LIAO, HONG

Release date:2016-05-25  Release:


 

LIAO, HONG

Professor of Pharmacology

Institute of Pharmaceutical Sciences

Phone: 86-25-83271043

Email: hliao@cpu.edu.cn

Research Summary

Professor LIAO’s research focuses on: (1) the molecular and cellular mechanisms of glia in the central nervous system disease, such as stroke, trauma and Alzheimer’s disease. (2) The evaluation and drug screening for natural compounds affecting neurodegeneration disease. Glia are very important cells in the nervous system and involve in pathogenesis and pathophysiology of many CNS disorders. Our group just explore the effects of some molecules expressed on the glia on the CNS disorders, such as NgR (Nogo receptor), p75NTR, CD200,etc.

Education

2004       Ph.D., Pharmacology, China Pharmaceutical University

1990       M.S.,   Physiology, Nanjing University

1987       B.S.,   Physiology, Nanjing University

Academic Experience

2005-2016   Professor of Pharmacology, China Pharmaceutical University

2002-2005Research Scientist of Neurobiology, Singapore General Hospital

1990-2002  Associate Professor of Pathophysiology, Nanjing University

Awards and Honors

2014       Third / The science and technology progress prize of the Ministry of Education (the second award): new drug screening core technology standardization platform construction and its scientific application.  


Publications

[1]1: Li C, Wang J, Fang Y, Liu Y, Chen T, Sun H, Zhou XF, Liao H*. NafamostatMesilate Improves Function Recovery after Stroke by Inhibiting Neuroinflammation in Rats. Brain Behav Immun. 2016 Mar 23. pii: S0889-1591(16)30063-0.

[2]Wang J, Li C, Chen T, Fang Y, Shi X, Pang T, Zhang L, Liao H*. Nafamostatmesilate protects against acute cerebral ischemia via blood-brain barrierprotection. Neuropharmacology. 2016 Feb 6;105:398-410.

[3].Fang Y, Yao L, Li C, Wang J, Wang J, Chen S, Zhou XF, Liao H*. The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaquesand tau phosphorylation in APP/PS1 transgenic mice. J Neuroinflammation. 2016 Mar 3;13(1):56.

[4].Fang Y, Yan J, Li C, Zhou X, Yao L, Pang T, Yan M, Zhang L, Mao L, Liao H* The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory Activation.  J Biol Chem. 2015 Nov 27; 290(48):28901-14.

[5].Liu H, Dai X, Cheng Y, Fang S,Zhang Y, Wang X, Zhang W, Liao H, Yao H, Chao J#: MCPIP1 mediates silica-induced cell migration inhuman pulmonary fibroblasts. Am J Physiol-Lung C. 2015;

[6].Gao Y, Xu X, Chang S, Wang Y, Xu Y, Ran S, Huang Z, Li P, Li J, Zhang L, Saavedra JM, Liao H*, Pang T*.  Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):142-54.

[7].Liu GX, Ni J, Mao L, Yan M, Pang T, Liao H*. Expression of Nogo receptor 1 in microglia during development and following traumatic brain injury. Brain Research 2015, 162741-51

[8].Chen T, Wang J, Li C, Zhang L, An L, Pang T, Shi X, Liao H*  Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibition. Scientific Reports 2014 Jul 2;4:5531.

[9].Mei Liu, Jingjing Guo, Juan Wang, Luyong Zhang, Tao Pang* (共同通讯), Hong Liao*. Bilobalide induces neuronal differentiation of P19 embryonic carcinoma cells via activating Wnt/β-catenin pathway. Cell. Mol. Neurobiol. 2014, 34: 913-923.

[10].Liu FY, Wang YJ, Yan M, Zhang LY, Pang T*, Liao H*. Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons. Neurosci. Lett. 2013, 557: 90-94.

[11].Guo J, Wang J, Liang C, Yan J, Wang Y, Liu G, Jiang Z, Zhang L, Wang X, Wang Y, Zhou X, Liao H*. proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro. Stem Cell Res. 2013 ;11:874-87.

[12].Guo J, Wang J, Zhang Z, Yan J, Chen M, Pang T, Zhang L, Liao H*. proNGF inhibits neurogenesis and induces glial activation in adult mouse dentate gyrus. Neurochem Res. 2013;38:1695-703

[13].Sun J, Fang Y, Chen T, Guo J, Yan J, Song S, Zhang L, Liao H*  WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination; Brain Res. 2013 23;1491:225-35.

[14].Sun J, Fang YQ, Ren H, Chen T, Guo JJ, Yan J, Song S, Zhang LY, Liao H*  WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats; Acta Pharmacol Sin. 2013 ;34(1):119-28.

[15].Yan J, Zhou X, Guo J, Mao L, Wang Y, Sun J, Sun L, Zhang L, Zhou X, Liao H* Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro. J Neurochem.2012,120:721-731

[16].Wong I, Liao H, Bai XS, Zakan A, Zhong JH, Guan Y, Li HY, Wang YJ, Zhou XF  ProBDNF inhibits infiltration of ED+ macrophage after spinal cord injury  Brain, behaviour and Immunity  2010, 24585-597

[17].Liao H*, Huang W, Schachner M, Guan Y, Guo J, Yan J, Qin J, Bai X, Zhang L.beta 1 integrin mediated effects of tenascin-R domains EGFL and FN6-8 on neuralstem/progenitor cell  proliferation and differentiation in vitro. J. Biol. Chem. 2008, 283(41): 27927-27936

[18].Liao H*, Huang W, Niu R, Sun L, Zhang L. The cross-talk between Tenascin-R distinct domains EGFL/FN6-8 and microglia modulated neural stem cells proliferation and differentiation. J Neurosci Res. 2008, 86(1):27-34

[19].Liao H*, Bu W,  Wang T, Ahmed S, and Xiao ZC   Tenascin-R plays a role in neuroprotection via its distinct domains coordinately modulating the  microglia function.  J. Biol. Chem.  2005:  280(9)8316-8323   

[20].Tan XW, Liao H, Sun L, Masaru O, Xiao ZC and Dawe XW   Fetal Microchimerism in the Maternal Mouse Brain: A Novel Population of Fetal Progenitor or Stem Cells Able to Cross the Blood-Brain Barrier? Stem Cells,  2005, 23(10):1443-1452

[21].Liao H, Duka T, Teng FY, Sun L, Bu W, Ahmed S, Tang BL and  Z.C. Xiao  Nogo-66 and  myelin- associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells. J.Neurochem 2004,  90(5)115662