LIU, KANG

Release date:2016-05-18  Release:

LIU, KANG

Associate Professor of Pharmacology of Chinese Materia Medica

School of Chinese Medicine

Phone: 86-25-86185127

Email: liukangcpu@cpu.edu.cn

Research Summary

Dr. LIU’s group explore the effects of polyphenols and other bioactive extracts derived from Traditional Chinese Medicine on metabolic diseases under insulin resistant conditions, focusing on the regulation of mitochondrial function, inflammation and insulin signaling. Dr. LIU is now in charge of a study supported by National Natural Science Foundation of China: Rare ginsenosides protect the heart against ischemia-reperfusion injury in the setting of insulin resistance: based on the regulation of Randle cycle (8157140264). Furthermore, she also undertakes the task of teaching: physiology, pharmacology and pharmacology of Chinese Materia Medica.

Education

2005       Ph.D., Immunopharmacology, China Pharmaceutical University

1998       M.S., PharmacologyChina Pharmaceutical University

1993       B.S.,   Pharmacology of Chinese Materia Medica, China Pharmaceutical University

Academic Experience

2011-      Associate Professor of Pharmacology of Chinese Materia Medica, Department of Pharmacology of Chinese Materia Medica

1998-2011Lecturer of Pharmacology of Chinese Materia Medica, Department of Pharmacology of Chinese Materia Medica

Publications

  1. Liu K, Mei F, Wang Y, Xiao N, Yang L, Wang Y, Li J, Huang F, Kou J, Liu B, Qi LW*. Quercetin oppositely regulates insulin-mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation. Mol Nutr Food Res. 2016, 60(3): 551-65.

  2. Li J, Wang Y, Wang Y, Wen X, Ma XN, Chen W, Huang F, Kou J, Qi LW, Liu B, Liu K*. Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction. J Mol Cell Cardiol. 2015, 86: 62-74.

  3. Wu J, Xu X, Li Y, Kou J, Huang F, Liu B, Liu K*. Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells, Eur J Pharmacol, 2014,745: 59-68.

  4. Sun Y, Li J, Xiao N, Wang M, Kou J, Qi L, Huang F, Liu B, Liu K*. Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1, Pharmacol Res, 2014, 89: 19-28.

  5. Xiao N, Mei F, Sun Y, Pan G, Liu B, Liu K*. Quercetin, luteolin, and epigallocatechin gallate promote glucose disposal in adipocytes with regulation of AMP-activated kinase and/or sirtuin 1 activity. Planta Med, 2014, 80: 993-1000.

  6. M Wang, XJ Gao, WW Zhao, WJ Zhao, S Jiang, F Huang, JP Kou, BL Liu and K Liu*. Opposite effects of genistein on regulation of insulin-mediated glucose homeostasis in adipose tissue. Br J Pharmacol, 2013, 170: 328-40.

  7. Liu K, Zhao W, Gao X, Huang F, Kou J*, Liu B*, Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways, Atherosclerosis, 2012, 223 (2): 350-358.

  8. Liu K, Luo T, Zhang Z, Wang T, Kou J, Liu B, Huang F*, Modified Si-Miao-San extract inhibits inflammatory response and modulates insulin sensitivity in hepatocytes through an IKKβ/IRS-1/Akt-dependent pathway, J Ethnopharmacol, 2011, 136 (3): 473-479.

  9. Kang L, Heng W, Yuan A, Baolin L, Fang H*, Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: Relative to inhibition of inflammatory responses, Biochimie, 2010, 92 (7): 789-796.

  10. Gao X, Liu K, Huang F, Zhang D, Guo X, Wang M, Liu B*, Positive and negative regulation of insulin action by genistein in the endothelium, J Nutr Biochem, 2013, 24 (1): 222-230.

  11. Shao L, Liu K, Huang F, Guo X, Wang M, Liu B*, Opposite effects of quercetin, luteolin, and epigallocatechin gallate on insulin sensitivity under normal and inflammatory conditions in mice, Inflammation, 2013, 36 (1): 1-14.

  12. Huang F, Liu K, Du H, Kou J, Liu B*, Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner, Biochimie, 2012, 94 (5): 1143-1150.

  13. Deqiu Z, Kang L, Jiali Y, Baolin L, Gaolin L*, Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium, Biochimie, 2011, 93 (3): 506-512.