ZHANG, LUYONG

Release date:2016-05-25  Release:

ZHANG, LUYONG

Professor of pharmacology

Dean of science and technology office

Director of National Nanjing New Drug Screening Center of China Pharmaceutical University

Institute of Pharmaceutical Research

Phone: 86-25-83271023

Email: lyzhang@cpu.edu.cn

Research Summary

Specialist in pharmacology, toxicology and drug screening. Prof. Zhang's one interest is to develop new drugs related to major and frequently-occurring diseases among Chinese populations, the other is to study the pharmacological and toxicological mechanisms of TCMs for safe clinical usage. Prof. Zhang and his research team have been supported by more than 30 government grants in the past 5 years mainly concerning mechanisms and prediction of herb-induced liver injury. Prof. Zhang and his team have finished 63 applications for patents in the past 5 years and published more than 140 SCI papers.


Education

2000-2004  Ph.D., Pharmacology, China Pharmaceutical University

1996      Senior visiting scholar, new drug research center of Janssen Research Foundation. in Belgium

1986-1989  M.S., Pharmacology, China Pharmaceutical University

1979-1983  B.A., Pharmaceutical science China Pharmaceutical University


Academic Experience

2002-      Director of new drug screening center of China Pharmaceutical University and Jiangsu drug efficacy research and evaluation service center

2000-2002 In charge of pharmacology and toxicology division in National drug approving center of State food and drug administration

1996-2002 Associate director of new drug research center in China Pharmaceutical University

1996 Senior visiting scholar in Janssen Research Found

1993-1995 Associate Prof. of physiology department

1990-1993 Lecturer and laboratory manager of physiology department of China Pharmaceutical University

1986-1989 Laboratory manager in cardiovascular division of China Pharmaceutical University

1983-1986 R.A. in physiology department of Nanjing Pharmaceutical College


Awards and Honors

2014  Top Ten Person in TCM Award, Jiangsu Province

2013the 2nd Prize of Science and Technology Progress awarded, Ministry of Education, P.R. China

2010  “333” High-level Individual granted by the Dept. of Education, Jiangsu Province

2010  Advanced Individual granted by the Association of Science and Technology, Jiangsu Province

2009  the 8th outstanding natural science papers award of Nanjing

2009  the 2nd Prize of Science and Technology Progress awarded, Jiangsu Province,

2008  Young and Middle-aged Experts with Outstanding Contributions entitled by Jiangsu Province

2008  Talents Collective of Six Mega summit of Human resource awarded by Jiangsu Province

2007  “333” Honored person, Jiangsu provincial Party Committee Organization Department

2006  the 1st Prize of Science and Technology Progress awarded, Jiangsu Province

2005  the QinLan award for youth leaders, Jiangsu provincial Party Committee Organization Department

2004  New Century honored person award, Ministry of Education, P.R. China

2004  Young academic leaders of QingLan Project, Department of Education of Jiangsu Province

2004  Six Mega summit of Human resource award, Department of personnel of Jiangsu Province

2003  “333” High level Expert award, Department of Education of Jiangsu Province

1999  QinLan award for brilliant teachers, Department of Education of Jiangsu Province

1999  the first prize of basic study, State Administration of traditional Chinese Medicine


Publications

  1. Bashir A.Yousef, Mounia Guerram, Hozeifa M.Hassan, Aida M.Hamdi, Zhang Luyong *,  Jiang Zhenzhou*. Pristimerin demonstrates anticancer potential in colorectal cancer cells by inducing G1 phase arrest and apoptosis and suppressing various pro-survival signaling proteins. ONCOLOGY REPORTS · 2016, 35: 1091-1100. DOI: 10.3892/or.2015.4457

  2. Bashir A Yousef, Hozeifa M. Hassan, Mounia Guerram, Aida M. Hamdi, Wang Bin, Zhang Luyong*, Jiang Zhenzhou*. Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells. Biomedicine & Pharmacotherapy. 2016, 79: 112–119.

  3. Li Xiaojie, Xu Zhimeng, Wang Shaojie, Guo Hongli, Dong Sizhe, Wang Tao, Zhang Luyong*, Zhenzhou Jiang*. Emodin ameliorates hepatic steatosis through endoplasmic reticulum–stress sterol regulatory element-binding protein 1c pathway in liquid fructose-feeding rats. Hepatology Research. 2015. Online. doi: 10.1111/hepr.12538

  4. Bashir A.Yousef, Hozeifa M.Hassan, Zhang Luyong*, Jiang Zhenzhou*. Anticancer Potential and Molecular Targets of Pristimerin: A mini-review. Curr Cancer Drug Targets. 2016 Jan 11. [Epub ahead of print].

