LIU, XIAOXUAN

Release date:2016-05-25  Release:

  

Xiaoxuan LIU received her Ph.D in 2010 from both Wuhan University in China and Aix-Marseille Univeristy in France. After her Ph.D, she joined the Cancer Research Center of Marseille and Interdisciplinary Center on Nanoscience of Marseillein France and performed research for around five years. During this period, she got two post-doctoral grants from l’Association pour la Recherche sur les Tumeurs de la Prostate (ARTP) and l’AssociationFrançaisecontre les Myopathies (AFM). On 2015, she was recruited as Specially-Appointed Professors by China Pharmaceutical University of Jiangsu Province. On 2016, she was selected by the Thousand Youth Talents Plan.

Her research interest is focus on developing multi-functional dendrimers as nanovectors for nucleic acid and drug delivery, which is interdisciplinary research programincluding chemistry, physics, biology and medicine. Originated from these research results, she has co-authored 25 publications such as AngewandteChemie International Edition, Proceedings of the National Academy of Sciences, Nanoscale, Nanomedicine: Nanotechnology, Biology and Medicine, and etc. Some of the results have been highlighted by Nature Chemistry and reported as frontispiece or cover story. She has participated in numerous conferences with invited oral communications and acted as reviewers for international journals such as ACS Nano, ACS Catalysis, Nanomedicine: NBM, New Journal of Chemistry, ChemBioChem and etc.


Research interest

1. Medicinal chemistry: dendrimer drug

2. Pharmaceuticals: dendrimer as gene and drug delivery system


Selected publications

  1.  Tuo Wei, Chao Chen, Juan Liu, Cheng Liu, Paola Posocco, Xiaoxuan Liu, Qiang Cheng, ShuaidongHuo, Zicai Liang, Maurizio Fermeglia, Sabrina Pricl, Xing-Jie Liang, Palma Rocchi, Ling Peng, “Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance”, Proc. Natl. Acad. Sci.2015, 112, 2978-2783. (IF : 9.67)

  2. Xiaoxuan Liu*,Cheng Liu, Jiehua Zhou, Chao Chen, FanqiQu,John J. Rossi,PalmaRocchi, Ling Peng*, “Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrimer”, Nanoscale2015, 7, 3867-3875. (IF : 7.394*co-corresponding authors)

  3. Xiaoxuan Liu, Jiehua Zhou, Tianzhu Yu, Chao Chen, Qiang Cheng, KheyaSengupta, Yuanyu Huang, Haitang Li, Cheng Liu, Yang Wang, Paola Posocco, Menghua Wang, Qi Cui, Suzanne Giorgio,Maurizio Fermeglia, Fanqi Qu, Sabrina Pricl, Yanhong Shi, Zicai Liang, Palma Rocchi, John J. Rossi, Ling Peng, “Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems”,Angew. Chem. Int. Ed.2014, 53, 11822-11827.(IF : 11.336) (Highlighted by Nature Chemistry)

  4. Xiaoxuan Liu, Cheng Liu, Carlo V. Catapano, Ling Peng, Jiehua Zhou, Palma Rocchi, “Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics”, Biotechnol. Adv. 2014, 32, 844-852. (IF : 9.015)

  5. Xiaoxuan Liu, Cheng Liu, Chao Chen, MélanieBentobji, Francine AzarioCheillan, Jeanne ThomassinPiana, Fanqi Qu, Palma Rocchi, Ling Peng, “Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system”,Nanomedicine:Nanotechnology, Biology and Medicine2014, 10, 1627-1636. (IF : 6.155)

  6. Cheng Liu, Xiaoxuan Liu*, Palma Rocchi, Fanqi Qu, Juan L. Iovanna, Ling Peng*, “An arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo”, Bioconjugate Chem. 2014, 25, 521-532. (IF : 4.513*co-corresponding authors)

  7.  Tianzhu Yu1, Xiaoxuan Liu1, Anne-Laure Bolcato-Bellemin, Yang Wang, Cheng Liu, Patrick Erbacher, Fangqi Qu, Palma Rocchi, Jean-Paul Behr, Ling Peng, “An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo”, Angew. Chem. Int. Ed. 2012, 51, 8478-8484. (IF : 11.3361co-furst authors) (Frontispiece)

  8. Xiaoxuan Liu, Cheng Liu, Erik Laurini, Paola Posocco, Sabrina Pricl, Fanqi Qu, Palma Rocchi, Ling Peng, “Efficient delivery of sticky siRNA and potent gene silencing in a prostate cancer model using a generation 5 triethanolamine-core PAMAM dendrimer”, Mol. Pharmaceutics 2012, 9, 470-481. (IF : 4.384Cover story)


Contact :

Emailxiaoxuanliucpu@163.com, xiaoxuanliu@cpu.edu.cn

Tel: 025-83271175