YU, BOYANG

Release date:2016-05-18  Release:


YU, BOYANG

Professor of Pharmacognosy

Dean, School of Traditional Chinese Pharmacy

Director, Jiangsu Key Laboratory of TCM Evaluation and Translational Research

Phone: 86-25-86185135

E-mail: boyangyucpu@163.com

Research Summary

Professor YU’s research focuses on the efficacious material basisand mechanism of TCM complex prescriptions, biotechnology of TCM, resources chemistry of TCM, and development of new drugs from TCM. Aiming at the top-quality TCM materials, he is constructing a technical platform of TCM evaluation and translation by integrating multiple modern methods to enhance the level of safety and quality, interpret the action characteristics, understand the efficacious material basis that adapts to clinical indications, and create new drugs of TCM with clear mechanisms, definite therapeutic effects, controllable qualities and proprietary intellectual property rights.

Education

1987,2–1989,11  Ph.D.,Pharmacognosy,

China Pharmaceutical University.

1982,9–1985,6    M.S.,Pharmacognosy,

China Pharmaceutical University.

1978,8–1982,7    B.S.,Traditional Chinese Medicine, Liaoning University of Traditional

Chinese Medicine.

Academic Experience

1997,10–present Professor,School of Traditional Chinese Pharmacy, China Pharmaceutical University

1996,1–1997,9  Visiting Professor, College of Pharmacy, University of Iowa

1995,8–1995,12 Visiting Scholar, College of Pharmacy, University of Illinois at Chicago

1993,6–1997,10  Associate Professor,School of Traditional Chinese Pharmacy, China Pharmaceutical University                

1989,12–1993,5  Assistant Professor, School of Traditional Chinese Pharmacy, China Pharmaceutical University

1988,3–1988,12  Visiting Research Scientist, Department of Pharmaceutical, Showa University

1985,7–1987,2  Assistant, Department of Traditional Chinese Pharmacy, China Pharmaceutical University,


Awards and Honors


2010       Second Prize Award of Science and Technology, Ministry of Education of the P. R. China

2005       First Prize Award of Science and Technology,   Chinese Association of Integrative Medicine

2001       Second Prize Award of National Science and Technology, P. R. China Government.

1997        Third Prize Award of National Science and     Technology, P. R. China Government.

1997        Third Prize Award for National Outstanding  Young Research Investigator, Fork Ying Tung Education Foundation, Hong Kong

1993        Fellowship Award for National Outstanding  Young Research Investigator, Fork Ying Tung Education Foundation, Hong Kong

1993        Fellowship Award for National Outstanding  Young Teacher Working at Universities, State Education Commission

1992        First Prize Award of National Science and      Technology, P. R. China Government

1991       First Prize Award of Science and Technology for Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine

Publications

To date, 11 monographs, 32 invention patents and more than 300 papers have been produced. Selected papers of the recent publications are shown as below:

1.Xu, C. C.; Deng, T.; Fan, M. L.; Lv, W. B.; Liu, J. H.*; Yu, B. Y.* Synthesis and in vitro antitumor evaluation of dihydroartemisinin-cinnamic acid ester derivatives. European Journal of Medicinal Chemistry 2016, 107, 192-203.

2.Tian, J.; Luo, Y.; Huang, L.; Feng, Y.; Ju, H.*; Yu, B. Y.* Pegylated folate and peptide-decorated graphene oxide nanovehicle for in vivo targeted delivery of anticancer drugs and therapeutic self-monitoring. Biosensors & Bioelectronics 2016, 80, 519-524.

3.Qi, J.; Chen, Y. H.; Wang, Y.; Chen, X.; Wang, L.; Hu, Y. J.; Yu, B. Y.* Screening of peroxynitrite scavengers in Flos Lonicerae by using two new methods, an HPLC-DAD-CL technique and a peroxynitrite spiking test followed by HPLC-DAD analysis. Phytochemical Analysis : PCA 2016, 27, 57-63.