  5. Liu Runping, Li Xiaojiaoyang, Luo Lan, Qiang Xiaoyan, Phillip B. Hylemon, Jiang Zhenzhou*, Zhang Luyong*, Zhou Huiping*. Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate. Receptor 2 in a Human Cholangiocarcinoma Cell Line. J Biol Chem. 2015, online. Doi: 10.1074/jbc.M115.668277

  6. Hu Jie, Yu Qinwei, Chen Xin, YAN Ming*, Zhang luyong*. Antagonistic effects of extracts from Artemisia rupetris L. and Leontopodium leontopodioides to CC chemokine receptor 2b evaluated by Aequorin assay. CJNM. 2016

  7. Liu Li, Zhang Jun, Wang Zhenlian, Xu Defeng, Jiang Zhenzhou, Wang Tao, Ju Wenzheng, Zhang Luyong*. Gender Differences in the Toxicokinetics of Triptolide after Single- and Multiple-dose Administration in Rats. Drug Res. 2015, 65(11): 602-6. DOI:10.1055/s-0034-1395676

  8. Tian Chongchong#, Ding Pingping, Yuan Ziqiao, Li Han, Zhao Yanxia, Sun Lan, Guo Qingming, Wang Zhenzhong, Sun Lixin, Zhang Luyong *, Jiang Zhenzhou*. A novel dual EGFR/HER2 inhibitor KU004 induces cell cycle arrest and apoptosis in HER2-overexpressing cancer cells. Apoptosis. 2015, 20: 1599–1612. doi: 10.1007/s10495-015-1164-7

  9. Hu Jie#, Yu Qinwei#, Zhao Fang, Ji Jinzi, Jiang Zhenzhou, Chen Xin, Gao Peng, Ren Yuran, Shao Shuai, Zhang Luyong*, Yan Ming*. Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells. Chemico-Biological Interactions. 2015; 240: 38-46. DOI: 10.1016/j.cbi.2015.08.004.

  10. Wang Xinzhi, Zhang Luyong*, Jiang Zhenzhou*. T-Helper cell-mediated factors in drug-induced liver injury. Journal of Applied Toxicology. 2015; 35(7):695-700. DOI:10.1002/jat.3115. ISSN:1099-1263

  11. Li Han#, Pan Guofeng#, Jiang Zhenzhou, Yang Jing, Sun Lixin*, Zhang Luyong*.  Triptolide inhibits human breast cancer MCF-7 cell growth via downregulation of the ERα-mediated signaling pathway. Acta Pharmacologica Sinica. 2015; 36(5): 606-613. DOI:10.1038/aps.2014.162

  12. Shen Hainan#, Xu Yuan#, Jiang Zhenzhou, Huang Xin, Zhang Luyong*, Wang Tao*. Inhibitory effects of TripTripterygium wilfordii multiglycoside on benign prostatic hyperplasia in rats. 2015; 13(6):421-427. DOI:10.1016/S1875-5364(15)30035-2

  13. Liu Runping, Zhang Luyong*, Yang Jing, Zhang Xiaoxuan,  Mikkelsen Ross, Song Shiyu, Zhou Huiping*. HIV Protease Inhibitors Sensitize Human Head and Neck Squamous Carcinoma Cells to Radiation by Activating Endoplasmic Reticulum Stress. PloS one. 2015, 10(5):e0125928. DOI:10.1371/journal.pone.0125928. ISSN:1932-6203

  14. Wang Cuifen#, Dai Xiaoniu#, Liu Hua,  Yi Hongwei,  Zhou Dongrui, Liu Chunhui,  Ma Min, Jiang  Zhenzhou,  Zhang Luyong*. Involvement of PPAR gamma in emodin-induced HK-2 cell apoptosis. TOXICOLOGY IN VITRO. 2015, 29(1): 228-233. DOI: 10.1016/j.tiv.2014.10.021. ISSN: 0887-2333

  15. Wang Yurong#, Xu Yuan#,  Jiang Zhenzhou*, Guerram Mounia, Wang Bin, Zhu Xiong, Zhang  Luyong*. Deoxypodophyllotoxin Induces G2/M Cell Cycle Arrest and Apoptosis in SGC-7901 Cells and Inhibits Tumor Growth in Vivo. MOLECULES. 2015, 20(1): 1661-1675. DOI: 10.3390/molecules20011661. ISSN: 1420-3049

  16. Mounia Guerram,  Jiang Zhenzhou*, Sun Lixin, Zhu Xiong, Zhang Luyong*. Antineoplastic effects of deoxypodophyllotoxin, a potent cytotoxic agent of plant origin, on glioblastoma U-87 MG and SF126 cells. Pharmacological Reports. 2015, 67(2): 245–252. DOI: 10.1016/j.pharep.2014.10.003, ISSN: 1734-1140

  17. Chen Xin, Miao Jingshan, Wang Hao, Zhao Fang, Hu Jie, Gao Peng, Wang Yue, Zhang Luyong*, Yan Ming*. The anti-inflammatory activities of Ainsliaea fragrans Champ. extract and its components in lipopolysaccharide-stimulated RAW264.7 macrophages through inhibition of NF-kappa B pathway. JOURNAL OF ETHNOPHARMACOLOGY.2015; 170: 72-80. DOI: 10.1016/j.jep.2015.05.004. ISSN: 0378-8741

