SUN, LIXIN

Release date:2016-05-25  Release:

 

SUN, LIXIN

Associate Professor of pharmacology

Institute of Pharmaceutical Research

Phone: 86-25-83271342

Email: slxcpu@126.com

Research Summary

Dr.SUN’s research focuses on the Chinese Herbal Medicine-induced toxicity, especially hepatotoxicity and nephrotoxicity. The imbalance of immune response induces the toxicity of Tripterygium wilfordii Hook F (TWHF). But there are only a few studies about the immune response in liver. Kupffer cells (KCs) are resident macrophages of the liver and play an important role in some drug induced-hepatotoxicity. Now we are investigating the pathomechanism of hepatotoxicity caused by perturbation of KCs polarization after treatment with triptolideboth in vitro and in vivo. The goal of this project is to provide vigorous experimental data for the clinical application of TWHF and provid a potential therapeutic target for hepatotoxicity induced by TWHF.


Education

2013       Ph.D., Pharmacology, China Pharmaceutical University

2004       M.S., Biochemistry and Molecular BiologyEast China Normal University

2000       B.S., Medical ChemistryChina Pharmaceutical University

Academic Experience

2014-   Associate Professor of pharmacology,Jiangsu Key Laboratory ofDrug Screening, Institute of Pharmaceutical Research

2004-2013  Senior Research Scientist of pharmacologyJiangsu Key Laboratory ofDrug Screening, Institute of Pharmaceutical Research

Publications

1.  Han Li, Guofeng Pan, Zhen-zhou Jiang, Jing Yang, Lixin Sun* and Lu-yong Zhang, Triptolide inhibits MCF-7 cell growth via estrogen receptor-α-related pathways. Acta Pharmacologica Sinica, 36, 606-613, 2015 (Corresponding author)

2.  Lixin Sun, Han Li, Xin Huang, Tao Wang, Shuang Zhang, Jing Yang, Shan Huang, Huifang Mei, Zhenzhou Jiang, Luyong Zhang*, Triptolide alters barrier function in renal proximal tubular cells in rats, Toxicology letters, 223(1), 96-102, 2013

3Zhenzhou Jiang, Qingli Bao, Lixin Sun* , Xin Huang, Tao Wang, Shuang Zhang, Han Li,  Luyong Zhang*, Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity, Toxicology and applied pharmacology, 266(2), 198-203, 2013(Corresponding author)

4.  Lixin Sun, Shuang Zhang, Zhenzhou Jiang, Xin Huang, Tao Wang, Xiao Huang, Han Li, Luyong Zhang*, Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-α-treated A549 cells, Biochemical and biophysical research communications, 416(1-2), 99-105, 2011