Release date:2016-05-25  Release:


Associate professor of pharmacology

Institute of Pharmaceutical Research

Phone: 86-25-83271057


Research Summary

Associate Professor Sun’s research focuses on the tumor microenvironment, extracellular matrix and cancer metastasis. Epithelial tumor metastasis is preceded by an accumulation of collagen cross-links that heighten stromal stiffness and stimulate the invasive properties of tumor cells. She recently published a paper entitled "Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of EGF receptor in vitro and in vivo" which have significant clinical implications for patients with tumor harboring high EGFR expression due to the possible high sensitivity of this regimen. She and her research group have published many SCI research articles on various cancer journals, such asOncotarget, ActaOncologica, Cancer Lett, J Clin Invest, Mol Cancer Res. et al.





MD Anderson Cancer Center




China pharmaceutical University




China pharmaceutical University



Clinical Medicine

Jiangsu University

Academic Experience


Associate professor of Pharmacology

China pharmaceutical University



National Drug Screening Center


Resident Physician

Mai-gaoqiao hospital


  1. Yu XW, Lin S, Du HZ, Zhao RP, Feng SY, Yu BY, Zhang LY, Li RM, Qian CM,   Luo XJ, Yuan ST*, Sun L*. Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of egf receptor in vitro and in vivo.Oncotarget. 2016 Apr 20. doi: 10.18632/oncotarget.8843.

  2. Li H, Sun L, de Carvalho EL, Li X, Lv X, Khan GJ, Semukunzi H, Yuan S, Lin S. DT-13, a saponin monomer of dwarf lilyturf tuber, induces autophagy and potentiates anti-cancer effect of nutrient deprivation.Eur J Pharmacol. 2016; 781: 164-72.

  3. Pankova D, Chen Y, Terajima M, Schliekelman MJ, Baird BN, Fahrenholtz M, Sun L, Gill BJ, Vadakkan TJ, Kim MP, Ahn YH, Roybal JD, Liu X, Parra Cuentas ER, Rodriguez J, Wistuba II, Creighton CJ, Gibbons DL, Hicks JM, Dickinson ME, West JL, Grande-Allen KJ, Hanash SM, Yamauchi M, Kurie JM*.  Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.Mol Cancer Res. 2016 Mar;14(3):287-95.

  4. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M*, Kurie JM*. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015 Feb 9. pii: 74725. doi: 10.1172/JCI74725.

  5. Wang Yurong, Wang Bin, Guerram, Mounai, Sun Li, Shi Wei, TianCongcong, Zhu Xiong, Jiang Zhenzhou*, Zhang Luyong*. Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho Aactivatio. Oncotarget. 2015, 6(30): 29497-512. doi: 10.18632/oncotarget.4985.  ISSN: 1949-2553.

  6. Sun L, Yang Q, Wang P, Liu D, Liang W, Lin S*, Yuan S*. The influence of YS-1 on the Dll4-Notch1 signaling pathway. ActaBiochimBiophys Sin. 2014 Jan;46(1):56-64.

  7. Lin SS, Fan W, Sun L*, Li FF, Zhao RP, Zhang LY, Yu BY, Yuan ST*. The saponin DT-13 inhibits gastric cancer cell migration through down-regulation of CCR5-CCL5 axis.Chin J Nat Med. 2014 Nov; 12(11):0833-0840.

  8. Sun L, Liu J, Lin SS, Shi WT, Zhu J, Liang G, Yuan ST*. Potent anti-angiogenic activity of B19--a mono-carbonyl analogue of curcumin. Chin J Nat Med. 2014 Jan;12(1):8-14.

  9. Ren-Ping Z, Sen-Sen L, Yuan ST, Yu BY, Bai XS, Sun L*, Zhang LY*. DT-13, a saponin of dwarf lilyturf tuber, exhibits anti-cancer activity by down-regulating C-C chemokine receptor type 5 and vascular endothelial growth factor in MDA-MB-435 cells, Chin J Nat Med. 2014 Jan; 12(1): 0024-0029.

