Th2 [J]. Inflammation. 2015; 38(5):1814-1822

11 Ma C, Zhu L, Wang J, He H, Chang X, Gao J, Shumin W, Yan T*. Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway [J]. Journal of Ethnopharmacology. 2015; 20; 168: 349-355                                         12 Chen T, Gao J, Xiang P, Chen Y, Ji J, Xie P, Wu H, Xiao W, Wei Y, Wang S, Lan L, Ji H, Yan T*. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance [J]. Int Immunopharmacol. 2015; 26(2): 338-348                                       

13 Zhu L, Wei T, Gao J, Chang X, He H, Luo F, Zhou R, Ma C, Liu Y, Yan T*. The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation [J]. Apoptosis. 2015; 20(11): 1433-1443                                           14 Chen T, Guo Q, Wang H, Zhang H, Wang C, Zhang P, Meng S, Li Y, Ji H, Yan T*. Effects of esculetin on lipopolysaccharide (LPS)-induced acute lung injury via regulation of RhoA/Rho Kinase/NF-кB pathways in vivo and in vitro [J]. Free Radic Res. 2015; 49(12): 1459-1468                 

15 Zhang L, Yan L, Jiang J, Wang Y, Jiang Y, Yan T*, Cao Y*. The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans [J]. Virulence. 2014; 5(6): 655-664

16 Wang J, Xiao L, Zhu L, Hu M, Wang Q, Yan T*.The Effect of Synthetic Salidroside on Cytokines and Airway Inflammation of Asthma Induced by Diisocyanate (TDI) in Mice by Regulating GATA3/T-bet[J]. Inflammation. 2014 Jul

17 Wang J , Liu YT, Xiao L, Zhu L, Wang Q, Yan T*. Anti-Inflammatory Effects of Apigenin in Lipopolysaccharide-Induced Inflammatory in Acute Lung Injury by Suppressing COX-2 and NF-kB Pathway [J]. Inflammation. 2014 Jun 24

18 Yan T, Fu Q, Wang J, Ma S. UPLC-MS/MS determination of ephedrine, methyl ephedrine, amygdalin and glycyrrhizic acid in Beagle plasma and its application to a pharmacokinetic study after oraladministration of Ma Huang Tang [J]. Drug Test Anal. 2014 May 13. doi: 10.1002/dta.1635

19 Yu S, Chai X, Wang Y, Cao Y, Zhang J, Wu Q, Zhang D, Jiang Y, Yan T*, Sun Q*. Triazole derivatives with improved in vitro antifungal activity over azole drugs [J]. Drug Des Devel Ther. 2014; 10(8):383-390

20 Jiang J, Zhao L, Yan L, Zhang L, Cao Y, Wang Y, Jiang Y, Yan T*, Cao Y*. Structural features and mechanism of translocation of non-LTR retrotransposons in Candida albicans [J]. Virulence. 2014; 5(2):245-252

21 Yao J, Hu R, Sun J, Lin B, Zhao L, Sha Y, Zhu B, You QD, Yan T*, Guo QL*. Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling [J]. Mol Carcinog. 2014; 53(2):145-15822 Wang H, Mei ZL, Zhong KL, Hu M, Long Y, Miao MX, Li N, Yan TH*, Hong H*. Pretreatment with antiasthmatic drug ibudilast ameliorates Aβ1-42-induced memory impairment and neurotoxicity in mice [J]. Pharmacol Biochem Behav. 2014; 124:373-379  doi: 10.1016/j.pbb.2014.07.006      

23 Zhu L, Wang J ,Wei T, He H , Gao J, Chang X, Yan T*. Effects of naringenin on inflammation in complete Freund's adjuvant-induced arthritis by regulating Bax/Bcl-2 balance [J]. Inflammation.2015. Feb;38(1):245-251.

24 Yan T, Wang J, Zhu L, Yan T*. Apigenin attenuates heart injury in

lipopolysaccharide-induced endotoxemia rat model by suppressing sphingosine kinase1/sphingosine1-phosphate signaling pathway [J]. PLOS ONE. 2014

25 Qing Shan Liu, Ke Qin Li, Jun Li, Xiao Ying Yin, Tian Hua Yan*. A Novel Method for Prepairing higher performance Picroside I Surface Molecularly Imprinted Polymers for TCM Research. Advanced Materials Research September. 2013, 642-645.