KOU, JUNPING

Release date:2016-05-18  Release:

KOU, JUNPING

Professor of Basic Discipline ofIntegrated Traditional Chinese and Western Medicine

Director of Department of Complex Prescription of Traditional Chinese Medicine

Vice Dean of School of Traditional Chinese Pharmacy

Phone: 86-25-86185241

Email: junpingkou@cpu.edu.cn

Research Summary

Professor KOU’s research focuses on theresearch of mechanism and effective material basisof Chinese traditional medicine. She is major in the mechanism of complex prescription of TCM and target identification of effective components of Chinese herbs. Meanwhile, she also studies the function of vascular endothelium and pathology of vascular diseases.  


Education

2005     Ph.D., Physiology,Nanjing University

2000     M.S., Chinese Materia Medica,

China Pharmaceutical University

1994     B.S.,  Pharmacology of Chinese Materia Medica,

China Pharmaceutical University

Academic Experience

2014.6-2014.7  Visiting Scholar, School of Medicine of Yale University

2009-          Professor of Basic Discipline ofIntegrated Traditional Chinese and Western Medicine,   China Pharmaceutical University

2007.10-2008.10Visiting Scholar, Department of Pharmacology, Gifu Pharmaceutical University

2005.6-2009.6 Associate Professor of Basic Discipline ofIntegrated Traditional Chinese and Western Medicine, China Pharmaceutical University

2000.6-2005.6Assistant Professor, China Pharmaceutical University

1994.8-2000.5    Teaching Assistant, China Pharmaceutical University

Awards and Honors

2015: The Second Prize of the Reform of Postgraduates' Cultivation Mode , Jiangsu Ministry of Education


2013: The May Day Female Pace Setter, The union of Jiangsu Province Education, Science and Technology

2011: The Second Prize of Higher Scientific Research (Natural

Science) of the Ministry of Education (The second one),

Ministry of Education of the P. R. China

2010:The Fifth Session of ExcellentYoung Researcher (Integrated Medicine of Traditional Chinese and Western Medicine) in Jiangsu Province, Jiangsu Association of the Integrative Medicine

Publications

Books

Yan YQDou CGQi GRZhu DNYu BYKou JP (Associate Editor) . Introduction of Formulae with New Concept. 1st edition, Shanghai, 2005


Selected Papers

    1. Kou JP, Ni YLi N, Wang JR, Liu L, Jiang ZH. Analgesic and anti-inflammatory activities of total extract and individual fractions of Chinese medicinal ants Polyrhachis lamellidens. Biol Pharm Bull.2005, 28:176—180.

    2. Kou JP, Zhu DN, Yan YQ. Neuroprotective effects of the aqueous extract of Chinese medicine Danggui-Shaoyao -san on aged mice. J Ethnopharmacol. 2005, 97:313-318.

    3. Kou JP, Yu BY, Xu Q. Inhibitory effect of ethanol extract from Radix Ophiopogonis japonicus on venous thrombosis linked with its endothelium-protective and anti-adhesive activities. Vasc Pharmacol. 2005,43: 157 – 163.

    4. Kou JP, Tian YQ, Tang YK, Yan J, Yu BY. Antithrombotic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. Biol Pharm Bull. 2006, 29:1267-1270.

    5. Huang YL#, Kou JP#, Ma L, Song JX, Yu BY. Possible mechanism of the anti-inflammatory activity of Ruscogenin: Role of intercellular adhesion molecule-1 and nuclear factor-B. J Pharmacol Sci. 2008, 108:198-205.

    6. Zhou MH, Wang HG, Suolangjiba, Kou JP*, Yu BY*. Antinociceptive and anti-inflammatory activities of Aquilaria sinensis(Lour.)Gilg. Leaves extract. J Ethnopharmacol. 2008, 117:345-350.

    7. Jiang WW, Kou JP*, Zhang Z, Yu BY*. The effects of twelve representative avonoids on tissue factor expression in human monocytes: Structure-activity relationships. Thromb Res. 2009, 124: 714–720.

    8. Kou JP*, Chai CZ, Gao Z, Yu BY, Zhu DY, Yan YQ. Hypothesis on the principle of Danggui-Shao yao-San (DSS) for treating different diseases via the histamine H1 Receptor pathway. Modern Tradit Chin Med Mater Med, 2010, 12: 325–330

    9. Song JX#, Kou JP# (Co-author), Huang YL, Yu BY*. Ruscogenin mainly inhibits nuclear factor-κB but not Akt and mitogen-activated protein kinase signaling pathways in human umbilical vein endothelial cells. J Pharmacol Sci 2010,113: 409 – 413

    10. Liu Q, Kou JP**, Yu BY*. Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-B activation. Neurochem Int 2011, 58:119-125

    11. Ma ST, Kou JP*, Yu BY. Safety evaluation of steroidal saponin DT-13 isolated from the tuber of Liriope muscari (Decne.) Baily Food Chem Toxicol 2011;49:2243-2251

    12. Jiang WW, Kou JP**,Yuan ST, Sun L,Yu BY*. A simplified and high-throughput chromogenic assay for testing tissue factor-dependent procoagulant activity. J Biomol Screen2011;16:295-302.

