JIANG, ZHENZHOU

Release date:2016-05-25  Release:


 

JIANG, ZHENZHOU

Associate Professor of Pharmacology

Institute of Pharmaceutical Sciences

Phone: 86-25-83271142

Email: jiangcpu@163.com

Research Summary

Prof. Jiang investigates the pathomechanism of cholestatic and hepatocellular injury in herbal induced liver disease (HILD), especially cholestasis caused by perturbation of hepatocyte polarization after treatment with two herbal, dioscorea bulbifera (DB) and Tripterygium wilfordii Hook F (TWHF) both in vitro and in vivo models. The goal of this project is to deepen our understanding of the molecular mechanism of HILD and find appropriate methods that could be able to predict herbal candidate hepatotoxicity in humans before the start of clinical phases.


Education

2008-           Ph.D., Pharmacology, China Pharmaceutical University

2001-2006       M.S., PharmacokineticsChina Pharmaceutical University

1993-1998       B.S., PharmacologyChina Pharmaceutical University


Academic Experience

2013-      Associate Professor of Molecular Pharmacology, National Drug Screening Laboratory, China Pharmaceutical University

1998-2012 Research Assistant of Molecular PharmacologyNational Drug Screening Laboratory, China Pharmaceutical University


Awards and Honors

2013   the 2nd Prize of Science and Technology Progress awarded, Ministry of Education, P.R. China

2006   the 1st Prize of Science and Technology Progress awarded, Jiangsu Province


Publications

  1. Li Xiaojie, Xu Zhimeng, Wang Shaojie, Guo Hongli, Dong Sizhe, Wang Tao, Zhang Luyong*, Zhenzhou Jiang*. Emodin ameliorates hepatic steatosis through endoplasmic reticulum–stress sterol regulatory element-binding protein 1c pathway in liquid fructose-feeding rats. Hepatology Research. 2016.3.[Epub ahead of print]

  2. Bashir A.Yousef, Hozeifa M.Hassan, Zhang Luyong*, Jiang Zhenzhou*. Anticancer Potential and Molecular Targets of Pristimerin: A mini-review. Curr Cancer Drug Targets. 2016 Jan 11. [Epub ahead of print]. IF 3.522

  3. Bashir A.Yousef, Mounia Guerram, Hozeifa M.Hassan, Aida M.Hamdi, Zhang Luyong *, Jiang Zhenzhou*. Pristimerin demonstrates anticancer potential in colorectal cancer cells by inducing G1 phase arrest and apoptosis and suppressing various pro-survival signaling proteins.ONCOLOGY REPORTS · 2016, 35: 1091-1100. IF 2.30 · 

  4. Bashir A Yousef, Hozeifa M. Hassan, Mounia Guerram, Aida M. Hamdi, Wang Bin, Zhang Luyong*, Jiang Zhenzhou*. Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells. Biomedicine & Pharmacotherapy. 2016, 79: 112–119. IF 2.023.

  5. Liu Runping, Li Xiaojiaoyang, Luo Lan, Qiang Xiaoyan, Phillip B. Hylemon, Jiang Zhenzhou*, Zhang Luyong*, Zhou Huiping*.Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate. Receptor 2 in a Human Cholangiocarcinoma Cell Line. J Biol Chem. 2015, 290(52):30988-1002. IF 4.573.

  6. Tian Chongchong#, Ding Pingping, Yuan Ziqiao, Li Han, Zhao Yanxia, Sun Lan, Guo Qingming, Wang Zhenzhong, Sun Lixin, Zhang Luyong *, Jiang Zhenzhou*. A novel dual EGFR/HER2 inhibitor KU004 induces cell cycle arrest and apoptosis in HER2-overexpressing cancer cells. Apoptosis. 2015, 20: 1599–1612. IF 3.685

  7. Wang Yurong, Wang Bin, Guerram, Mounai, Sun Li, Shi Wei, Tian Congcong, Zhu Xiong, Jiang Zhenzhou*, Zhang Luyong*. Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio. Oncotarget. 2015, 6(30): 29497-512. IF 6.359.

