PANG,​ TAO

Release date:2016-05-25  Release:

 


PANG, TAO

Specially-Appointed Professor of Pharmacology

Institute of Pharmaceutical Sciences

New Drug Screening Center

Phone: 86-25-83271043

E-mail: tpang@cpu.edu.cn


Research Summary

Dr. Pangs research focuses on the discovery of novel compounds by high-throughput screening or high-content screening in terms of molecular target-based assay or phenotypic assay, and drug development in order to provide therapeutics for the cerebral ischemic stroke and diabetes. He is also interested in the molecular mechanisms involved in brain inflammation, in order to prevent neuroinflammation and neuronal death, and promote brain functional recovery during cerebral ischemia.


Education

2007       Ph.D., Pharmacology, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences

2004       M.S., Biochemistry and Molecular BiologyEast China Normal University

2001       B.S., Applied BiologyJiangsu Normal University


Academic Experience

2016-      Specially-Appointed Professor of Pharmacology, China Pharmaceutical University

2012-2015  Associate Professor of Pharmacology, China Pharmaceutical University

2008-2012  Visiting Fellow, National Institute of Mental Health, National Institutes of Health (USA)

2007-2008  Postdoctoral Fellow, Johns Hopkins University (USA)


Awards and Honors

2007       Presidents Excellent Award, Chinese Academy of Sciences

2015-2016  Tony B. Travel Award, Society for Laboratory Automation and Screening (USA)


Publications

  1. Yuan Xu, Yazhou Xu, Yurong Wang, Yunjie Wang, Ling He, Zhenzhou Jiang, Zhangjian Huang, Hong Liao, Jia Li, Juan M. Saavedra, Luyong Zhang*, Tao Pang*. Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation. Brain Behav. Immun. 2015, 50: 298-313.

  2. Yuanxue Gao, Xiaojun Xu, Sai Chang, Yunjie Wang, Yazhou Xu, Siqi Ran, Zhangjian Huang, Ping Li, Jia Li, Luyong Zhang, Juan M. Saavedra, Hong Liao*, Tao Pang*. Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction. Toxicol. Appl. Pharmacol. 2015, 289(2): 142-154.

  3. Ying-Ying Wang, Yuan-Xue Gao, Wei Gao, Yuan Xu, Ya-Zhou Xu, Yun-Jie Wang, Sai Chang, Li-Gang Yu, Lu-Yong Zhang, Hong Liao, Lian-Fang Yang, Tao Pang*, Wen-Wei Qiu*. Design, synthesis andbiological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury. Eur. J. Med. Chem. 2015, 103: 396-408.

  4. Yazhou Xu, Yunjie Wang, Yuan Xu, Jia Li, Hong Liao*, Luyong Zhang*, Tao Pang*. Development of a novel phosphorylated AMPK protection assay for high-throughput screening using TR-FRET assay. J. Biomol. Screen. 2015, 20(7): 906-912.

  5. Qing Ye, Qiu Li, Yubo Zhou, Lei Xu, Weili Mao, Yuanxue Gao, Chenhui Li, Yuan Xu, Yazhou Xu, Hong Liao, Luyong Zhang, Jianrong Gao*, Jia Li*, Tao Pang*. Synthesis and evaluation of 3-(furo[2,3-b]pyridin-3-yl)-4-(1H-indol-3-yl)-maleimides as novel GSK-3β inhibitors and anti-ischemic agents. Chem. Biol. Drug Des. 2015, 86(4): 746-752.

  6. Qing Ye, Weili Mao, Yubo Zhou, Lei Xu, Qiu Li, Yuanxue Gao, Jing Wang, Chenhui Li, Yazhou Xu, Yuan Xu, Hong Liao, Luyong Zhang, Jianrong Gao*, Jia Li*, Tao Pang*. Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3β inhibitors and neuroprotective agents. Bioorg. Med. Chem. 2015, 23(5): 1179-1188.

  7. Tao Chen, Jing Wang, Chenhui Li, Weining Zhang, Luyong Zhang, Lufan An, Tao Pang*, Xinzhong Shi*, Hong Liao*. Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibition. Sci. Rep. 2014, 4: 5531.

  8. Juan Wang#, Tao Pang#, Roman Hafko#, Julius Benicky, Enrique Sanchez-Lemus, Juan M. Saavedra*. Telmisartan ameliorates glutamate-induced neurotoxicity: Roles of AT1 receptor blockade and PPARγ activation. Neuropharmacology. 2014, 79: 249-261.

  9. Xiaofeng Bao*, Yanyan Jin, Xiaolu Liu, Hong Liao, Luyong Zhang, Tao Pang*. Synthesis and biological evaluation of XB-1 analogues as novel histamine H3 receptor antagonists and neuroprotective agents. RSC Adv. 2014, 4: 6761-6775.

  10. Tao Pang*, Juan Wang, Julius Benicky, Enrique Sanchez-Lemus, Juan M. Saavedra. Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways. J. Neuroinflammation.2012, 9:102.

  11. Tao Pang*, Julius Benicky, Juan Wang, Martina Orecna, Enrique Sanchez-Lemus, Juan M. Saavedra. Telmisartan ameliorates lipopolysaccharide-induced innate immune response through PPARγ activation in human monocytes. J. Hypertens.2012, 30(1):87-96.

  12. Tao Pang*, Juan Wang, Julius Benicky, Juan M. Saavedra. Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition. Biochim. Biophys. Acta. 2012, 1820(4):503-510.

  13. Julius Benicky*, Enrique Sanchez-Lemus, Masaru Honda, Tao Pang, Martina Orecna, Juan Wang, Yan Leng, De-Maw Chuang, Juan M. Saavedra. Angiotensin II AT(1) receptor blockade ameliorates brain inflammation. Neuropsychopharmacology. 2011, 36(4):857-870.

  14. Bei-Ying Qiu, Nigel Turner, Yuan-Yuan Li, Min Gu, Meng-Wei Huang, Fang Wu, Tao Pang, Fa-Jun Nan, Ji-Ming Ye, Jing-Ya Li*, Jia Li*. High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice. Diabetes. 2010, 59(1):256-265.

  15. Ignacio M. Larrayoz#, Tao Pang#, Julius Benicky, Jaroslav Pavel, Enrique Sanchez-Lemus, Juan M. Saavedra*. Candesartan reduces the innate immune response to lipopolysaccharide in human monocytes. J. Hypertens. 2009, 27(12):2365-2376.

  16. Tao Pang, Zhen-Shan Zhang, Min Gu, Bei-Ying Qiu, Li-Fang Yu, Peng-Rong Cao, Wei Shao, Ming-Bo Su, Jing-Ya Li, Fa-Jun Nan*, Jia Li*. Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J. Biol. Chem.2008, 283(23):16051-16060.

  17. Tao Pang, Bing Xiong, Jing-Ya Li, Bei-Ying Qiu, Guo-Zhang Jin, Jin-Kang Shen, Jia Li*. Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. J. Biol. Chem.2007, 282(1):495-506.