ZHANG, JIAN

Release date:2016-05-19  Release:

 

ZHANG, JIAN

Professor of Pharmacognosy

School of Traditional Chinese Medicine

Phone: 86-25-86185158

Email: 1020071849@cpu.edu.cn

Research Summary

Professor Zhang is engaged on the biotransformation, biocatalysis, and biocatalytic manufacture of active natural products. His main research areas are biological cultures involved in the structural modification of pentacyclic triterpenes and protoberberines and their potential activities evaluation. Besides the use of different optimization strategies for experimental design and process development the attention is directed towards intensive kinetic analysis of the reactions involved. The research focuses on glycosyltransferases that can make glycosidic bonds between sugar units (donors) and natural products (acceptors).

Education

2005 Ph.D., Pharmacognosy, China Pharmaceutical University

2000 B.S., Biotechnology and PharmacyChina Pharmaceutical University,NanJing University

Academic Experience

2005-2009  Postdoctoral Fellow of State Key Laboratory of Pharmaceutical BiotechnologyNan Jing University

Awards and Honors

2012     Fellowship of the Program for New Century Excellent Talents in University, Ministry of Education, China.

Publications

  1. Xu Shao-Hua, Du Chen-Hui, Zhang Jian*, Yu Bo-YangGlycosylation and sulfation of emodin by Gliocladium deliquescens NRRL 1086Chinese Journal of Natural Medicines, 2015, 13(10), 796-800.

  2. Hai Xia Ge, Jian Zhang*, Li Lan Lu, Bo Yang Yu, Biotransformation of tetrahydroprotoberberines by Panax ginseng hairy root culture, Journal of Molecular Catalysis B: Enzymatic 2014,110, 133–139.

  3. Chen Hui Du, Jian Zhang*, Shao Hua Xu, Xu Dong Wang, Jun Ping Kou, Bo Yang Yu, Exploring the glycosylation capabilities of Gliocladium deliquescens NRRL 1086 on hydroxyl benzophenones, Journal of Molecular Catalysis B: Enzymatic, 2014, 99, 85– 88.

  4. Hai-Xia Ge, Ling Chen, Jian Zhang*, Jun-Ping KouBo-Yang Yu*. Inhibitory effect of curcumin analogs on tissue factor procoagulant activity and their preliminary structure–activity relationships, Medicinal Chemistry Research,   2013, 22(7), 3242-3246.

  5. Hai-Xia Ge, Jian Zhang*, Ling Chen,Jun-Ping KouBo-Yang Yu. Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorganic & Medicinal Chemistry. 2013,21, 62–69.

  6. Hai-Xia Ge, Jian Zhang, Ying Dong, Kai Cui, Bo-Yang Yu, Unique biocatalytic resolution of racemic tetrahydroberberrubine via kinetic glucosylation and enantio-selective sulphation. Chemical Communications, 201248, 6127-6129.

  7. Hai-Xia Ge, Jian Zhang*, KaiCui, Ji-Hua Liu, Bo-Yang Yu*. Regio- and enantio-selective glycosylation of  tetrahydroproto berberines by Gliocladium deliquescens NRRL1086 resulting the unique alkaloidal glycosides. Applied Microbiology and Biotechnology, 2012, 93 (6) , 2357-2364.