  18. Xu Zhimeng, Zhang Luyong*, Li Xiaojie, Jiang Zhenzhou, Sun Lixin, Zhao Guolin, Zhou Guohua, Zhang Heran, Shang Jing, Wang Tao*. Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose-induced hepatic mitochondrial dysfunction. Acta Biochimica et Biophysica Sinica. 2015; 47(9): 730-740. DOI:10.1093/abbs/gmv061. ISSN:1745-7270

  19. Xu Yazhou, Wang Yunjie, Xu Yuan, Li Jia, Liao Hong*, Zhang Luyong*, Pang Tao*.  Development of a Novel Phosphorylated AMPK Protection Assay for High-Throughput Screening Using TR-FRET Assay. JOURNAL OF BIOMOLECULAR SCREENING. 2015; 20(7):906-912. DOI: 10.1177/1087057115585471. ISSN: 1087-0571

  20. Mounia Guerram, Jiang Zhenzhou*, Bashir Alsiddig Yousef, Aida Mejda Hamdi, Hozeifa Mohamed Hassan, Yuan Ziqiao, Luo Houwei, Zhu Xiong, Zhang Luyong*. The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways. Oncotarget. 2015, 6(26): 21865-77.

  21. Wang Yurong, Wang Bin, Guerram, Mounai, Sun Li, Shi Wei, Tian Congcong, Zhu Xiong, Jiang Zhenzhou*, Zhang Luyong*. Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio. Oncotarget. 2015, 6(30): 29497-512. doi: 10.18632/oncotarget.4985.  ISSN: 1949-2553

  22. Hozeifa M. Hassan, Guo Hongli, Bashir A. Yousef, Zhang Luyong*, Jiang Zhenzhou*. Hepatotoxicity mechanisms of isoniazid: A mini-review. Journal of Applied Toxicology. 2015, 35: 1427–1432. DOI 10.1002/jat.3175

  23. Yuan Xu, Yazhou Xu, Yurong Wang, Yunjie Wang, Ling He, Zhenzhou Jiang, Zhangjian Huang, Hong Liao, Jia Li, Juan M. Saavedra, Luyong Zhang*, Tao Pang*. Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation. Brain Behav. Immun. 2015, 50: 298-313. DOI:10.1016/j.bbi.2015.07.015

  24. Chen Ming-Ming, Yin Zhi-Qi, Zhang Lu-Yong*, Liao Hong*. Quercetin promotes neurite growth through enhancing intracellular cAMP level and GAP-43 expression. Chinese journal of natural medicines. 2015, 13(9): 667-72. DOI:10.1016/S1875-5364(15)30064-9. 出版年:2015-Sep

  25. Chen Tao#, Wang Juan#, Liu Mei, Zhang Lu-Yong*, Liao Hong*. Screening of natural compounds with neuronal differentiation promoting effects in a cell-based model.作者: Chinese journal of natural medicines. 2015,13(8): 602-8.  DOI: 10. 1016 / S1875 - 5364(15)30056-X.

  26. Xu Yazhou, Wang Yunjie, Xu Yuan, Li Jia, Liao Hong*, Zhang Luyong*, Pang Tao*. Development of a Novel Phosphorylated AMPK Protection Assay for High-Throughput Screening Using TR-FRET Assay. JOURNAL OF BIOMOLECULAR SCREENING. 2015, 20(7): 906-912.DOI: 10.1177/1087057115585471.

  27. Liu Runping, Li Xiaojiaoyang, Jiang Zhenzhou, Phillip Hylemon, Huiping Zhou*, Luyong Zhang*. Taurocholate Induces Cyclooxygenase-2 Through Sphingosine 1-Phosphate Receptor 2 and Promotes Cholangiocarcinoma Cell Growth. Gastroenterology. 2015, 148(4):S-1013. DOI:10.1016/S0016-5085(15)33460-0 ·

  28. Li Xiaojiaoyang, Liu Runping, Jiang Zhenzhou*, Zhang Luyong*. 17α-Ethynylestradiol Impair Hepatocytes Polarity in Cholestasis via AMPK-Induced Suppression of Farnesoid X Receptor. Gastroenterology. 2015, 148(4):S-1013. DOI:10.1016 / S0016 - 5085(15)33459-4.

  29. Ji, Jin-zi; Lao, Ke-jing; Hu, Jie; Pang, Tao; Jiang, Zhen-zhou; Yuan, Hao-liang; Miao, Jing-shan; Chen, Xin; Ning, Shan-shan; Xiang, Hua; Guo, Yu-meng; *Yan, Ming; Zhang, Lu-yong*. Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay. Acta Pharmacologica Sinica, 2014, 35(8): 1082-1092.

