Release date:2016-05-23  Release:

Dawei Deng, PH.D.

Professor,Director of Department of Biomedical Engineering,

NewCentury Excellent Talents in University of the Ministryof Education of China (2012)

Department of Biomedical Engineering,

School of Engineering,

China Pharmaceutical University,

Nanjing, 210009,

P. R. China,

Cell phone: +86 13851476049


Date & Place of Birth: Nov. 11, 1979 in Nanjing, China

Short Research Description:

Molecular optical imaging and monitoring treatment response of diseases.

Accurate and rapid detection of tumors is of great importance for assessing the molecular basis of cancer pathogenesis, preventing disease complications, and implementing a tailored therapeutic regimen. For these reasons, we design and develop new molecular probes and nanomaterials (fluorescent quantum dots, Fe3O4 nanocrystals, et al.) for imaging the expression of aberrant genes, proteins, and other pathophysiologic processes. To utilize optical methods for cellular and in vivo imaging by optical methods, we focus on developing materials that are fluorescent in the near infrared wavelength region (700–900 nm) of the electromagnetic spectrum where light can penetrate deep in thick tissue. Specific delivery of the contrast agents to target cell organelles or tissue is accomplished by linking the agents to bioactive molecules such as peptides, proteins, and drugs. Alternatively, the inherent chemical properties of the contrast agents provide a mechanism to monitor cell trafficking or physiological processes such as tissue hypoxia and ion transport in cells.

Education and work history:

06-2015now: Professor, Department of Biomedical Engineering, China Pharmaceutical University. The research interests are focused on the syntheses of inorganic or organic near-infrared nanomaterials and their bioapplications.

06-201307-2014: Visiting scholar, Department of Chemical Engineering,University of Michigan (Ann Arbor), USA. Supervisor: Prof. Nicholas A. Kotov.

12-200706-2015: LecturerAssociate professor, Department of Biomedical Engineering, China Pharmaceutical University.

06-201006-2012: Postdoctor, State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.Supervisor: Prof. Zhongze Gu.

07-201108-2011: Institute for Biological and Medical Imaging, Munich Technical University, German. Supervisor: Prof. Vasilis Ntziachristos.

09-200412-2007: Ph.D., School of Chemistry and Chemical Engineering, Nanjing University, Analytical chemistry. Title: “Preparation and characterization of water-soluble CdE (E=S, Se, Te) quantum dots, one-dimensional CdTe nanocrystals and variously shaped Se nanocrystals”.Supervisor: Prof. Junsheng Yu and Prof. Yi Pan.

09-200107-2004: M.S., School of Chemistry and Chemical Engineering, Jilin University, Analytical chemistry. Title: “Determination of Component of the OceanicMineral Samples by ICP AES”.

09-199707-2001: B.S., School of Chemistry and Chemical Engineering, Jilin University, Applied chemistry.

The selected main research projects undertaken in recent years:

1. Surface award fromthe National Natural Science Foundation of China (NSFC, No. 81371627)

Title: Visual monitoring tumor targeting of nanomicelles and controlled release of drug using biocompatible quantum dots.

Period: 2014.1~2017.12

Role:  Principal investigator (RMB, 700,000)

Agency: Chinese National Science Foundation Committee

2. The Program for NewCentury Excellent Talents in University of the Ministryof Education of China (No. NCET-12-0974)

Title: Visual imaging tumor targeting of nanomicelles using biocompatible quantum dots

Period: 2013.1~2015.12

Role:Principal investigator (RMB, 500,000)

Agency: The Ministryof Education of China

3. Surface award fromthe National Natural Science Foundation of China (NSFC, No. 30800257)

Title: Magnetic nanocrystals along with fluorescent quantum dots for the DNA analysis

Period: 2009.1~2011.12

Role:  Principal investigator (RMB, 200,000)

Agency: Chinese National Science Foundation Committee

Selected Representative Publications (2011-now):

