MO, RAN

Release date:2016-05-25  Release:

MO, RAN

Professor of Pharmaceutics

Institute of Pharmaceutical Science

Phone: 86-25-83271159

Email: rmo@cpu.edu.cn; rmocpu@163.com


Research Summary

Professor MO's research focuses on exploiting new strategies for precise drug delivery using stimuli-responsive systems in an on-demand manner for treatment of human diseases, including cancer and diabetes. These "smart" systems are integrated with the responsive modules that can be regulated by the disease-associated signals, such as acidity, enzymes, redox potential, reactive oxygen species, ATP and glucose, which can efficiently overcomemultiple physiological barriers and specifically deliver drugs to their targets for enhanced therapeutic efficacy and reduced toxicity.


Education

2012  Ph.D., Pharmaceutics, China Pharmaceutical University

2009  M.S., Pharmaceutics, China Pharmaceutical University

2006  B.S., Pharmaceutical Preparation, China Pharmaceutical University


Academic Experience

2014-present  Professor of Pharmaceutics, Center of Drug Discovery, Institute of Pharmaceutical Science, China Pharmaceutical University

2012-2014  Postdoctoral Associate, Joint Department of Biomedical Engineering/UNC Eshelman Pharmacy School, University of North Carolina at Chapel Hill and North Carolina State University


Awards and Honors

2015  Young Talents Lift Program, China Association of Science and Technology

2015  Distinguished Young Scholars, the Natural Science Foundation ofJiangsu Province of China, Science and Technology Department of Jiangsu Province of China

2015  Six Talent Peaks Project of Jiangsu Province, Science and Technology Department of Jiangsu Province of China

2014  Jiangsu Specially-Appointed Professors, Education Departmentof Jiangsu Province of China

2013  Excellent Ph.D. Thesis of Jiangsu Province, Education Departmentof Jiangsu Province of China

2012  Outstanding Award of Innovative Achievement Scholarship for Distinguished Students, Nanjing Sanhome Pharmaceutical Co., Ltd.

2012  Excellent Ph.D. Graduate of China Pharmaceutical University

2011  Triple-A Outstanding Student of China Pharmaceutical University

2010  Top-Notch Talent of China Pharmaceutical University


Publications

  1. Ran Mo*, Zhen Gu*, Tumor Microenvironment and Intracellular Signal-Activated Nanomaterials for Anticancer Drug Delivery, Mater. Today, 2016, in press, DOI: 10.1016/j.mattod.2015.11.025. (IF: 14.107)

  2. Qiong Sun, Zisheng Kang, Lingjing Xue, Yunkai Shang, Zhigui Su, Hongbin Sun, Qineng Ping, Ran Mo*, Can Zhang*, A Collaborative Assembly Strategy for Tumor-Targeted siRNA Delivery, J. Am. Chem. Soc., 2015, 137(18): 6000-6010. (IF: 12.113)

  3. Tianyue Jiang, Wujin Sun, Qiuwen Zhu, Nancy A. Burns, Saad A. Khan, Ran Mo*, Zhen Gu*, Furin-Mediated Sequential Delivery of Anticancer Cytokine and Small-Molecule Drug Shuttled by Graphene, Adv. Mater., 2015, 27(6): 1021-1028. (Cover Feature, IF: 17.493)

  4. Wujin Sun, Tianyue Jiang, Yue Lu, Margaret Reiff, Ran Mo*, Zhen Gu*, Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery, J. Am. Chem. Soc., 2014, 136(42): 14722-14725. (IF: 12.113)

  5. Caoyun Ju#, Ran Mo#,*, Jingwei Xue, Lei Zhang, Zekai Zhao, Lingjing Xue, Qineng Ping, Can Zhang*, Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration, Angew. Chem. Int. Ed., 2014, 53(24): 6253-6258. (Co-First Author, VIP Paper, Cover Feature, IF: 11.261)

  6. Ran Mo*, Tianyue Jiang, Zhen Gu*, Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery, Angew. Chem. Int. Ed., 2014, 53(23): 5815-5820. (IF: 11.261)

  7. Ran Mo, Tianyue Jiang, Rocco DiSanto, Wanyi Tai, Zhen Gu*, ATP-Triggered Anticancer Drug Delivery, Nat. Commun., 2014, 5: 3364. (Featured by Nature (homepage headline news), IF: 11.47)

  8. Tianyue Jiang#,Ran Mo#, Adriano Bellotti, Jianping Zhou*, Zhen Gu*, Gel-Liposome-Mediated Co-Delivery of Anticancer Membrane-Associated Proteins and Small-Molecule Drugs for Enhanced Therapeutic Efficacy, Adv. Funct. Mater., 2014, 24(16): 2295-2304. (Co-First Author, Cover Feature, IF: 11.805)

  9. Ran Mo, Tianyue Jiang, Jin Di, Wanyi Tai, Zhen Gu*, Emerging Micro- and Nanotechnology Based Synthetic Approaches for Insulin Delivery, Chem. Soc. Rev., 2014, 43(10): 3595-3629. (IF: 33.383)

  10. Ran Mo, Qiong Sun, Jingwei Xue, Nan Li, Wenyuan Li, Can Zhang*, Qineng Ping, Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery, Adv. Mater., 2012, 24(27): 3659-3665. (Cover Feature, IF: 14.829)