  8. Mounia Guerram, Jiang Zhenzhou*, Bashir Alsiddig Yousef, Aida Mejda Hamdi, Hozeifa Mohamed Hassan, Yuan Ziqiao, Luo Houwei, Zhu Xiong, Zhang Luyong*. The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways. Oncotarget. 2015, 6(26): 21865-77. IF 6.359

  9. Hozeifa M. Hassan, Guo Hongli, Bashir A. Yousef, Zhang Luyong*, Jiang Zhenzhou*. Hepatotoxicity mechanisms of isoniazid: A mini-review. Journal of Applied Toxicology. 2015, 35: 1427–1432. IF 2.982.

  10. Wang Xinzhi, Zhang Luyong*, Jiang Zhenzhou*. Helper T cell-mediated factors in drug-induced liver injury. Journal of Applied Toxicology. 2015, 35(7):695-700. IF 2.982.

  11. Mounia Guerram, Jiang Zhenzhou*, Sun Lixin, Zhu Xiong, Zhang Luyong*. Antineoplastic effects of deoxypodophyllotoxin, a potent cytotoxic agent of plant origin, on glioblastoma U-87 MG and SF126 cells. Pharmacological Reports. 2015, 67(2): 245–252. IF 1.928.  

  12. Wang Yurong#Xu Yuan#,  Jiang Zhenzhou*, Guerram Mounia, Wang Bin, Zhu Xiong, Zhang  Luyong*. Deoxypodophyllotoxin Induces G2/M Cell Cycle Arrest and Apoptosis in SGC-7901 Cells and Inhibits Tumor Growth in Vivo. MOLECULES. 2015, 20(1): 1661-1675. IF 2.416.

  13. Su YJ, Zhang Y, Chen M, Jiang ZZ*, Sun LX, Wang T and Zhang LY. Lipopolysaccharide exposure augments isoniazide-induced liver injury. Journal of Applied Toxicology. 2014, 34: 1436–1442. IF 3.174

  14. Wang T, Zhou ZX, Sun LX, Li X, Xu ZM, Chen M, Zhao GL, Jiang ZZ*, Zhang LY.* Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms. Acta Pharmacol Sin. 2014, 35(12):1527-36. IF 2.496

  15. Wang XZ#, Jiang ZZ#, Cao WP, Yuan ZQ, Sun LX, Zhang LY*. Th17/Treg imbalance in triptolide-induced liver injury. Fitoterapia. 2014; 93: 245–251. IF 2.345

  16. Tai T, Huang X, Su YW, Ji JZ, Su YJ,  Jiang ZZ*, Zhang LY*. Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats. Journa of Ethnopharmacology.2014; 152:358–363. IF 2.755

  17. Xinzhi WangZhenzhou Jiang*,  Mengtao XingJing FuYuwen SudLixin SunLuyong Zhang*. Interleukin-17 mediates triptolide-induced liver injury in mice. Food and Chemical Toxicology. 2014, 71: 33–41. IF 2.61

  18. Xiao-Jiaoyang, Zhen-Zhou Jiang*, Lu-yongZhang. Triptolide: Progress on research in pharmacodynamics and toxicology. Journal of Ethnopharmacology. 2014, 155(1): 67-79.  IF 2.755

  19. Jing FuChongchong TianMengtao XingXinzhi WangHongli GuoLixin SunLan SunZhenzhou Jiang*, Luyong Zhang*. KU004 induces G1 cell cycle arrest in human breast cancer SKBR-3 cells by modulating PI3K/Akt pathway. Biomedicine & Pharmacotherapy. 2014, 68: 625-630 IF 2.108

  20. WANG Yun#, JIANG Zhen-Zhou#, CHEN Mi, WU Mei-Juan, GUO Hong-Li, SUN Li-Xin, WANG Hao, ZHANG Shuang, WANG Tao, ZHANG Lu-Yong*. Protective effect of total flavonoid C-glycosides from Abrus mollis extract on lipopolysaccharide-induced lipotoxicity in mice. Chinese Journal of Natural Medicines. 2014, 12(6): 469-476.