  30. Chen M, Wang T, Jiang ZZ, Shan C, Wang H, Wu MJ, Zhang S, Zhang Y, Zhang LY*. Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollisextracts. Chin J Nat Med. 2014, 12(8): 590-598.  

  31. Wang T, Zhou ZX, Sun LX, Li X, Xu ZM, Chen M, Zhao GL, Jiang ZZ*, Zhang LY.* Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms. Acta Pharmacol Sin. 2014, 35(12):1527-36.

  32. Li X, Xu ZM, Jiang ZZ, Sun LX, Ji JZ, Miao JS, Zhang XJ, Li XJ, Huang S, Wang T*, Zhang LY*. Hypoglycemic effect of catalpol on high-fat diet/ streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis. Acta Biochim Biophys Sin. 2014, 46: 738–748.

  33. Xinzhi WangZhenzhou Jiang*,  Mengtao XingJing FuYuwen SudLixin SunLuyong Zhang*. Interleukin-17 mediates triptolide-induced liver injury in mice. Food and Chemical Toxicology. 2014, 71: 33–41.

  34. Wang XZ#, Jiang ZZ#, Cao WP, Yuan ZQ, Sun LX, Zhang LY. Th17/Treg imbalance in triptolide-induced liver injury. Fitoterapia. 2014; 93: 245–251.

  35. Tai T, Huang X, Su YW, Ji JZ, Su YJ,  Jiang ZZ*, Zhang LY*. Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats. Journa of Ethnopharmacology.2014; 152:358–363.

  36. Tao Pang#, Li-xin Sun#, Tao Wang, Zhen-zhou Jiang, Hong Liao* and Lu-yong Zhang*. Telmisartan protects central neurons against nutrient deprivation-induced apoptosis in vitro through activation of PPARγ and the Akt/GSK-3β pathway. Acta Pharmacologica Sinica. 2014, 35: 727–737.

  37. Jing FuChongchong TianMengtao XingXinzhi WangHongli GuoLixin SunLan SunZhenzhou Jiang*, Luyong Zhang*. KU004 induces G1 cell cycle arrest in human breast cancer SKBR-3 cells by modulating PI3K/Akt pathway. Biomedicine & Pharmacotherapy. 2014, 68: 625-630

  38. WANG Yun, JIANG Zhen-Zhou(共一作), CHEN Mi, WU Mei-Juan, GUO Hong-Li, SUN Li-Xin, WANG Hao, ZHANG Shuang, WANG Tao, ZHANG Lu-Yong*. Protective effect of total flavonoid C-glycosides from Abrus mollis extract on lipopolysaccharide-induced lipotoxicity in mice. Chinese Journal of Natural Medicines. 2014, 12(6): 469-476.  

  39. ZHAO Ren-Ping, LIN Sen-Sen, YUAN Sheng-Tao, YU Bo-Yang, BAI Xian-Shu, SUN Li*, LuYong ZHANG*. DT-13, a saponin of dwarf lilyturf tuber, exhibits anti-cancer activity by down-regulating C-C chemokine receptor type 5 and vascular endothelial growth factor in MDA-MB-435 cells. Chinese Journal of Natural Medicines 2014, 12(1): 24-29  

  40. Sun, L., Liu, Y., Lin, S., Shang, J., Liu, J., Li, J., Yuan, S.*, and Zhang, L.*. Early growth response gene-1 and hypoxia-inducible factor-1alpha affect tumor metastasis via regulation of tissue factor. Acta Onco. 2013; 52: 842-851.

  41. Zhao, R., Sun, L., Lin, S., Bai, X., Yu, B., Yuan, S.*, and Zhang, L*. The saponin monomer of dwarf lilyturf tuber, DT-13, inhibits angiogenesis under hypoxia and normoxia via multi-targeting activity. Oncology reports. 2013; 29: 1379-1386.  

  42. Zhenzhou Jiang, Meijuan Wu, Jingshan Miao, Huaqin Duan, Shuang Zhang, Mi Chen, Lixin Sun, Yurong Wang, Xueji Zhang, Xiong Zhu, Luyong Zhang*. Deoxypodophyllotoxin exerts both anti-angiogenic and vascular disrupting effects. The International Journal of Biochemistry & Cell BiologyINT J BIOCHEM CELL B. 45 (2013) 1710– 1719  

  43. Jiaying Wang, Zhenzhou Jiang*, Jinzi Jia, Xinzhi Wang, Mi Chen, Ting Tai, Luyong Zhang*. Gene expression profiling reveals potential key pathway involved in triptolide induced hepatotoxicity in Wistar rats. Food and Chemical Toxicology. 58 (2013) 495–505.

  44. Zhang Y, Jiang Z*, Su Y, Chen M, Li F, Liu L, Sun L, Wang Y, Zhang S, Zhang L*. Gene expression profiling reveals potential key pathways involved in pyrazinamide-mediated hepatotoxicity in Wistar rats.Journal of Applied Toxicology. 2013; 33: 807–819.

