LIU, JUN

Release date:2016-05-25  Release:


LIU, JUN

Associate Professor of Metabolism of pharmacology

School of Department of Pharmacy

Phone:025-83271043

Email: junliu@cpu.edu.cn

Research Summary

Associate Professor LIU’s research focuses on the metabolism of pharmacology and tumor immunology. She recently published a paper entitled "Non-redundant regulation of murine T cell responses by VISTA and PD-1 immune-checkpoints." which demonstrates the nonredundant role of VISTA that is distinct fromthe PD-1/PD-L1 pathway in controlling T-cell activation,which provide the rationale to concurrently target VISTA and PD-1 pathways for treating T-cell-regulated diseases such as cancer.


 

Education

2007-2011  Ph.D., Pharmacology, China Pharmaceutical University

2001-2003  M.S., BiochemistryCalifornia State University

1989-1994  B.S., Pharmacology of Traditional ChineseMedicineChina Pharmaceutical University

Academic Experience

2003-    Associate Professor of the center of new drug screening,China Pharmaceutical University

1998-2001  Reasearch Associate of Florida Medical School,University of Florid

1995-1996 Associate Professor of Chinese Academy of Sciences Shanghai Institute of Materia Medica

1994-1995 Assistant engineer of pharmaceutical factory of China Pharmaceutical University

Awards and Honors

2006  Research and application of new drug screening system,First prize of scientific and technological progress in Jiangsu Province

2013 Construction and scientific application of core technology standardization platform for newdrugscreening,

Second  prize of Science and technology progress of the Ministry of education

Publications

1. Jun Liu, Ying Yuan, Wenna Chen, Juan Putra, Arief A. Suriawinata, Austin D. Schen, Halli Miller, Indira Guleria, Richard J. Barth, Yina H. Huang, Li Wang. Non-redundant regulation of murine T cell responses by VISTA and PD-1 immune-checkpoints.  PNAS 2015, 112 (21): 6682-66873. (IF 9.674)

2. Li Wang, Isabella Le Mercier, Juan Putra, Wenna Chen, Jun Liu, et al. Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.  PNAS 2014, 111(41): 14846-51. (IF 9.674)

3. Xue Wang, Yupeng Chen, Daoud Waseem Hassan, Hongbin Sun, Jun Liu*. Combination Therapy with Oleanolic Acid and Metformin as a Synergistic Treatment for Diabetes. Journal of Diabetes Research. 2015, doi: 10.1155/2015/973287. (IF 2.164)

4. Xue Wang, Qian Lu, Dongsheng Yu, Yupeng Chen, Jing Shang, Luyong Zhang, Hongbin Sun, Jun Liu*. Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model. Chinese Journal of Natural Medicines 2015, 13(7): 0529−0534. (IF 1.114)

5. Jun Liu, Xue Wang, Yupeng Chen, Lifei Mao, Jing Shang, Hongbin Sun*, Luyong Zhang*. Maslinic acid modulates glycogen metabolism by enhancing the insulin signaling pathway and inhibiting glycogen phosphorylase. Chinese Journal of Natural Medicines 201412 (4): 0259−0265. (IF 1.114)

6. Liying, Zhang, Xiaojian Jia, Jizhe Dong, Dongyin Chen, Jun Liu*, Luyong Zhang, Xiaoan Wen*. Synthesis and Evaluation of Novel Oleanolic Acid Derivatives as Potential Antidiabetic Agents.  Chemical Biology & Drug Design 2014, 83, 297-305. (IF 2.485)

7. Liying Zhang, Yingxia Zhang, Jizhe Dong, Jun Liu*, Luyong Zhang, Hongbin Sun*. Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid. Bioorganic & Medicinal Chemistry Letters 2012, 22, 1036-1039. (IF 2.420)

8. Lei Zhang, Xiaojie Chen, Jun Liu, Qingzhang Zhu, Ying Leng, Xiaomin Luo, Hualiang Jiang, Hong Liu*. Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase. European journal of medicinal chemistry 2012, 58, 624-639. (co-first author)  (IF 3.447)

9. Jun Liu, Ting He, Qian Lu, Jing Shang, HB Sun, Luyong Zhang. Asiatic acid preserves beta mass and mitigates hyperglycemia in streptozocin-induced diabetic rats. Diabetes Metabolism Research and Reviews 2010, 26, 448-454. (IF 3.553)

10.  Jun Liu, Hongbin Sun, Weigang Duan, Luyong Zhang. Maslinic acid reduces blood glucose and body weight in KK-Ay mice. Biological & Pharmaceutical Bulletin 2007, 30, 2075-2078. (IF 1.828)

11.  Gary A. Visner, Fuhua Lu, Hailan Zhou, Jun Liu, Kristy Kazemfar, and Anupam Agarwal. Rapamycin Induces Heme Oxygenase-1 in Human Pulmonary Vascular Cells: Implications in the Antiproliferative Response to Rapamycin. Circulation 2003, 107, 911–916. (IF 14.430)