Sensen Lin

Associate professor of pharmacology

612 New Hall, National New Drug Screen Lab, China Pharmaceutical University, Nanjing, China, 210009

86 25 83271340 (office)  

E-mail:chaphalss@126.com

RESEARCH SUMMARY

Metastasis is a hallmark of cancer. Although the regulation of cancer metastasis remains unclear, it is found that some tumor types usually colonize to particular organs. Cytokines in tumor environment, especially growth factors and chemokines, are key regulators that may provide unique advantages to support cancer metastasis. My laboratory studies how these cytokines are regulated in cancer.We have identified a number of chemokines that confer significant advantages to cancer cells to metastasize to distant organs. We have also established high-throughout screening methods to search for possible anti-metastatic drug candidates.

EDUCATION

POSITIONS AND EMPLOYMENT

1999-2002      Teaching Assistant, China Pharmaceutical University

2008-2009Research Assistant, China Pharmaceutical University

2010-present    Assistant/Associate professor, China Pharmaceutical University

PUBLICATIONS

1.Yu XW, Lin S, Du HZ, Zhao RP, Feng SY, Yu BY, Zhang LY, Li RM, Qian CM, Luo XJ, Yuan ST, Sun L.Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of egf receptor in vitro and in vivo.Oncotarget. 2016 Apr 20. doi: 10.18632/oncotarget.8843. [Epub ahead of print]

2. Li H, Sun L, de Carvalho EL, Li X, Lv X, Khan GJ, Semukunzi H, Yuan S, Lin S.DT-13, a saponin monomer of dwarf lilyturf tuber, induces autophagy and potentiates anti-cancer effect of nutrient deprivation.Eur J Pharmacol. 2016;781:164-72. 

3. Lin SS, Li FF, Sun L, Fan W, Gu M, Zhang LY, Qin S, Yuan ST.Marsdenia tenacissima extract suppresses A549 cell migration through regulation of CCR5-CCL5 axis, Rho C, and phosphorylated FAK.Chin J Nat Med. 2016;14(3):203-9.

4. Lin SS, Fan W, Sun L, Li FF, Zhao RP, Zhang LY, Yu BY, Yuan ST.The saponin DT-13 inhibits gastric cancer cell migration through down-regulation of CCR5-CCL5 axis.Chin J Nat Med. 2014;12(11):833-40.

5. Sun L, Yang Q, Wang P, Liu D, Liang W, Lin S, Yuan S.The influence of YS-1 on the Dll4-Notch1 signaling pathway.Acta Biochim Biophys Sin (Shanghai). 2014;46(1):56-64.

6. Sun L, Liu Y, Lin S, Shang J, Liu J, Li J, Yuan S, Zhang L.Early growth response gene-1 and hypoxia-inducible factor-1α affect tumor metastasis via regulation of tissue factor.Acta Oncol. 2013;52(4):842-51.

7. Fang D, Sun L, Lin S, Zhou L, Su N, Yu B, Yuan S. Vinorelbine inhibits angiogenesis and 95D migration via reducing hypoxic fibroblast SDF-1 secretion. Exp Biol Med (Maywood). 2012;237(9):1045-55. 

8. Zhu J, Sun L, Lin S, Zhao R, Zhou L, Fang D, Chen L, Liu J, Shi W, Zhang L, Yuan S. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. J Exp Clin Cancer Res. 2012 Mar 31;31:31. 

9. Lin SS, Wan SY, Sun L, Hu JL, Fang DD, Zhao RP, Yuan ST, Zhang LY.Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia. Cancer Sci. 2012; 103(5):904-12.

10. Zhou L, Sun L, Lin S, Fang D, Zhao R, Zhu J,Liu J, Chen L, Shi W, Yuan S, Zhu D. Inhibition of angiogenic activity of hypoxic fibroblast cell line MRC-5 in vitro by topotecan. Med Oncol. 2011; 28(1): 653-9.

11. Sun L, Lin S, Zhao R, Yu B, Yuan S, Zhang L. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor.Biol Pharm Bull. 2010; 33(7): 1192-8.

12. Liu J, Jiang Z, Xiao J, Zhang Y,Lin S, Duan W, Yao J, Liu C, Huang X, Wang T, Liang Z, Wang R, Zhang S, Zhang L, Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines, Phytomedicine 2009; 16(11):1006-13.

13. Lin SS, Sun L, Zhang YK, Zhao RP, Liang WL, Yuan ST, Zhang LY, Topotecan inhibits cancer cell migration by down-regulation of chemokine CC motif receptor 7 and matrix metalloproteinases, Acta Pharmacol Sin. 2009; 30(5):628-36.

14. Lin S, Sun L, Hu J, Wan S, Zhao R, Yuan S, Zhang L, Chemokine C-X-C motif receptor 6 contributes to cell migration during hypoxia, Cancer Lett. 2009; 28; 279(1):108-17.