  45. Jiang Z, Bao Q, Sun L*, Huang X, Wang T, Zhang S, Li H, Zhang L*. Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity.Toxicology and Applied Pharmacology. 2013; 266: 198–203.

  46. Meijuan Wu, Zhenzhou Jiang, Huaqin Duan, Lixin Sun, Shuang Zhang, Mi Chen, Yun Wang, Qin Gao, Yuming Song, Xiong Zhu and Luyong Zhang*. Deoxypodophyllotoxin triggers necroptosis in human non-small cell lung cancer NCI-H460 cells. Biomedicine & Pharmacotherapy. 2013,67: 701-706.

  47. Lixin Sun, Han Li, Xin Huang, Tao Wang, Shuang Zhang, Jing Yang, Shan Huang, Huifang Mei, Zhenzhou Jiang*, Luyong Zhang*. Triptolide alters barrier function in renal proximal tubular cells in rats. Toxicology Letters. 2013, 223: 96 -102.

  48. H. Xin, J. Zhenzhou , T. Weiwei, X. Yi , Z. Luyong* , Z. Zunjian*. A Validated Method for Quantifying Entecavir in Biological Matrices and Its Application in a Pharmacokinetic Study in Rats and Dogs. Drug Res. 2013; 63: 644-649  

  49. Huang X, Jiang ZZ, Wang T, Z. Li , L. Y. Zhang* , Z. J. Zhang*. Pharmacokinetics, Distribution and Excretion of PNA in Rat by Liquid Chromatography Mass Spectrometry Method[J]. Drug Res. 2013, 63(10): 540-544.  

  50. Qin Gao, Xin Huang, Zhenzhou Jiang, Guanlan Liu, Yi Xiao, Lixin Sun, Tao Wang, Luyong Zhang*, Shaofei Xie, Haiyan Huang. A rapid and sensitive LC–ESI-MS/MS method for the detection of YF-49–92.MLS in rat plasma. Bioanalysis. 2013; 5(20): 2521–2530.

  51. Fu Qiang, Jiang Zhen-zhou, Zhang Lu-yong*. Impairment of triptolide on liver mitochondria in isolated liver mitochondria and HL7702 cell line . CHINESE JOURNAL OF INTEGRATIVE MEDICINE. 2013;19(9):   683-688  

  52. Mounia G, Jiang Z* , Zhang L*. Podophyllotoxin, a medicinal agent of plant origin: past, present and future..Chinese Journal of Natural Medicines. 2012;10(3): 0161−0169. SCIE  

  53. Guo J, Niu R, Huang W,Zhou M, Shi J, Zhang L*, Liao H*. Growth factors from tumor microenvironment possibly promote the proliferation of glioblastoma-derived stem-like cells in vitro. Pathology & Oncology Research.2012;(18):1047–1057.

  54. Hu G, Li F,  Ouyang K, Xie F, Tang X, Wang K,Han S, Jiang Z, Zhu M, Wen D, Qin X* and Zhang L*. Intrinsic gemcitabine resistance in a novel pancreatic cancer cell line is associated with cancer stem cell-like phenotype.International Journal of Oncology.2012;40: 798-806.  

  55. Li F, Hu G, Jiang Z, Guo J, Wang K, Ouyang K, Wen D, Zhu M,  Liang J, Qin X* and Zhang L*. Identification of NME5 as a contributor to innate resistance to gemcitabine in pancreatic cancer cells.The FEBS Journal. 2012; (279): 1261–1273.  

  56. Li F, Jiang Z, Wang K, Guo J, Hu G, Sun L, Wang T, Tang X, He L, Yao J, Wen D, Qin X* , Zhang L*. Transactivation of the human NME5 gene by Sp1 in pancreatic cancer cells.Gene. 2012; (503): 200–207.  

  57. Lin S,Wan S,Sun L,Hu J, Fang D, Zhao R, Yuan S*and Zhang L*. Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia.Cancer Science. 2012;103(5): 904–912.  

  58. Ma M, Jiang Z, Ruan J, Tan X, Liu J, Wang C,Zha X, Zhang L*. The furano norclerodane diterpenoid disobulbin-D induces apoptosis in normal human liver L-02 cells.Experimental and Toxicologic Pathology.2012; (64): 611– 618.  

  59. Mu X, Shi W, Sun L, Li H, Wang Y, Jiang Z*, Zhang L*. Pristimerin inhibits breast cancer cell migration by up-regulating regulator of G protein signaling 4 expression.Asian Pacific Journal of Cancer Prevention.2012;(13):1097-1104.  

  60. Mu X, Shi W, Sun L, Li H, Jiang Z* and Zhang L*. Pristimerin, a Triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation.Molecules.2012;(17): 6854-6868.

  61. Ping F, Shang J*, Zhou J, Song J, Zhang L*. Activation of neurokinin-1 receptor by substance P inhibits melanogenesis in B16-F10 melanoma cells. The International Journal of Biochemistry & Cell Biology. 2012;(44): 2342–2348.  