    13. Liu K, Zhao WW, Gao XJ, Huang F, Kou JP**, Liu BL*.Diosgenin ameliorates palmitate- induced endothelial dysfunction and insulin resistance via blocking IKK and IRS-1 pathways.Atherosclerosis, 2012,223: 350-358  

    14. Sun Q, Ling Chen L, Gao MY, Jiang WW, Shao FX, Li JJ, Wang J, Kou JP*, Yu BY*. Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-B. Int Immunopharmacol 2012,12:88-93

    15. Guan T, Liu Q, Qian Y, Yang HP, Kong JM, Kou JP*, Yu BY*.Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke.Eur J Pharmacol. 2013,714:303-311

    16. Lv YN, Lu S, Lu T, Kou JP*, Yu BY*. Homology model of nonmuscle myosin heavy chain IIA and binding mode analysis with its inhibitor blebbistatin. J Mol Model. 2013, 19(4):1801-1810.

    17. Gao MY, Chen L, Yu HX, Sun Q, Kou JP*, Yu BY*. Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice.Int Immunopharmacol. 2013,15:240-245

    18. Ge HX, Zhang J, Chen L, Kou JP*, Yu BY. Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorg & Med Chem,2013,21:62–69

    19. Guan T, Liu Q, Qian YS, Yang HP, Kong JM, Kou JP*, Yu BY*. Ruscogenin reduces cerebral ischemic injury via NF-kappa B-mediated inflammatory pathway in the mouse model of experimental stroke. Eur J Pharmacol, 2013,714(1-3)303-311.

    20. Guo ZS, Cao GS, Yang HP, Zhou HN, Li L, Cao ZY, Yu BY, Kou JP*. A Combination of Four Active Compounds Alleviates Cerebral Ischemia-Reperfusion Injury in Correlation With Inhibition of Autophagy and Modulation of AMPK/mTOR and JNK Pathways. J Neurosci Res, 2014, 92(10): 1295-1306.

    21. Gao MY, Chen L, Yang L, Yu X, Kou JP*, Yu BY*. Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-kappa B/p65, Akt and MAPK pathway in THP-1 cells. Pharmacol Rep,2014,66(3): 480-484.

    22. Lv YN, Li SX, Zhai KF, Kou JP*, Yu BY*.Network pharmacology-based prediction and verification of the molecular targets and pathways for schisandrin against cerebrovascular disease. Chin J Nat Med, 2014,12(4): 251-258.

    23. Zhai KF, Tang YM, Zhang YY, Li F, Wang Y, Cao ZY, Yu J*, Kou JP*, Yu BY. NMMHC IIA inhibition impedes tissue factor expression and venous thrombosis via Akt/GSK3 beta-NF-kappa B signalling pathways in the endothelium. Thromb Haemostasis, 2015,114(1): 173-185.

    24. Zhang YY, Sun MH, Han YM, Zhai KF., Tang YM, Qin XY, Cao ZY, Yu BY*, Kou JP*. The saponin DT-13 Attenuates Tumor Necrosis Factor –alpha -induced Vascular Inflammation Associated with Src/NF-kappa B/MAPK Pathway Modulation. Int J Biol Sci , 2015, 11(8): 970-981.

    25. Lin YN, Jia R, Liu YH, Gao Y, Wang LL, Kou JP*, Yu BY*. Ruscogenin suppresses mouse neutrophil activation: Involvement of protein kinase A pathway. J Steroid Biochem Mol Biol , 2015, 154, 85-93.

    26. Zhou KC, Jia NT, Jiang N, Wang F, Kou JP*. Beneficial effect of Danggui-Shaoyao-San, a traditional Chinese medicine, on drowsiness induced by chronic restraint stress. Neurosci Lett, 2015,597: 26-31 .

    27. Li F, Lv YN, Tan YS, Shen K, Zhai KF, Chen HL, Kou JP*, Yu BY*. An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardio-cerebral ischemic diseases. Acta Pharmacol Sinica, 2015,36(11): 1337-1348.  

    28. Shen K, Wang Y, Zhang YY, Zhou HN, Song YF, Cao ZY, Kou JP*, Yu BY. Cocktail of Four Active Components Derived from Sheng Mai San Inhibits Hydrogen Peroxide-Induced PC12 Cell Apoptosis Linked with the Caspase-3/ROCK1/MLC Pathway. Rejuv Res, 2015,18(6): 517-527.

    29. Chen Y, Xu XS, Zhang YY, Liu K, Huang F, Liu BL*, Kou JP*. Diosgenin regulates adipokine expression in perivascular adipose tissue and ameliorates endothelial dysfunction via regulation of AMPK. J Steroid Biochem Mol Biol, 2016,155: 155-165.

    30. Cao GS, Ye XY, Xu YQ, Yin MZ,Chen HL, Kou JP*, Yu BY. YiQiFuMai powder injection ameliorates blood-brain barrier dysfunction and brain edema after focal cerebral ischemia-reperfusion injury in mice.  Drug Design, Develop Therapy, 2016,10:315-325.