CHEN, LI

Release date:2016-05-18  Release:

CHEN, LI

Professor of Natural Medicinal Chemistry

School of Traditional Chinese Medicines

Phone: 86-25-83271447

Email: chenli627@cpu.edu.cn

Research Summary

Professor CHEN’s research focuses on the modification of natural compounds, especially for design, synthesis and bioactivity of active natural molecules for drug discovery. She has published dozens of papers on NO-donating derivatives of natural triterpene (including Oleanolic Acid, Ursolic acid, Betulinic acid ), diterpene (e.g. isosteviol) and so on, and some of these compounds exhibited desirable anti-cancer activity. Recently, Professor CHEN’s major interests involve target-based drug design such as the approach to identify possible STAT3, HSP90, MRP1 inhibitors and rational ligand-based drug design. In addtion, Professor CHEN also has interest in design and synthesis of analogues based on the SARs and structure of the targets in order to enhance the activity or stability and reduce the toxicity of lead compounds (e.g. CDDOs).

Education

2004   Ph.D., Medicinal Chemistry, China Pharmaceutical University

1996   M.S., Natural Medicinal ChemistryShandong Academy of Medical Sciences

1988   B.S., Medicinal Chemistry, China Pharmaceutical University

Academic Experience

2011-  Professor of Natural Medicinal Chemistry, China Pharmaceutical University

2012-2013 Visiting Scholar of Medicinal Chemistry and Pharmacognosy, The University of Illinois at Chicago (UIC), USA

2004-2011  Associate Professor of Natural Medicinal Chemistry, China Pharmaceutical University

1996-2004 Lecturer of Natural Medicinal Chemistry, China Pharmaceutical University

Awards and Honors

2004  Second Prize, for the 7th Scientific Communion meeting of the National Youth Pharmaceutical Researchers, Chinese Pharmaceuticl Association

2004  Third Prize, for the 5th Academic Annual meeting, Chinese Pharmaceuticl Association

Publications

1. Li LH, Zhao P, Hu JL, Liu JH, Liu Y, Wang ZQ, Xia YF*, Dai Y, Chen L*. Synthesis, in vitro and in vivo antitumor activity of scopoletin-cinnamic acid hybrids. Eur J Med Chem, 2015, 93: 300-307. SCI, IF = 3.447

2. Ling YWang ZQWang XMLi XHWang XYZhang WDai H*Chen, L*Zhang YH. Hybrid molecule from FTS-diamine and phenylpropenoic acid as Ras-related signaling inhibitor with potent antitumor activities. Chem Biol Drug Des.2015; 85: 145–152 SCI, IF = 2.485

3. Liu JH, Zhu ZF, Tang J, Jiang AQ*, Hu LF, Chen L*. Novel NO-releasing derivatives of betulinic acid with antitumor activity, Chin Chem Lett,2015, 26: 759-762. SCI, IF = 1.587

4. Zhao P#, Chen L#, Li LH, Wei ZF, Tong B, Jia YG, Kong LY, Xia YF*, Dai Y*. SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. BMC Cancer, 2014, 14: 987-999. SCI, IF = 3.362

5.Wang TT, Liu Y, Chen L*. Synthesis and cytotoxic activity of nitric oxide-releasing isosteviol derivatives. Bioorg. Med. Chem. Lett., 2014, 24: 2202-2205. (SCI, IF = 2.420)

6. Chen, L.; Zhang, Y.; Kong, X.; Lan, E.; Huang, Z.; Peng, S.; Kaufman, D. L.; Tian, J. Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid. J Med Chem2008, 51, 4834-4838. SCI, IF = 4.898