ZHANG, GUANGQIN

Release date:2016-05-18  Release:





ZHANG, GUANGQIN

Associate Professor of Clinical Pharmacy

School of Preclinical Medicine and Clinical Pharmacy

Phone: 86-25-83271070

Email: zhanggq@cpu.edu.cn

Research Summary

Associate professor ZHANG’s research focuses on the study of ion channels in myocytes and neurons by using patch clamp technique, calcium signal transduction under physiological and pathological conditions by using laser scanning confocal microscope and molecular biology techniques, and Clinical adverse drug reactions and rational drug use.

Education

2001       Ph.D., Pharmacology, China Pharmaceutical University

1992       M.S.,  PharmacologyChina Pharmaceutical University

1985       B.S.,   PharmacyKaifeng Medical College

Academic Experience

2004-      Associate Professor of Clinical Pharmacy, China Pharmaceutical University

2009-2010  Research Scientist ofCardiovascular, National Heart Centre Singapore

2005-2006Postdoctoral of Biochemistry,The Hong Kong University of Science & Technology

2001-2003 Postdoctoral of Biophysics, Peking University

1995-2003 Lecturer of Pharmacology, China Pharmaceutical University.

1992-1995 Assistant Lecturer of Pharmacology, China Pharmaceutical University

Publications

  1. Zhao Y, Wei H, Kong G, Shim W, Zhang G.Hydrogen sulfide augments the proliferation and survival of human induced pluripotent stem cell-derived mesenchymal stromal cells through inhibition of BKCa.Cytotherapy. 2013 ;15(11):1395-405.

  2. Zhang GQ, Wei H, Lu J, Wong P, Shim W. Identification and characterization of calcium sparks in cardiomyocytes derived from human induced pluripotent stem cells. PLoS One. 2013;8(2):e55266.

  3. Wei H, Zhang G, Qiu S, Lu J, Sheng J, Manasi, Tan G, Wong P, Gan SU, Shim W.Hydrogen sulfide suppresses outward rectifier potassium currents in human pluripotent stem cell-derived cardiomyocytes. PLoS One. 2012;7(11):e50641.

  4. Ma D, Wei H, Lu J, Ho S, Zhang G, Sun X, Oh Y, Tan SH, Ng ML, Shim W, Wong P, Liew R.Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J. 201334(15):1122-33..

  5. Shim W, Mehta A, Lim SY, Zhang G, Lim CH, Chua T, Wong P.G-CSF for stem cell therapy in acute myocardial infarction: friend or foe? Cardiovasc Res. 2011;89(1):20-30.

  6. Zhang GQ, Qiu SH, Wei HM.Scutellarinblockssodiumcurrent in freshlyisolatedmouse hippocampal CA1 neurons. Neurochem Res. 2011, 36:947-54.

  7. Zhang GQ, Wang H, Liu WT, Dong H, Fong WF, Tang LM, Xiong YH, Yu ZL, Ko KM.Long-Term Treatment with a Chinese Herbal Formula, Sheng-Mai-San, Improves Cardiac Contractile Function in Aged Rats: The Role of Ca2+ Homeostasis.Rejuvenation Res. 2008, 11: 991-1000.

  8. Zhang GQ, Huang XD, Wang H, Leung AK, Chan CL, Fong DW, Yu ZL. Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips.J Ethnopharmacol. 2008;118:290-4.

  9. Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ. Temperature dependence and thermodynamic properties of Ca2+ sparks in rat cardiomyocytes.  Biophys J. 2005;89:2533-41

  10. Zhang Guangqin, Fu Yu, Yang Dongmei, Hao Xuemei, Bai Shuhua, Tang Yiqun, Edward G Lakatta, Cheng Heping. Contribution of Spontaneous L-type Ca2+ channel activation to the genesis of Ca2+ sparks in resting cardiac myocyte. Science in China (C) 2004;47(1):31-8

  11. ZHANG Guang-Qin, HAO Xue-Mei, DAI De-Zai, FU Yu, ZHOU Pei-Ai, WU Cai-Hong. Puerarin blocks Na+ current in isolated rat ventricular myocytes. Acta Pharmacol Sin 2003; 24(12): 1212-6

  12. ZHANG Guang-Qin, HAO Xue-Mei, CHEN Shi-Zhong, ZHOU Pei-Ai, CHENG He-Ping, WU Cai-Hong. Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons. Acta Pharmacol Sin. 2003; 24(12):1248.-52

  13. G-Q Zhang, X-M Hao, P-A Zhou, C-H Wu. Effect of paeonol on L-type calcium channel in rat ventricular myocytes. Mothods Find Exp Clin Pharmacol 2003; 25(4):281-5

  14. ZHANG Guang-Qin, HAO Xue-Mei, ZHOU Pei-Ai, WU Cai-Hong, DAI De-Zai.Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. Acta Pharmacol Sin 2001; 22(3):253-6.

  15. Zou L.Y., Hao X.M., Zhang G.Q., Zhang M., Guo J.H., Liu T.F.: Effect of Tetramethyl Pyrazine on L-type Calcium Channel in Rat Ventricular Myocytes. Can. J. Physiol. Pharmacol 2001; 79: 621-6.