  62. Ping F, Shang J*, Zhou J, Zhang H, Zhang L*. 5-HT1A receptor and apoptosis contribute to interferon-γ-induced “depressive-like” behavior in mice.Neuroscience Letters.2012; (514): 173– 178.

  63. Su Y, Chen X., Jiang Z, Wang T, Wang C, Zhang Y, Wen J, Xue M, Zhu D, Zhang Y, Su Y, Xing T, Zhang C*, Zhang L*. A panel of serum microRNAs as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats.PLoS ONE.2012;7(5):1-11.

  64. Wang D, Jiang Z, Zhang L*. Concurrent and sequential administration of sunitinib malate and docetaxel in human non-small cell lung cancer cells and xenografts.Medical Oncology.2012; (29):600–606.

  65. Wang D, Tang F, Wang S, Jiang Z*, Zhang L*. Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor.Cancer Chemotherapy and Pharmacology.2012;(69):173–183.  

  66. Wang J, Jiang Z, Ji J, Li Y, Chen M, Wang Y, Zhang Y, Tai T, Wang T*, Zhang L*. Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract.Journal of Ethnopharmacology.2012; (144): 73–81.  

  67. Xue M, Jiang Z, Wu T, Li J, Zhang L, Zhao Y, Li X, Zhang L*, Yang S*. Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in rats.Phytomedicine.2012; (19): 998– 1006.  

  68. Zhang J, Liu L, Mu X, Jiang Z* and Zhang L*. Effect of triptolide on estradiol release from cultured rat granulosa cells.Endocrine Journal.2012;59(6): 473-481.  

  69. Zhang J, Jiang Z, Mu X, Wen J, Su Y, Zhang L*.Effect of triptolide on progesterone production from cultured rat granulosa cells.Arzneimittelforschung.2012;62: 301–306.

  70. Zhang Y, Huang X, Jiang Z, Huang X, Hu Y, Zhu D, Zhang S, Wang J and Zhang L*. Simultaneous determination of metacavir and its metabolites in rat plasma using highperformance liquid chromatography with tandem mass spectrometric detection (LCMS/MS).Biomedical Chromatography.2012;26:363–370.  

  71. Zhang Y, Jiang Z*, Xue M, Zhang S, Wang Y, Zhang L*. Toxicogenomic analysis of the gene expression changes in rat liver after a 28-day oral Tripterygium wilfordii multiglycoside exposure.Journal of Ethnopharmacology.2012;(141): 170– 177.  

  72. Li Z, Yan M, Li Z, Vuki M, Wu D, Liu F, Zhong W, Zhang L*, Xu D*. A multiplexed screening method for agonists and antagonists of the estrogen receptor protein.Analytical and Bioanalytical Chemistry.2012; (403):1373–1384.

  73. Zhou ZX, Wang T, Jiang ZZ, Shang J, Liu L, Zhang Y, Zhu D, Huang X, Zhang S, Hu Y, Wang JY, Zhang LY*. Beneficial effects of colchicine on 17alpha-ethynylestradiol-induced cholestasis in rats. Arzneimittel-Forschung 2011; 61(3): 173-179.  

  74. Zhang P, Zhang L*, Jiang Z, Xiong Y, Chen H, Tao Y, Hu M, Li Z. Evaluation of Mitochondrial Toxicity in Marmota himalayana Treated with Metacavir, a Novel 2',3'-Dideoxyguanosine Prodrug for Treatment of Hepatitis B Virus. Antimicrob Agents Chemother 2011; 55(5): 1930-1936.  

  75. Zhang L, Li J, Jiang Z, Sun L, Mei X, Yong B, Zhang L*. Inhibition of aquaporin-1 expression by RNAi protects against aristolochic acid I-induced apoptosis in human proximal tubular epithelial (HK-2) cells. Biochem Biophys Res Commun 2011; 405(1): 68-73.  

  76. Xue M, Jiang ZZ, Wu T, Yan M, Liu JP, Mu XM, Su YW, Zhang LY*. Protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats. Arzneimittel-Forschung 2011; 61(10): 571-576.  

  77. Sun L, Zhang S, Jiang Z, Huang X, Wang T, Li H, Zhang L*. Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-alpha-treated A549 cells. Biochem Biophys Res Commun 2011; 416(1-2): 99-105.  

  78. Liu L, Jiang Z, Huang X, Liu J, Zhang J, Xiao J, Bao Q, Wen J, Zhang S, Zhu D, Zhang P, Zhang L*. Disappearance of sexual dimorphism in triptolide metabolism in monosodium glutamate treated neonatal rats. Arzneimittel-Forschung 2011; 61(2): 98-103.

  79. Liu J, Sun H, Shang J, Yong Y, Zhang L*. Effect of olive pomace extracts on hyperlipidaemia. Nat Prod Res 2011; 25(12): 1190-1194.

