YANG, JIE

Release date:2016-05-18  Release:

YANG, JIE

Associate Professor of Chinese Medicines Analysis

Department of Chinese Medicines Analysis

School of Traditional Chinese Pharmacy

Email: 1020092098@cpu.edu.cn

Research Summary

The current research theme in my laboratory integrates pharmacokinetics, drug metabolism/transport, phytochemisry and pharmacology in 2 major foci. (1) Studies of dietary phytochemicals-mediated cellular signaling related to metabolic syndrome. Many natural products have been shown to possess beneficial effects for metabolic syndrome. My laboratory is utilizing the latest molecular, cellular, and LC-MS-MS to interrogate the biological responses elicited by these natural products using a combination of various cell lines coupled with different animal models. (2) Pharmacokinetics and metabonomics of bioactive compounds in Traditional Chinese Medicine. My laboratory investigates the pharmacokinetic behavior of bioactive compounds in TCM. Meanwhile, since pathological states might alter the pharmacokinetics of drugs, we study the differences of their pharmacokinetic behaviors between normal rats and pathological rats to provide scientific data for their clinical efficacy and safety. Furthermore, metabonomics  based  on  the combination of UPLC-Q-TOF with multivariate data analysis is also part of my  study,  aiming  to  discover  biomarkers  for  metabolic  syndrome  and investigate the therapeutic mechanism of TCM.

Education

2009  Ph.D., Pharmacognosy, China Pharmaceutical University

2004  B.S., Traditional Chinese Medicine, China Pharmaceutical University

Academic Experience

2012-present   Associate Professor of Chinese Medicines Analysis, Department of Chinese Medicines Analysis

2009-2012 Department of Chinese Medicines Analysis


Publications

  1. Yi Li, Jing-jing Li, Xiao-dong Wen, Rong Pan, Jie Yang*. Metabonomic analysis of the therapeutic effect of Potentilla discolor in treatment of Type 2 diabetes mellitus. Mol Biosyst.  2014, 10:2898-2914.

  2. Jing-jing Li#, Yi Li#, Jing-fu Tan, Qiang Wang, Jie Yang*. Simultaneous determination of corosolic acid and euscaphic acid in the plasma of normal and diabetic rat after oral administration of extract of Potentilla discolor Bunge by high-performance liquid chromatography/electrospray ionization mass spectrometry. Biomed Chromatogr. 2014, 28(5):717-724.  

  3. Jie Yang#,Fang Lv#, Xiao-qing Chen, Wei-xi Cui, Li-hong Chen, Xiao-dong Wen*, Qiang Wang*. Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/ electrospray ionization mass spectrometry.Journal of pharmaceutical and biomedical analysis. 2013, 77:21-28.

  4. Wei-xi Cui#, Jie Yang# (Co- first author), Xiao-qing Chen, Qian Mao, Xiang-lan Wei, Xiao-dong Wen, Qiang Wang*. Triterpenoid-rich fraction from Ilex hainanensis Merr. Attenuates Non-alcoholic Fatty Liver Disease Induced by High Fat Diet in Rats. The American journal of chinese medicine. 2013, 41(3):487-502.

  5. Jing-jing Li#, Jie Yang# (Co- first author), Wei-xi Cui, Xiao-qing Chen, Gang-ling Chen, Xiao-dong Wen*, Qiang Wang*. Analysis of therapeutic effect of Ilex hainanensis Merr. Extract on nonalcoholic fatty liver disease through urine metabolite profiling by ultra-performance liquid chromatography/quadrupole time of flight mass spectrometry. Evidence-Based Complementary and Alternative Medicine. 2013(2013), Article ID 451975.

  6. Xiao-Dong Wen#, Jie Yang # (Co- first author), Rong-Hua Ma, Wen Gao, Lian-Wen Qi, Ping Li, Brent A. Bauer, Guang-Jian Du, Zhiyu Zhang, Jacqueline Somogyi, Chong-Zhi Wang, Chun-Su Yuan*. Analysis of Panax notoginseng metabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis sampling. Journal of Chromatography B. 2012, 895-896:162-168.

  7. Hong Chen#, Jie Yang# (Co- first author), Qin Zhang, Li-Hong Chen, Qiang Wang*. Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression. Circulation Journal. 2012, 76(4):995-1003.

  8. Rong-Hua Ma#, Jie Yang# (Co- first author), Lian-Wen Qi, Gui-Zhong Xin, Chong-Zhi Wang, Chun-Su Yuan, Xiao-Dong Wen*, Ping Li*. In vivo microdialysis with LC–MS for analysis of spinosin and its interaction with cyclosporin A in rat brain, blood and bile. Journal of Pharmaceutical and Biomedical Analysis. 2012, 62: 22-29.

  9. Jie Yang, Xiao-dong Wen, Bei-xi Jia, Qian Mao, Qiang Wang*, Mao-xiang Lai. Quality evaluation of Potentilla discolor by high-performance liquid chromatography coupled with diode array detection and electrospray ionization tandem mass spectrometry. Phytochemical Analysis. 2011, 22(6):547-554.