ZHAO, LI

Release date:2016-05-18  Release:

 

ZHAO, LI

Associate Professor of Pharmacology

School ofBasic Medicine and Clinical Pharmacology

Phone: 86-25-8618XXXX

Email:zhaoli@cpu.edu.cn

 

Research Summary

Zhao Li, associate professor of pharmacology, doctorial tutor, member of Chinese Pharmacological Society. She focuses on oncology, especially for the mechanism of oncological etiology and drug intervention, reversion of resistance to anti-cancer agent, combination therapy and induction of apoptosis of cancer cells. Doctor Zhao hosted the National Natural Science Foundation of China twice, once forScience Foundation for Distinguished Young Scholars of Jiangsu Province and the Fundamental Research Funds for the Central Universities from Ministry of Education twice. She gained key project of innovative drug invention and development of National Ministry of Technology twice, the key project of the twelfth five-year plan four times and numerous innovative drug research project co-operated with pharmaceutical enterprise. Doctor Zhao has been awarded with Teaching Achievement of China Pharmaceutical University twice. She has the honor of the Eminent Youth Teacher of Jiangsu Qinglan Project and the Lead Youth Scholar of Jiangsu Province. There were more than 40 research papers published.

Education

2011   Ph.D.,Pharmacology,China Pharmaceutical University

2004   M.S., Pharmacology,China Pharmaceutical University

2000   B.S.,Bio-pharmaceutics,China Pharmaceutical         University

Academic Experience

2015 till now  Associate Professor of Pharmacology, SchoolofBasic Medicine and Clinical Pharmacology

2014-2015Visiting ScholarMedical School of University of   Florida

2012-2014  Associate Professor of Pharmacology, School of Pharmacy

Awards and Honors

2015First price of Natural Science Award forthe Discovery, Optimization,and Mechanism of Natural Anti-cancer Product with Cage Structure, National Ministry of Education

2009       The second price, Teaching Achievement of China Pharmaceutical University forThe Practice of Oncology in High Level Pharmacological Talents,China Pharmaceutical University

2013       The third price, Teaching Achievement of China Pharmacological University forThe Development of the Stereoscopic Teaching Structure of HUMAN ANOTOMY AND PATHOLOGY,China Pharmaceutical University

2014       The Eminent Youth Teacher of Jiangsu Qinglan Project, Education Department of Jiangsu Province

2016       The Lead Youth Scholar of Jiangsu Qinglan Project, Education Department of Jiangsu Province

 

2010       The Study of Reverse Effect and Mechanism of Oroxylin A on Cell Adhesion Mediated-drug Resistance (CAM-DR) of Hepatocellular Carcinoma, the National Natural Science Foundation of China

2011       The Study of the Reverse Effect of Wogonin on Cancer Cells Based on Intergrinβ1the Fundamental Research Funds for the Central Universities

2013      The Study of Soluble Factor Mediated Drug Resistance in Leukemia, the Fundamental Research Funds for the Central Universities

2014     The Study of Reverse Effect of Oroxylin A on CML Resistance to Imatinib Based on SDF-1α/CXCR4 Axis, the National Natural Science Foundation of China

2015     The Study of Reverse Effect and Mechanism of Natural Product on Drug Resistance Based on Soluble Factor SDF-1αScience Foundation for Distinguished Young Scholars of Jiangsu Province

Publications (Recent 3 years)

  1. Xiaoping Wang,Yang Sun,Yue Zhao,Youxiang Ding, XiaoboZhang, Lingyi Kong,Zhiyu Li,Qinglong Guo*,Li Zhao*., Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation.,Biochemical Pharmacology, 2016,70-81IF 5.009)

  2. Xuefen Xu,Xiaobo Zhang, Yicheng Liu, Lin Yang,Shaoliang Huang,LuLu,Shuhao Wang,Qinglong Guo*,Li Zhao*., BM microenvironmental protection of CML cells from imatinib through Stat5/ NF-κBsignaling andreversal by Wogonin.,oncotarget, 2016accepted, IF 6.35)

  3. Li Zhao#, Han-Chi Miao#, Wen-Jun Li, Yang Sun, Zhi-Yu Li, Qing-Long Guo LW-213 induces G2/M cell cycle arrest through Akt/Gsk3β/β-catenin signaling pathway in human breast cancer cellsMolecular carcinogenesis2016;55(5):778-92IF4.808

  4. Li Zhao#, Wei Li#, Yuxin Zhou, Yi Zhang, Shaoliang Huang, Zhiyu Li, Qinglong Guo.,The overexpression and nuclear translocation of Trx-1 during hypoxia confers HepG2 cellsresistance to DDP and GL-V9 reverses the resistance by suppressing Trx-1/Ref-1 axis.Free Radical Biology and Medicine2015;82:29-41. IF5.736

  5. Jing Yao#, Li Zhao#,Qing Zhao,Yue Zhao,Yang Sun, Yi Zhang, Hanchi Miao,Qi-Dong You, Rong Hu, Qing-Long GuoNF-κB and Nrf2signaling pathways contribute to wogonin-mediatedinhibition on inflammation-associated colorectal carcinogenesisCell Death & Disease, 2014, 5;5:e1283.(IF 5.177

  6. Xin LiHan-chi MiaoYi ZhangWei LiZhiyu LiYu-xin ZhouLi Zhao*Qing-Long Guo*

Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway.ArchivesofToxicology, 2015, 89(1), 121-136IF5.98

  1. Yu Wang, Hanchi Miao, Wei Li, Jing Yao, Yang Sun, Zhiyu Li,Li Zhao*, Qinglong Guo*., CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells. Biochemical Pharmacology,2014,  212-225IF 5.009)

  2. Xuefen XuYi ZhangWei Li, Hanchi Miao, Haiwei Zhang, Yuxin Zhou, Zhiyu Li, Qidong You,Li Zhao*, Qinglong Guo*Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathwayBiochemical Pharmacology,2014;92,220-234(IF 5.009)

  3. Di Pan, Wei Li, Hanchi Miao, Jing Yao, Zhiyu Li, Libin Wei,Li Zhao* , Qinglong Guo*. LW-214, a newly synthesized flavonoid, induces intrinsic apoptosis pathway by down-regulatingTrx-1in MCF-7 human breast cells.Biochemical Pharmacology,2014; 87(4), 598–610 (IF 5.009)

  4. YiZhang#,LiZhao#,XinLi,Ya-JingWang,JingYao,HuWang, Fan-NiLi,Zhi-YuLi,Qing-LongGuo. V8,anewlysyntheticflavonoid, inducesapoptosis throughROS-mediatedER tresspathwayinhepatocellularcarcinoma.ArchivesofToxicology,2014;88(1):97-107.(IF5.98)

  5. Hu Wang#,Li Zhao#, Zhi-Yu Li, Qi-Dong You, Qing-Long Guo, Wogonin reverseshypoxiaresistance of humancolon cancerHCT116 cells viadown-regulation of HIF-1α andglycolysis,by inhibiting PI3K/AKTsignaling pathway.Molecular carcinogenesis 201453, 107–118(IF 4.808)