WU, FEIHUA

Release date:2016-05-19  Release:


WU, FEIHUA

Associate Professor of Pharmacology of Chinese Materia Medica

School of Traditional Chinese Pharmacy,

Phone: +86-13057621416

Email: fhwu2000@sina.com

Research Summary

WU’s research focuses on investigating the effect of anti-diabetic drugs and its mechanism, exploring substance basis of Chinese medicine and developing new drug. Firstlywe explore vascular impairment and biochemical changes in type 2 diabetic rats or mice induced by high fat diet and low dose streptozotocin.Secondly, we investigate high glucose-induced apoptosis or free fatty acid-induced vascular endothelial cell and hepatocyte insulin resistance. We also investigatethe mechanism of vascular dysfunction involved with Toll-like receptor 4 and NLRP3 inflammasome pathway and drug treatment. In addition, we investigate the pathophysiology of airway inflammation in a mouse model of allergic airway disease and drug treatment. We also pay attention to isolating and identifying active compounds from medicinal plants such as Clinopodium chinenseand Saliva plebeian, developing novel natural products in collaboration with other research team.

Education

2005Ph.D., Natural Medicinal Chemistry, China Pharmaceutical University

1996M.S., Pharmacology, China Pharmaceutical University

1993B.S., Pharmaceutical Chemistry and Engineering, China Pharmaceutical University

Academic Experience

2006-present:   Associate Professor, Pharmacology of Chinese Materia Medica, China Pharmaceutical University.

2015-2016    Associate Professor, Visiting scholar,University of Michigan, Ann Arbor, U.S.A

1999-2006:     Instructor, Pharmacology of Chinese Materia Medica, China Pharmaceutical University.

1997-1997:  Visiting scholar, Toyama Medical and Pharmaceutical University, Toyama, Japan.

1996-1999: Teaching Assistant of Pharmacology of Chinese Materia Medica, China Pharmaceutical University.  

Awards and Honors

2014, Academic Leaders Training Award, Qing Lan Project of Jiangsu Province

2013, Training Award of fourth term of the third level "333 project", Jiangsu Province

2012, Excellent Project Award, Mentor for the National Undergraduate Innovative Experiment Project, China Pharmaceutical University

Publications

  1. Bei Ren, Weiwei Qin, Feihua Wu*, Shanshan Wang, Cheng Pan, Liying Wang, Biao Zeng, Shiping Ma, Jingyu Liang. Apigenin and naringenin regulate glucose and lipid metabolism,andameliorate vascular dysfunction in type 2 diabetic rats. Eur. J. Pharmacol., 2016, 773:13–23

  2. Baiqiu He, Baobao Zhang, Feihua Wua*, Liying Wang, Xiaoji Shi., Weiwei Qin, Yining Lin, Shiping Ma, Jingyu Liang. Homoplantaginin inhibits palmitic acid-induced endothelial cells inflammtion via suppressing TLR4 and NLRP3 inflammasome. J. Cardiovasc. Pharm., 2016, 67(1): 93101

  3. Baobao Zhang, Baiqiu He, Jianbo Sun, Biao Zeng, Xiaoji Shi, Yong Zhou, Ying Niu, Shiqi Nie, Feng Feng, Yan Liang*, FeihuWu*. Diterpenoids from Saliva plebeian R. Br. and their antioxidant and anti-inflammatory activities. Molecules, 2015, 20: 1487914888.

  4. Zhihong Zhou, Minzhuo Liu, Menghua Wang, Wei Qu, Jianbo Sun, Jingyu Liang*, Feihua Wu*. A new ellagic acid derivative from Polygonum runcinatum. Nat. Prod. Res., 2015, 29(9): 795–799

  5. T.S. Cheung, T.H. Song, T.B. Ng, F.H. Wu, L.X. Lao, S.C.W. Tan, J.C.M. Ho, K.Y.B. Zhang*, S.C.W. Sze* Therapeutic Effects of Herbal Chemicals in Traditional Chinese Medicine on Alzheimer’s Disease. Curr. Med. Chem., 2015, 22(19): 23922403

  6. Zhihong Zhou, Wei Qu, Minzhuo Liu, Jianbo Sun, Menghua Wang, Jingyu Liang*, Feihua Wu*. A new taxane diterpenoid from Taxus chinensis var. mairei. Nat Prod Res, 2014, 28(8): 530–533

  7. Menghua Wang, Linzhen Li, Jianbo Sun, Feihua Wu*, Jing-Yu Liang*. A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi. Nat. Prod. Res., 2014, 28(20): 1772–1776

  8. Juan Li, Feihua Wu*, Kai Chen, Jingyu Liang, Shiping Ma. Extract of Clinopodium chinense inhibits high glucose-induced apoptosis in Human Umbilical Vein Endothelial Cells. J. Cardiovasc. Pharm., 2013, 61(4):265271

  9. Jianbo Sun, Wei Qu, Pei Wang, Feihua Wu*, Liying Wang, Jingyu Liang*. Degraded limonoids and quinoline alkaloids from Dictamnus angustifolius G. Don ex Sweet. and their anti-platelet aggregation activity. Fitoterapia, 2013, 90: 209-213

  10. Liping Lin, Feihua Wu*, Jingyu Liang*. The first examples of ilexgeninA hybrids as a new class of multi-potent, anti-platelet agents. Chinese Chem. Lett., 2013, 24: 723726

  11. Feihua Wu, Hui Wang, Juan Li, Jingyu Liang, Shiping Ma. Homoplantaginin modulates insulin sensitivity in endothelial cells by inhibiting inflammation. Biol. Pharm. Bull., 2012, 35(7)1171–1177

  12. Youyi Xiong, Feihua Wu, Junsong Wang, Juan Li, Lingyi Kong*. Attenuation of airway hyperreactivity and T helper cell type 2 responses by coumarins from Peucedanum praeruptorum Dunn in a murine model of allergic airway inflammation. J. Ethnopharmacol, 2012, 141(1)314–321

  13. Jingyu Zhang, Feihua Wu, Wei Qu, Jingyu Liang*. Two new cassane diterpenoids from the seeds of Caesalpinia sappan Linn. Chin. J. Nat. Med, 201210(3)218–221