4.Yu, Q.; Qi, J.; Wang, L.; Liu, S. J.*; Yu, B. Y.* Pentacyclic triterpenoids from spikes of Prunella vulgaris L. inhibit glycogen phosphorylase and improve insulin sensitivity in 3T3-L1 adipocytes. Phytotherapy Research : PTR 2015, 29, 73-79.

5.Lin, Y. N.; Jia, R.; Liu, Y. H.; Gao, Y.; Wang, L. L.; Kou, J. P.*; Yu, B. Y.* Ruscogenin suppresses mouse neutrophil activation: Involvement of protein kinase A pathway. The Journal of Steroid Biochemistry and Molecular Biology 2015, 154, 85-93.

6.Li, Y. W.; Qi, J.; Zhang, Y. Y.; Huang, Z.; Kou, J. P.; Zhou, S. P.; Zhang, Y.; Yu, B. Y.* Novel cytotoxic steroidal glycosides from the roots of Liriope muscari. Chinese Journal of Natural Medicines 2015, 13, 461-466.

7.Li, F.; Tan, Y. S.; Chen, H. L.; Yan, Y.; Zhai, K. F.; Li, D. P.; Kou, J. P.; Yu, B. Y.* Identification of schisandrin as a vascular endothelium protective component in YiQiFuMai Powder Injection using HUVECs binding and HPLC-DAD-Q-TOF-MS/MS analysis. Journal of Pharmacological Sciences 2015, 129, 1-8.

8.Li, F.; Lv, Y. N.; Tan, Y. S.; Shen, K.; Zhai, K. F.; Chen, H. L.; Kou, J. P.*; Yu, B. Y.* An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardio-cerebral ischemic diseases. Acta pharmacologica Sinica 2015, 36, 1337-1348.

9.Li, D.; Wang, T.; Guo, Y.; Hu, Y.; Yu, B. Y.*; Qi, J.* Online screening of nitric oxide scavengers in natural products using high performance liquid chromatography coupled with tandem diode array and fluorescence detection. Journal of Chromatography. A 2015, 1425, 106-115.

10.Zhang, H.; Chen, L.; Kou, J. P.; Zhu, D. N.; Qi, J.*; Yu, B. Y.* Steroidal sapogenins and glycosides from the fibrous roots of Polygonatum odoratum with inhibitory effect on tissue factor (TF) procoagulant activity. Steroids 2014, 89, 1-10.

11.Chen, Y, H.; Qi, J.; Hua, J.; Yu, B. Y.* Structural characterization and identification of major constituents in radix scrophulariae by HPLC coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Chinese journal of natural medicines 2014, 12, 47-54.

12.Yan, Y.; Chai, C. Z.; Wang, D. W.; Wu, J.; Xiao, H. H.; Huo, L. X.; Zhu, D. N.; Yu, B. Y.* Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2014, 95, 76-84.

13.Xu, Y.; Liu, J. H.*; Wang, J.; Zhang, J.; Yu, B. Y.* A monoclonal antibody-based competitive ELISA for the determination of ruscogenin in Chinese traditional medicines and biological samples. Chinese Journal of Natural Medicines 2014, 12, 794-799.

14.Wang, H. Y.; Hua, H. Y.; Liu, X. Y.; Liu, J. H.*; Yu, B. Y.* In vitro biotransformation of red ginseng extract by human intestinal microflora: metabolites identification and metabolic profile elucidation using LC-Q-TOF/MS. Journal of Pharmaceutical and Biomedical Analysis 2014, 98, 296-306.

15.Lv, Y. N.; Li, S. X.; Zhai, K. F.; Kou, J. P.*; Yu, B. Y.* Network pharmacology-based prediction and verification of the molecular targets and pathways for schisandrin against cerebrovascular disease. Chinese Journal of Natural Medicines 2014, 12, 251-258.

16.Li, Y. W.; Qi, J.; Wen, Z.; Zhou, S. P.; Yan, W.; Yu, B. Y.* Determination and fingerprint analysis of steroidal saponins in roots of Liriope muscari (Decne.) L. H. Bailey by ultra high performance liquid chromatography coupled with ion trap time-of-flight mass spectrometry. Journal of Separation Science 2014, 37, 1762-1772.