  21. Jiang ZZ, Wu MJ, Miao JS, Duan HQ, Zhang S, Chen M, Sun LX, Wang YR, Zhang XJ, Zhu X, Zhang LY. Deoxypodophyllotoxin exerts both anti-angiogenic and vascular disrupting effects. The International Journal of Biochemistry & Cell Biology. 2013; 45: 1710– 1719.  IF 4.634

  22. Jiang ZZ, Bao QL, Sun LX, Huang X, Wang T, Zhang S, Li H,Zhang LY. Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity.Toxicology and Applied Pharmacology. 2013; 266: 198–203.IF 4.447

  23. Wang JY, Jiang ZZ*, Ji JZ, Wang XZ, Chen M, Tai T, Zhang LY*. Gene expression profiling reveals potential key pathway involved in triptolide induced hepatotoxicity in Wistar rats. Food and Chemical Toxicology. 2013; 58: 495–505. IF 3.01

  24. Zhang Y, Jiang ZZ*, Su YJ, Chen M, Li F, Liu L, Sun LX, Wang Y, Zhang S, Zhang LY*. Gene expression profiling reveals potential key pathways involved in pyrazinamide-mediated hepatotoxicity in Wistar rats.Journal of Applied Toxicology. 2013; 33: 807–819.IF 2.478

  25. Meijuan Wu#, Zhenzhou Jiang#, Huaqin Duan, Lixin Sun, Shuang Zhang, Mi Chen, Yun Wang, Qin Gao, Yuming Song, Xiong Zhu* and Luyong Zhang*. Deoxypodophyllotoxin triggers necroptosis in human non-small cell lung cancer NCI-H460 cells. Biomedicine & Pharmacotherapy. 2013,67: 701-706. IF 2.108

  26. Sun LX, Li H, Huang X, Wang T, Zhang S, Yang J, Huang S, Mei HF, Jiang ZZ*, Zhang LY*. Triptolide alters barrier function in renal proximal tubular cells in rats. Toxicology Letters. 2013; 223: 96 -102. IF 3.145

  27. Mounia G, Jiang ZZ*, Zhang LY*. Podophyllotoxin, a medicinal agent of plant origin: past, present and future. Chinese Journal of Natural Medicines. 2012;10(3): 0161−0169. SCIE

  28. Mu XM, Shi W, Sun LX, Li H, Wang Y, Jiang ZZ*, Zhang LY*. Pristimerin inhibits breast cancer cell migration by up-regulating regulator of G protein signaling 4 expression.Asian Pacific Journal of Cancer Prevention.2012;(13):1097-1104.IF 0.659

  29. Mu XM, Shi W, Sun L, Li H, Jiang ZZ*and Zhang LY*. Pristimerin, a Triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation.Molecules.2012;(17): 6854-6868.IF 2.386

  30. Wang DC, Tang F, Wang S, Jiang ZZ*,Zhang LY*. Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor.Cancer Chemotherapy and Pharmacology.2012;(69):173–183.IF 2.833

  31. Xue M#, Jiang Z#, Wu T, Li J, Zhang L, Zhao Y, Li X, Zhang L*,  Yang S*. Anti-inflammatory effects and hepatotoxicity of  Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in rats.Phytomedicine.2012; (19): 998– 1006.IF 3.268

  32. Zhang J, Liu L, Mu XM, Jiang ZZ*andZhang LY*. Effect of triptolide on estradiol release from cultured rat granulosa cells.Endocrine Journal.2012;59(6): 473-481.IF 2.027

  33. Zhang Y, Jiang ZZ*, Xue M, Zhang S, Wang YR, Zhang LY*. Toxicogenomic analysis of the gene expression changes in rat liver after a 28-day oral Tripterygium wilfordii multiglycoside exposure.Journal of Ethnopharmacology.2012;(141): 170– 177.IF 3.014

  34. Zhang J, Jiang ZZ*, Mu XM, Wen J, Su YW, Zhang LY*.Effect of triptolide on progesterone production from cultured rat granulosa cells.Arzneimittelforschung.2012;62: 301–306.IF 0.691

  35. Fu Q, Huang X, Shu B, Xue M, Zhang PH, Wang T, Liu L, Jiang ZZ*, Zhang LY*. Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury. Fitoterapia. 2011; 82(8): 1241-1248.IF1.848