WANG, XIAOBING

Release date:2016-05-18  Release:


 

WANG, XIAOBING

Associate Professor of Natural Medicinal Chemistry

School of Traditional Chinese Medicine

Phone: 86-25-83271402

Email: xbwang@cpu.edu.cn

Research Summary

Dr. WANG’s research focuses on the natural bioactive compounds from the Traditional Chinese Medicine. The major research fields are the rational drug design and study based on natural products against neurodegenerative diseases, such as Alzheimer diseases, Parkinson diseases, and so on, the total synthesis and the structure modification of natural products, the biotransformationand biocatalysis of natural products.

Education

2008       Ph.D., Medicinal Chemistry, China Pharmaceutical University

2005       M.S., Organic ChemistryShaanxi Normal University

2001       B.S.,   Chemical EducationHanzhong Teacher’s College

Academic Experience

2015-2016  Research Scholar, The Scripps Research Institute

2011-     Associate Professor of Natural Medicinal Chemistry, China Pharmaceutical University

2008-2011  Senior Research Scientist of Natural Medicinal Chemistry, China Pharmaceutical Universit

Awards and Honors

2015 The study and application of the new isolation technology of the bioactive ingredients from natural medicines and TCMs, National Science and Technology Progress Award (Second prize), The State Council of P. R. China

2013 The study on the bioactive ingredient of some valuable medicinal plants, Jiangsu Province Science and Technology Award (First prize), Jiangsu Provincial Government

2012 The establishment of new method system on isolation of TCM chemical components and study on quality control of related TCM, Science and Technology Award (Second prize), Ministry of Education

Publications

  1. Zhi-Min Wang, Sai-Sai Xie, Xue-Mei Li, Jia-Jia Wu, Xiao-Bing Wang*, Ling-Yi Kong*. Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-beta-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease. RSC Advances, 2015, 5, 70395-70409 (IF 3.84)

  2. Zhi-Min Wang, Xue-Mei Li, Gui-Min Xue, Wei Xu, Xiao-Bing Wang*, Ling-Yi Kong*. Synthesis and evaluation of 6-substituted 3-arylcoumarin derivatives as multifunctional acetylcholinesterase/monoamine oxidase B dual inhibitors for the treatment of Alzheimer’s disease. RSC Adv, 2015, 5, 104122-104137.

  3. Zhi-Min Wang, Xue-Mei Li, Wei Xu, Fan Li, Jin Wang, Ling-Yi Kong*, Xiao-Bing Wang*. Acetophenone derivatives: novel and potent small molecule inhibitors of monoamine oxidase B. Med Chem Commun, 2015, 6, 2146-2157.

  4. Jin-Shuai Lan, Sai-Sai Xie, Ming Huang, Ya-Jian Hu, Ling-Yi Kong*, Xiao-Bing Wang*. Chromanones: selective and reversible monoamine oxidase B inhibitors with nanomolar potency. Med Chem Commun, 2015, 6, 1293-1302.

  5. Jin-Shuai Lan, Long-Fei Pan, Sai-Sai Xie, Xiao-Bing Wang*, Ling-Yi Kong*. Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors. MedChemComm, 2015, 6, 592-600.

  6. Ming Huang, Sai-Sai Xie, Neng Jiang, Jin-Shuai Lan, Ling-Yi Kong*, Xiao-Bing Wang*. Multifunctional coumarin derivatives: Monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 508-513.

  7. Ya-Jian Hu, Xiao-Bing Wang*, Su-Yi Li, Sai-Sai Xie, Kelvin D. G. Wang, Ling-Yi Kong*. Facile synthesis of spiro chromanone-tetrahydrothiophenes with three contiguous stereocenters via sulfa-Michael/aldol cascade reactions. Tetrahedron Letters, 2015, 56, 105-108.

  8. Ya-Jian Hu, Neng Jiang, Sai-Sai Xie, Su-Yi Li, Jin-Shuai Lan, Ling-Yi Kong*, Xiao-Bing Wang*. Iodine-promoted sequential Michael and oxidative dehydrogenation processes: synthesis of trisubstituted methanes containing a coumarin and a chromone ring. Tetrahedron, 2015, 71, 8026-8032.

  9. Xiao-Bing Wang#, Chang-Shui Yang#, Chao Zhang, Jun Luo, Ming-Hua Yang, Jian-Guang Luo, Wen-Ying Yu, Ling-Yi Kong*. Ten new calyxins from Alpinia katsumadai: a systematically studies on the stereochemistry of calyxins. Tetrahedron, 2014, 70, 8714-8722.

  10. Su-Yi Li, Neng Jiang, Sai-Sai Xie, Kelvin D. G. Wang, Xiao-Bing Wang*, Ling-Yi Kong*. Design, synthesis and evaluation of novel tacrine rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease. Organic & Biomolecular Chemistry, 2014, 12, 801-814.

  11. Jin-Shuai Lan, Sai-Sai Xie, Su-Yi Li, Long-Fei Pan, Xiao-Bing Wang*, Ling-Yi Kong*. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 2014, 22, 6089-6104.

  12. Neng Jiang, Su-Yi Li, Sai-Sai Xie, Hequan Yao, Hongbin Sun, Xiao-Bing Wang*, Ling-Yi Kong*. FeCl3 and ether mediated direct intramolecular acylation of esters and their application in efficient preparation of xanthone and chromone derivatives. RSC Advances, 2014, 4, 63632-63641.

  13. Neng Jiang, Su-Yi Li, Sai-Sai Xie, Zhong-Rui Li, Kelvin D.G. Wang, Xiao-Bing Wang*, Ling-Yi Kong*. Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease, European Journal of Medicinal Chemistry, 2014, 87, 540-551.

  14. Sai-Sai Xie, Xiao-Bing Wang*, Jiang-Yan Li, Lei Yang, Ling-Yi Kong*. Design, synthesis and evaluation of novel tacrine coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease. European Journal of Medicinal Chemistry, 2013, 64, 540-553.

  15. Sai-Sai Xie, Xiao-Bing Wang*, Jiang-Yan Li, Ling-Yi Kong*. Design, Synthesis and Biological Evaluation of Novel 7-Mercaptocoumarin Derivatives as alpha(1)-Adrenoceptor Antagonists. Chemical & Pharmaceutical Bulletin, 2013, 61, 16-24.

  16. Xiao-Bing Wang#, Yao Zhang#, Jun-Song Wang, Yu-Cheng Gu, Ling-Yi Kong. Novel ring A rearranged isomers with gamma-lactone from the fruits of Aphanamixis grandifolia. Tetrahedron Letters, 2013, 54, 6023-6028.

  17. Xiao-Bing Wang, Wei Liu, Lei Yang, Qing-Long Guo, Ling-Yi Kong. Investigation on the substitution effects of the flavonoids as potent anticancer agents: a structure-activity relationships study. Medicinal Chemistry Research, 2012, 21, 1833-1849.

  18. Xiao-Bing Wang, Yao Zhang, Jun-Song Wang, He-Quan Yao, Hong-Bin Sun, Ling-Yi Kong. Spectroscopic characterizations, X-ray studies, and electronic circular dichroism calculations of two alkaloid triterpenoids. Structural Chemistry, 2011, 22, 1241-1248.