17.Hua, J.; Qi, J.; Yu, B. Y.* Iridoid and phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl. and their alpha-glucosidase inhibitory activities. Fitoterapia 2014, 93, 67-73.

18.Gao, M. Y.; Chen, L.; Yang, L.; Yu, X.; Kou, J. P.*; Yu, B. Y.* Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-kappaB/p65, Akt and MAPK pathway in THP-1 cells. Pharmacological Reports : PR 2014, 66, 480-484.

19.Yu, Q.; Qi, J.; Yu, H. X.; Chen, L. L.; Kou, J. P.; Liu, S. J.; Yu, B. Y.* Qualitative and quantitative analysis of phenolic compounds in the leaves of aquilaria sinensis using liquid chromatography-mass spectrometry. Phytochemical analysis : PCA 2013, 24, 349-356.

20.Yan, Y.; Chai, C. Z.; Wang, D. W.; Yue, X. Y.; Zhu, D. N.*; Yu, B. Y.* HPLC-DAD-Q-TOF-MS/MS analysis and HPLC quantitation of chemical constituents in traditional Chinese medicinal formula Ge-Gen Decoction. Journal of Pharmaceutical and Biomedical Analysis 2013, 80, 192-202.

21.Wang, Y. Q.; Zhang, J. Q.; Liu, C. H.; Zhu, D. N.; Yu, B. Y.* Screening and identifying the myocardial-injury protective ingredients from Sheng-Mai-San. Pharmaceutical Biology 2013, 51, 1219-1227.

22.Wang, Y. Q.; Liu, C. H.; Zhang, J. Q.; Zhu, D. N.; Yu, B. Y.* Protective effects and active ingredients of yi-qi-fu-mai sterile powder against myocardial oxidative damage in mice. Journal of Pharmacological Sciences 2013, 122, 17-27.

23.Ge, H. X.; Zhang, J.; Chen, L.; Kou, J. P.*; Yu, B. Y.* Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorganic & Medicinal Chemistry 2013, 21, 62-69.

24.Ding, X. P.; Zhang, C. L.; Qi, J.; Sun, L. Q.; Qin, M. J.; Yu, B. Y.* The Spectrum-Effect integrated fingerprint of Polygonum cuspidatum based on HPLC-diode array detection-flow injection-chemiluminescence. Chinese Journal of Natural Medicines 2013, 11, 546-552.

26.Chen, L. L.; Hu, Z. F.; Ding, X. P.; Qi, J.; Zhu, D. N.; Yu, B. Y.* Identification and determination of the major triterpenes in Rhizoma Alismatis by HPLC-evaporative light scattering detection and HPLC/electrospray ionization-MS. Journal of AOAC International 2013, 96, 260-264.

27.Xia, Y.; Liu, J. H.*; Liu, J. H.; Yu, B. Y.* Efficient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase. Bioorganic & Medicinal Chemistry Letters 2012, 22, 3100-3103.

28.Ge, H. X.; Zhang, J.; Dong, Y.; Cui, K.; Yu, B. Y.* Unique biocatalytic resolution of racemic tetrahydroberberrubine via kinetic glycosylation and enantio-selective sulfation. Chemical Communications (Cambridge, England) 2012, 48, 6127-6129.

29.Ding, X. P.; Wang, X. T.; Chen, L. L.; Guo, Q.; Wang, H.; Qi, J.; Yu, B. Y.* On-line high-performance liquid chromatography-diode array detection-electrospray ionization-mass spectrometry-chemiluminescence assay of radical scavengers in Epimedium. Journal of Chromatography. A 2011, 1218, 1227-1235.

30.Chai, C.; Kou, J.; Zhu, D.; Yan, Y.; Yu, B.* Mice Exposed to Chronic Intermittent Hypoxia Simulate Clinical Features of Deficiency of both Qi and Yin Syndrome in Traditional Chinese Medicine. Evidence-based Complementary and Alternative Medicine : eCAM 2011, 2011, 356252.