WANG, TAO

Release date:2016-05-25  Release:



WANG, TAO

Associate Professorof Pharmacology

Institute of Pharmaceutical Research

Phone: 86-25-83271043

Email: wangtao1331@126.com

Research Summary

Dr. Wang’s research focuses on new drug R&D and mechanism study for type 2 diabetes and metabolic disease. Using various molecular assays, cell-based assays and type 2 diabetic animal models, he has been investigating dozens of substances, obtaining from artificial synthesis, Traditional Chinese Medicine, and marine life. Dr. Wang is also interested in the molecular mechanisms underlining type 2 diabetes, with particular, in mitochondrial plasticity and skeletal muscle glucose metabolismrelated pathway.


Education

2014       Ph.D., Integrated traditional Chinese and Western Medicine, China Pharmaceutical University

2004       M.S., Pharmacology, China Pharmaceutical University

2001       B.S., bio-pharmaceuticals, China Pharmaceutical University

Academic Experience

2015-      Associate Professor of Pharmacology, China Pharmaceutical University

2004-2015  Assistant Professor of PharmacologyChina Pharmaceutical University

Awards and Honors

2005      Third Prize, for Natural Science Papers, Nanjing Science and Technology Committee

2013      Second Prize, for Scientific and technological progress, Chinese Ministry of Education

2014      Third Prize, for Scientific and technological progress, Xinjiang Uygur Autonomous Region


Publications

1.Xu ZM, Zhang LY, Li X, Jiang ZZ, Sun LX, Zhao GL, Zhou GH, Zhang H, Shang J*, Wang T*.    Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose-induced hepatic mitochondrial dysfunction.   Acta Biochim Biophys Sin (Shanghai). 201547(9):730-40.

2. HN ShenXU YuanZZ JiangX HuangLY ZhangT Wang*.  Inhibitory effects of Tripterygium wilfordii multiglycoside on benign prostatic hyperplasia in rats.  Chinese Journal of Natural Medicines. 2015, 13(06):421-427.

3. Wang T, Zhou ZX, Sun LX, Li X, Xu ZM, Chen M, Zhao GL, Jiang ZZ*, Zhang LY*. The protective role of resveratrol against α-naphthylisothiocyanate induced acute cholestasis: involvement of choleretic and anti-inflammatory mechanisms. Acta Pharmacologica Sinica. 2014, 46: 738–748.

4. Li X, Xu ZM, Jiang ZZ, Sun LX, Ji JZ, Miao JS, Zhang XJ, Li XJ, Huang S, Wang T*, Zhang LY*. Hypoglycemic effect of catalpol on high-fat diet/ streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis. Acta Biochim Biophys Sin. 2014, 46: 738–748.

5.  Chen M, Wang T, Jiang ZZ, Shan C, Wang H, Wu MJ, Zhang S, Zhang Y, Zhang LY*. Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollisextracts. Chin J Nat Med. 2014, 12(8):590-598.

6. Shi D*, Guo S, Jiang B, Guo C, Wang T, Zhang L, Li J.  HPN, a synthetic analogue of bromophenol from red alga Rhodomela confervoides: synthesis and anti-diabetic effects in C57BL/KsJ-db/db mice.  Mar Drugs. 2013,  11(2):350-62.

7. Jiang Z, Bao Q, Sun L*, Huang X, Wang T, Zhang S, Li H, Zhang L*. Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity. Toxicol Appl Pharmacol.  2013,  266:198-203.

8. Wang J, Jiang Z, Ji J, Li Y, Chen M, Wang Y, Zhang Y, Tai T, Wang T*, Zhang L*.  Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of Fructus Psoraleae. Journal of Ethnopharmacology. 2012,  1441:73-81

9. Shi D * , Li J, Jiang B, Guo S, Su H, Wang T.   Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties  Bioorganic & Medicinal Chemistry Letters. 2012,  222827–2832.

10.  Fu Q, Huang X, Shu B, Xue M, Zhang P, Wang T, Liu L, Jiang Z, Zhang L*.  Inhibition of mitochondrialrespiratory chain is involved in triptolide-induced liver injury.  Fitoterapia. 2011,  82(8):1241-8.

11. Zhou Z, Wang T, Jiang Z, Shang J, Liu L , Zhang Y, Zhu D   , Huang X, Zhang S, Hu Y, Wang J, Zhang L*.  Beneficial effects of colchicine on 17β–ethynylestradiol induced cholestasis in rats. Arzneimittel-Forschung  2011,  613):173-179  

12. Wu X, Zhang L, Gurley E, Studer E, Shang J, Wang T, Wang C, Yan M, Jiang Z, Hylemon PB, Sanyal AJ, Pandak WM Jr, Zhou H. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways.  Hepatology.  200847(6):1905-15