HUANG, XUEFENG

Release date:2016-05-18  Release:




HUANG, XUEFENG

Associate Professor of Traditional Chinese Medicine

School of Traditional Chinese Pharmacy

Phone: 86-25-86185292

Email: hxf@cpu.edu.cn

Research Summary

Associate ProfessorHuang focuses on finding drugs or lead compounds from natural products. His current research interest is to monitor the potential of plant extracts of clinically used anticancer traditional Chinese herbs to reverse tumor cell multiple drug resistance. Especially the research in several major areas will be undertaken with the main emphasis on utilization of folk herbs (Asparagus officinalis L., Anemarrhena asphodeloides Bunge. and Salvia miltiorrhiza Bunge.) for development of natural products as inhibitors of chemical carcinogenesis, biological evaluation.

Education

2005   Ph.D., Chinese medicinal chemistry, China Pharmaceutical University

2002   M.S., Natural Medicinal Chemistry, China Pharmaceutical University

1994   B.S., Pharmcy, Shaanxi College of Traditional Chinese Medicine

Academic Experience

2009-      Associate Professor of Traditional Chinese Medicine, China Pharmaceutical University

2008-2013  Lecturer of Traditional Chinese Medicine, China Pharmaceutical University

Publications

  1. Xinghuan Sun, Futao Zhu, Yuwei Zhang, Fangfang Chen, Yun Yu, Ningning Song, Xuefeng Huang*, Two new steroidal saponins from Anemarrhena asphodeloides Bunge.Chinese Journal of Natural Medicines, accepted.

  2. Rui Ning, Xiaoping Wang, Yunran Zhan, Qi Qi, Xuefeng Huang, Gang Hu, Qinglong Guo, Wei Liu*, Jian Yang*, Gambogic acid potentiates clopidogrel-induced apoptosis and attenuates irinotecan-induced apoptosis through down-regulating human carboxylesterase 1 and -2, Xenobiotica, 2016, 1, DOI: 10.3109/00498254.2015.1125560,

  3. Wei Liu, Rui Ning, Ruini Chen, Xuefeng Huang, Qinsheng Dai, Uinhua Hu, Yuwen Wang, Lili Wu, Jing xiong, Gang Hu, Qinglong Guo, Jian Yang*, Hao Wang*, Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells,Molecular carcinogenesis, 2016, 55(5): 440-457

  4. Wei Li, Shuiping Zhou*, Yuanpeng Jin, Xuefeng Huang*, Wei Zhou, Min Han, Yun Yu, Kaijing Yan, Shuming Li, Xiaohui Ma, Zhixin Guo, Yonghong Zhu, He Sun. Salvianolic acids T and U: a pair of atropisomeric trimeric caffeic acids derivatives from root of Salvia miltiorrhiza. Fitoterapia, 2014 (98): 248-253.

  5. Ke Ma, Xuefeng Huang*, Lingyi Kong*, Steroidal Saponins from Polygonatum cyrtonema, Chemistry of Natural Compound, 2013, 49 (5): 888-891.

  6. Futao Zhu, Xuefeng Huang*, Lingyi Kong*. Steroidal Saponins from Anemarrhena asphodeloides Bge., Natural Product Research and Development, 2012, 24 (11): 1497-1501, 1570.

  7. Zhouxuan Sun, Xuefeng Huang, Lingyi Kong*, A new steroidal saponin from the dried stems of Asparagus officinalis L, Fitoterapia, 2010, 81 (3): 210-213.

  8. Renjie Yin, Xuefeng Huang, Lingyi Kong*, Constituents from the heartwoods of Osmanthus armatus, Natural Product Research, 2010, 24 (10): 948-952.

  9. Minghua Yang, Jianguang Luo, Xuefeng Huang, Lingyi Kong*, Flavonol glycosides with D-aldohexoses from Rhododendron irroratum, Natural Product Research, 2010, 24 (10): 920-925.

  10. Wei Liu, Xuefeng Huang ( co-first author), Qi Qi, Qinsheng Dai, Li Yang, Feifei Nie, Na Lu, Dandan Gong, Lingyi Kong*, Qinglong Guo*, Asparanin A induces G(2)/Mcell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, Biochemical and Biophysical Research Communications, 2009, 381(4): 700-705.

  11. Jun Luo, Junsong Wang, Xiaobing Wang, Xuefeng Huang, Jianguang Luo, Lingyi Kong*, Chukvelutilides A-F, phragmalin limonoids from the stem barks of Chukrasia tabularis var. velutina, Tetrahedron, 2009, 65(17): 3425-3431.

  12. Li Ma, Yucheng Gu, Jianguang Luo, Junsong Wang, Xuefeng Huang, Lingyi Kong*, Triterpenoid Saponins from Dianthus versicolor, Journal of Natural Products, 2009, 72(4): 640-644.