  10. Sun L,Liu Y,Lin S,Shang J,Liu J,Li J,Yuan S*,Zhang L*. Early growthresponse gene-1 and hypoxia-inducible factor-1α affect tumor metastasis via regulation of tissue factor. Acta Oncol.2013 May; 52 (4):842-851.

  11. Dong W , Li Y, Li X, Hu M, Aodengqimuge, Sun L, Guo N, Yuan S*, Song L*. p85α mediates NFAT3-dependent VEGF induction in the cellular UVB response. J cell Sci. 2013 Mar 15; 126(Pt 6):1317-1322.

  12. R Zhao, L Sun, S Lin, X Bai, B Yu, ST Yuan*, LY Zhang*. The saponin monomer of dwarf lilyturf tuber, DT-13, inhibits angiogenesis under hypoxia and normoxia via multi - targeting activity Oncology Reports, 2013/4. 29(4), 1379-1386.

  13. Koumtebaye E, Sun N, Hu WF, Lin SS, Sun L*, Yuan ST*. Antitumor activety of Xiaoaiping injection on human gastric cancer SGC-7901 cells. Chin J Nat Med. 2012, 10(5): 0339−0346, 10(5), 339-346.

  14. Fang D, Sun L, Lin S, Zhou L, Su N, Yuan S*, Yu B*. Vinorelbine inhibits angiogenesis and 95D migration via reducing hypoxic fibroblast stromal cell-derived factor 1 secretion. Exp Biol Med. 2012 Sep; 237 (9): 1045 - 1055.

  15. Lin S, Wan S, Sun L, Hu J, Fang D, Zhao R, Yuan S*, Zhang L*. Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia. Cancer Sci. 2012 May; 103(5):904-912.

  16. Zhu J, Sun L, Lin S, Zhao R, Zhou L, Fang D, Chen L, Liu J, Shi W, Zhang L, Yuan S*. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. J Exp Clin Cancer Res. 2012 Mar 31;31:31. doi: 10.1186/ 1756-9966 -31.

  17. Jiang W, Kou J, Yuan S, Sun L, Yu B*. A simplified and high-throughput chromogenic assay for testing tissue factor-dependent procoagulant activity. J Biomol Screen. 2011 Mar; 16 (3):295-302.

  18. Zhou L, Sun L, Lin S, Fang D, Zhao R, Zhu J, Liu J, Chen L, Shi W, Yuan S*, Zhu D*. Inhibition of angiogenic activity of hypoxic fibroblast cell line MRC-5 in vitrobytopotecan. Med Oncol. 2010 Nov 9

  19. Li Sun,Sensen Lin,Renping Zhao,Boyang Yu,Shengtao Yuan*,and Luyong Zhang*. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor. Biol. Pharm. Bull. 2010, 33(7) 1192-1198.

  20. Sun Li, Lin SS, Yu BY, Yuan ST*, Zhang LY*. High-throughput screening model for tissue factor inhibitor and effect of DT-13 on anti-tumor metastasis. Chin J Nat Med. Nov. 2010 Vol. 8 No. 6 466-470.

  21. Lin S, Sun L, Hu J, Wan S, Zhao R, Yuan S, Zhang L. Chemokine CXC motif receptor 6 contributes to cell migration during hypoxia. Cancer Lett. 2009 Jun 28; 279(1):108-17.

  22. Lin SS, Sun L, Zhang YK, Zhao RP, Liang WL, Yuan ST, Zhang LY. Topotecan inhibits cancer cell migration by down-regulation of chemokine CC motif receptor 7 and matrix metalloproteinases,Acta Pharmacologica Sinica. 2009 May; 30(5):628-36.

  23. Sun li, Fang al. 4-Hydroxyisoleucine improves glucose metabolism and insulin signal transduction in hepG-2 cells. Drug Development Research. 2006; (66):234.

  24. Sun li. Dai dezai. Inhibition of optical isomers of CPU86017 on vascular smooth muscle contraction caused by Ca2+. Chinese journal of natural medicines. 2006; 4(6): 456-9.