12. Jie Wang, Rong Zhang, Fangjian Bao, Zhihao Han, Yueqing Gu*,Dawei Deng*, “Water-soluble Zn-Ag-In-Se quantum dots with bright and widelytunable emission for biomedical optical imaging”, RSC Advances, 2015, 5, 8858388589. (IF=3.84)

11. Dawei Deng, Yang Li(co-first author), Jianpeng Xue, Guanhua Ai, Jie Wang, Xin Li, Yueqing Gu*. “Gold nanoparticle-based beacon to detect STAT5b mRNA expression in living cells: a case optimized by bioinformatics–screen”, Int. J. Nanomedicine, 2015, 10, 32313244. (IF=4.4)

10. Dawei Deng,* Junsheng Yu,* “Spontaneous Transformation of CdSe Nanoparticles into Nonspherical Se Crystals: The Role of the Precursor Ligand”, Cryst. Growth Des.,2015, 15, 602609. (IF=4.9)

9.Dawei Deng,* Lingzhi Qu, Yueqing Gu*, “Near-infrared broadly emissive AgInSe2/ZnS quantum dots for biomedical optical imaging”, J. Mater. Chem. C, 2014, 2, 70777085. (IF=4.7).

8. Dawei Deng,* Lingzhi Qu, Jian Zhang*, Yuxiang Ma, Yueqing Gu*, “Quaternary Zn-Ag-In-Se Quantum Dots for Biomedical Optical Imaging of RGD-Modified Micelles”, ACS Appl. Mater. Interfaces, 2013, 5, 1085810865.(IF=6.7)

7. Dawei Deng,* Lingzhi Qu, Samuel Achilefu, Yueqing Gu*, Broad spectrum photoluminescence quaternary quantum dots for cell and animal imaging, Chem. Commun., 2013, 49 (82), 9494–9496. (IF=6.4)

6. Dawei Deng*,Lingzhi Qu, Yang Li, and Yueqing Gu*, Versatile Self-Assembly of Water-Soluble Thiol-Capped CdTe Quantum Dots: External Destabilization and Internal Stability of Colloidal QDs, Langmuir, 2013, 29, 10907–10914. (IF=4.2)

5. Dawei Deng, Dongyin Zhang, Yang Li, Samuel Achilefu, Yueqing Gu*, “Gold Nanoparticles Based Molecular Beacons for in vitro and in vivo Detection of the Matriptase Expression on Tumor”, Biosens. Bioelectron, 2013, 49, 216–221. (IF=5.5)

4. Dawei Deng*, Jie Cao, Lingzhi Qu, Samuel Achilefu*, Yueqing Gu*, “Highly luminescent water-soluble quaternary Zn-Ag-In-S quantum dots for tumor cell-targeted imaging”, Physical Chemistry Chemical Physics, 2013, 15, 50785083. (IF=3.9)

3. Changli Du, Dawei Deng (co-first author), Lingling Shan, Shunan Wan, Jie Cao, Junmei Tian, Samuel Achilefu*, Yueqing Gu*, “A pH-sensitive doxorubicin prodrug based on folate-conjugated BSA for tumor-targeted drug delivery”, Biomaterials, 2013, 34(12), 3087–3097. (IF=7.6)

2. Dawei Deng, Yuqi Chen, Jie Cao, Junmei Tian, Zhiyu Qian, Samuel Achilefu*, Yueqing Gu*, “High-Quality CuInS2/ZnS Quantum Dots for in vitro and in vivo Bioimaging”, Chemistry of Materials, 2012, 24(15), 3029–3037. (IF=8.3)

1. Dawei Deng, Jie Cao, Junfei Xia, Zhiyu Qian, Yueqing Gu,* Zhongze Gu,* and Walter John Akers, “Two-phase Approach to High Quality, Oil-soluble, Near-infrared-emitting PbS Quantum dots by Using Various Water-soluble Anion Precursors”, Eur. J. Inorg. Chem., 2011, 2422–2432. (IF=3.2)