  80. Liu J, Jiang Z, Liu L, Zhang Y, Zhang S, Xiao J, Ma M, Zhang L*. Triptolide induces adverse effect on reproductive parameters of female Sprague-Dawley rats. Drug Chem Toxicol 2011; 34(1): 1-7.

  81. Li J, Zhang L*, Zhou H, Stoneking M, Tang K. Global patterns of genetic diversity and signals of natural selection for human ADME genes. Hum Mol Genet 2011; 20(3): 528-540.  

  82. Fu Q, Huang X, Shu B, Xue M, Zhang P, Wang T, Liu L, Jiang Z, Zhang L*. Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury. Fitoterapia 2011; 82(8): 1241-1248.  

  83. Zhang P, Zhang L*, Jiang Z, Wang T, Chen H, Xiong Y, Li Z. In vitro mitochondrial toxicity of metacavir, a new nucleoside reverse transcriptase inhibitor for treatment of hepatitis B virus. Antimicrob Agents Chemother 2010; 54(11): 4887-4892.  

  84. Zhang H, Wang W, Jiang Z, Shang J, Zhang L*. Differential involvement of 5-HT(1A) and 5-HT(1B/1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test. Arzneimittel-Forschung 2010; 60(3): 109-115.

  85. Xue M, Jiang ZZ, Liu JP, Zhang LY*, Wang T, Wang H, Liu L, Zhou ZX. Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A. Fitoterapia 2010; 81(8): 1109-1112.  

  86. Sun L, Lin S, Zhao R, Yu B, Yuan S, Zhang L*. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor. Biological & pharmaceutical bulletin 2010; 33(7): 1192-1198.  

  87. Liu L, Jiang Z, Liu J, Huang X, Wang T, Zhang Y, Zhou Z, Guo J, Yang L, Chen Y, Zhang L*. Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats. Toxicology 2010; 271(1-2): 57-63.  

  88. Liu J, He T, Lu Q, Shang J, Sun H, Zhang L*. Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats. Diabetes Metab Res Rev 2010; 26(6): 448-454.  

  89. Li J, Zhang L*, Jiang Z, Shu B, Li F, Bao Q. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro 2010; 24(4): 1092-1097.  

  90. Huang FH, Zhang XY, Zhang LY*, Li Q, Ni B, Zheng XL, Chen AJ. Mast cell degranulation induced by chlorogenic acid. Acta pharmacologica Sinica 2010; 31(7): 849-854.  

  91. Wang H, Wu T, Yan M, Liu G, Li P, Zhang XQ, Ye WC, Zhang LY. Sesquiterpenes from Ainsliaea fragrans and their inhibitory activities against cyclooxygenases-1 and 2. Chemical & pharmaceutical bulletin 2009; 57(6): 597-599.

  92. Shu B, Duan W, Yao J, Huang J, Jiang Z, Zhang L. Caspase 3 is involved in the apoptosis induced by triptolide in HK-2 cells. Toxicol In Vitro 2009; 23(4): 598-602.

  93. Liu J, Jiang Z, Xiao J, Zhang Y, Lin S, Duan W, Yao J, Liu C, Huang X, Wang T, Liang Z, Wang R, Zhang S, Zhang L. Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines. Phytomedicine 2009; 16(11): 1006-1013.

  94. Lin SS, Sun L, Zhang YK, Zhao RP, Liang WL, Yuan ST, Zhang LY. Topotecan inhibits cancer cell migration by down-regulation of chemokine CC motif receptor 7 and matrix metalloproteinases. Acta pharmacologica Sinica 2009; 30(5): 628-636.

  95. Lin S, Sun L, Hu J, Wan S, Zhao R, Yuan S, Zhang L. Chemokine C-X-C motif receptor 6 contributes to cell migration during hypoxia. Cancer letters 2009; 279(1): 108-117.

  96. Li Z, Yao J, Zhang Z, Zhang L. Simultaneous determination of omeprazole and domperidone in dog plasma by LC-MS method. J Chromatogr Sci 2009; 47(10): 881-884.

  97. Duan WG, Shang J, Jiang ZZ, Yao JC, Yun Y, Yan M, Shu B, Lin Q, Yu ZP, Zhang LY. Rho kinase inhibitor Y-27632 down-regulates norepinephrine synthesis and release in PC12 cells. Basic Clin Pharmacol Toxicol 2009; 104(6): 434-440.

  98. Cheng Y, Zhang J, Shang J, Zhang L. Prevention of free fatty acid-induced hepatic lipotoxicity in HepG2 cells by magnesium isoglycyrrhizinate in vitro. Pharmacology 2009; 84(3): 183-190.

  99. Wu X, Zhang L, Gurley E, Studer E, Shang J, Wang T, Wang C, Yan M, Jiang Z, Hylemon PB, Sanyal AJ, Pandak WM, Jr., Zhou H. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. Hepatology (Baltimore, Md 2008; 47(6): 1905-1915.