  13. Qing Chen, Shun Yao, Xuefeng Huang, Jianguang Luo, Junsong Wang, Lingyi Kong*, Supercritical fluid extraction of Coriandrum sativum and subsequent separation of isocoumarins by high-speed counter-current chromatography, Food chemistry, 2009, 117(3): 504-508.

  14. Yuanyuan Lu, Jianguang Luo, Xuefeng Huang, Lingyi Kong*, Four new steroidal glycosides from Solanum torvum and their cytotoxic activities, Steroids. 2009, 74(1): 95-101.

  15. Xiaolu Zhu, Minghua Yang, Jianguang Luo, Xuefeng Huang, Lingyi Kong*, A new phenylpropanoid from Alpinia galanga, Chinese Journal of Natural Medicines, 2009, 7(1): 19-20.

  16. Zhouxuan Sun, Xuefeng Huang, Lingyi Kong*,Chemical constituents from the stems of Asparagus officinalis, Modern Chinese Medicine, 2009,11 (6): 9-11.

  17. Xuefeng Huang, Yuying Lin, Lingyi Kong*.Steroids from the roots of Asparagus officinalis and their cytotoxic activity.Journal of Integrative Plant Biology, 2008,50 (6): 717-722.

  18. Yongqin Yin,Xuefeng Huang, Lingyi Kong*, Niwa Masatake, Three New Pentasaccharide Resin Glycosides from the Roots of Sweet Potato (Ipomoea batatas), Chemical & Pharmaceutical Bulletin, 56 (12): 1670-1674, 2008.

  19. Xiang Wan, Haili Liu, Xuefeng Huang, Jianguang Luo, Lingyi Kong*, Biotransformation of caffeic acid by Momordica charantia peroxidase, Canadian Journal of Chemistry-Revue Canadienne de Chimie, 2008,86 (8): 821-830.

  20. Xiaolu Zhu, Yinghui Du, Xuefeng Huang, Lingyi Kong*,Studies on the chemical constituents of Alpinia Calanga Willd., Modern Chinese Medicine, 2008,10 (11): 13-15.

  21. Yuanyuan Lu, Jianguang Luo, Deran Xu, Xuefeng Huang, Lingyi Kong*, Characterization of spirostanol saponins in Solanum torvum by high-performance liquid chromatography/evaporative light scattering detector/electrospray ionization with multi-stage tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 2008,22 (16): 2447-2452.

  22. Shun Yao, Jianguang Luo, Xuefeng Huang, Lingyi Kong*. Application of preparative high-speed counter-current chromatography/preparative high-performance liquid chromatography mode in rapid separation of saponins, Journal of Chromatography B, 2008,864 (1-2): 69-77.

  23. Shun Yao, Renming Liu, Jianguang Luo, Xuefeng Huang, Lingyi Kong*. Methodology research of high-speed counter-current chromatography in separation of natural products, Chinese Journal of Natural Medicines, 2008,6 (1): 13-19

  24. Haili Liu,Xuefeng Huang, Xiang Wan, Lingyi Kong*. Biotransformation of p-Coumaric Acid (=(2E)-3-(4-Hydroxyphenyl)prop-2-enoic Acid) by Momordica charantia Peroxidase Biotransformation of p-Coumaric Acid (=(2E)-3-(4-Hydroxyphenyl)prop- 2-enoic Acid) by Momordica charantia Peroxidase. Helvetica Chimica Acta, 2007, 90(6): 1117-1132.

  25. Haili Liu, Xiang Wan, Xuefeng Huang, Lingyi Kong*. Biotransformation of Sinapic Acid Catalyzed by Momordica charantia Peroxidase.Journal of Agricultural and Food Chemistry. 2007, 55(3): 1003-1008.

  26. Shun Yao, Renming Liu, Xuefeng Huang, Lingyi Kong*.Preparative isolation and purification of chemical constituents from the root of Adenophora tetraphlla by high-speed counter-current chromatography with evaporative light scattering detection. Journal of Chromatography A, 2007,1139(2): 254-262.

  27. Xuefeng HuangJun LuoYong ZhangLingyi Kong*. Studies on lignan components of Asparagus officinalisChinese Pharmaceutical Journal2007, 42(5): 339-340,348.

  28. Xuefeng Huang, Lingyi Kong*. Steroidal Saponins from Roots of Asparagus officinalis. Steroids. 2006,71(2): 171-176.

  29. Xuefeng Huang, Jun Luo, Yong Zhang, Lingyi Kong*.Chemical constituents of Asparagus officinalis, Chinese Journal of Natural Medicines, 2006, 4(3): 181-184.

  30. Xuefeng Huang, Fan Li, Cailiang Chen, Lingyi Kong*, Chemical studies on the herb of Chenopodium ambrosioides,Chinese Journal of Natural Medicines, 2003,1(1):24-26.

  31. Xuefeng Huang, Lingyi Kong*, Study on chemical constituents of volatile oil from Chenopodium ambrosioides L.,Journal of China Pharmaceutical University, 2002, 33(3): 256-257.