  100. Wang W, Zhang Z, Shang J, Jiang ZZ, Wang S, Liu Y, Zhang LY. Activation of group I metabotropic glutamate receptors induces long-term depression in the hippocampal CA1 region of adult rats in vitro. Neuroscience research 2008; 62(1): 43-50.

  101. Wang C, Jiang Z, Yao J, Wu X, Sun L, Liu C, Duan W, Yan M, Sun L, Liu J, Zhang L. Participation of cathepsin B in emodin-induced apoptosis in HK-2 Cells. Toxicology letters 2008; 181(3): 196-204.

  102. Ni B, Zhu T, Jiang Z, Zhang R, Zhang T, Zhang L. In Vitro and in Silico Approaches for Analyzing the Toxicological Effect of Triptolide on Cx43 in Sertoli Cells. Toxicology Mechanisms and Methods 2008; 18(9): 717-724.

  103. Ni B, Jiang Z, Huang X, Xu F, Zhang R, Zhang Z, Tian Y, Wang T, Zhu T, Liu J, Zhang L. Male reproductive toxicity and toxicokinetics of triptolide in rats. Arzneimittel-Forschung 2008; 58(12): 673-680.

  104. Liao H, Huang W, Schachner M, Guan Y, Guo J, Yan J, Qin J, Bai X, Zhang L. Beta 1 integrin-mediated effects of tenascin-R domains EGFL and FN6-8 on neural stem/progenitor cell proliferation and differentiation in vitro. The Journal of biological chemistry 2008; 283(41): 27927-27936.

  105. Liao H, Huang W, Niu R, Sun L, Zhang L. Cross-talk between the epidermal growth factor-like repeats/fibronectin 6-8 repeats domains of Tenascin-R and microglia modulates neural stem/progenitor cell proliferation and differentiation. Journal of neuroscience research 2008; 86(1): 27-34.

  106. Li Z, Huang X, Jiang Z, Xiao Y, Liu C, Zhang L, Shu B, Huang J, Li T, Wang T, Wang F. A sensitive and specific liquid chromatography-mass spectrometry method for determination of metacavir in rat plasma. Journal of chromatography 2008; 864(1-2): 9-14.

  107. Yao JC, Duan WG, Yun Y, Liu de Q, Yan M, Jiang ZZ, Zhang LY. Screening method for nonsteroidal antiinflammatory drugs based on the cyclooxygenase 2 pathway activated by serum-free stimulation in A549 cells. Yakugaku Zasshi 2007; 127(3): 527-532.

  108. Wang C, Wu X, Chen M, Duan W, Sun L, Yan M, Zhang L. Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells. Toxicology 2007; 231(2-3): 120-128.

  109. Liu J, Sun H, Duan W, Mu D, Zhang L. Maslinic acid reduces blood glucose in KK-Ay mice. Biological & pharmaceutical bulletin 2007; 30(11): 2075-2078.

  110. Ling Z, Jiang ZZ, Huang X, Zhang LY, Xu XY. A liquid chromatography-mass spectrometry method for the quantitation of aristololactam-I in rat plasma. Biomed Chromatogr 2007; 21(1): 10-14.

  111. Jiao H, Xu F, Zhang Z, Tian Y, Jiang Z, Zhang L. Simultaneous determination of ZLR-8 and its active metabolite diclofenac in dog plasma by high-performance liquid chromatography. Biomed Chromatogr 2007; 21(4): 382-388.

  112. Yao J, Zhang L, Zhao X, Hu L, Jiang Z. Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry. Biological & pharmaceutical bulletin 2006; 29(7): 1483-1486.

  113. Yan M, Zhang LY, Sun LX, Jiang ZZ, Xiao XH. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. Journal of ethnopharmacology 2006; 107(2): 308-311.

  114. Li SL, Li P, Sheng LH, Li RY, Qi LW, Zhang LY. Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines. Journal of pharmaceutical and biomedical analysis 2006; 41(2): 576-581.

  115. Duan W, Zhang L. Cyclooxygenase inhibitors not inhibit resting lung cancer A549 cell proliferation. Prostaglandins, leukotrienes, and essential fatty acids 2006; 74(5): 317-321.

  116. Duan W, Wang S, Chen M, Wang C, Zhang L, Liu J, Sun L, Yan M. Harvest active recombinant Rho kinase from Escherichia coli. Biological & pharmaceutical bulletin 2006; 29(1): 38-42.

  117. Duan W, Sun L, Liu J, Wu X, Zhang L, Yan M. Establishment and application of a high throughput model for rho kinase inhibitors screening based on fluorescence polarization. Biological & pharmaceutical bulletin 2006; 29(6): 1138-1142.

  118. Duan W, Yu Y, Zhang L. Antiatherogenic effects of phyllanthus emblica associated with corilagin and its analogue. Yakugaku Zasshi 2005; 125(7): 587-591.