WEN, XIAOAN

Release date:2016-05-25  Release:



Xiaoan Wen is Associate Research Professor at China Pharmaceutical Universitys Center of Drug Discovery & Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases. His research interests are mainly centered in drug discovery for metabolic diseases and cancers. He gained his BE degree of Pharmaceutical Chemistry in 1998 and Ph. D degree of Medicinal Chemistry in 2007 at China Pharmaceutical University. Sponsored by the Foundation Franco-Chinoise pour la Science et ses Application (FFCSA) and the China Scholarship Council (CSC), he  received post-doctoral training between 2010-2012 at Lille 2 University of Health and Law’s Biostructures and Drug Discovery (INSERM U761) in France. From 1998-2002, he was employed as a scientific researcher by the Jiangsu Hansoh Pharmaceutical Co. Ltd. in China. Since 2007, he has being worked in China Pharmaceutical University.

Research Interest: drug discovery for metabolic diseases and cancers


Fundings

National Natural Science Foundation (No. 8147308 and 21002125)

Jiangsu Natural Science Foundation (BK20141355)

Ph.D. Programs Foundation of Ministry of Education of China (No. 20090096120009)

Awards & Honors

2009 National Excellent Doctoral Dissertation Award Nomination

2009 CPA-Servier Yong Investigator Awards in Medicinal Chemistry

  “Bioorganic & Medicinal Chemistry LettersMost Cited Paper 2006-2009 Award

Publications & Patents

  1. Xiaowei Sun, Xiaoan Wen (co-first author), Yan-yan Chen, Chen Shi, Chengzhe Gao, Yong Wu, Li-jun Wang, Xiu-hong Yang*, Hongbin Sun*. Discovery of highly potent renin inhibitors potentially interacting with the S3′ subsite of renin. European Journal of Medicinal Chemistry 2015, 103, 269-288.

  2. Chunhuan Jiang, Qinglong Xu, Xiaoan Wen*, Hongbin Sun*. Current developments in pharmacological therapeutics for chronic constipation. Acta Pharmaceutica Sinica B2015, 5(4), 300–309.

  3. Chunhong Li, Hongjin Du, Xiaoan Wen*, Hongbin Sun. Advances in inhibitors of MDM2 and MDM4. Journal of China Pharmaceutical University2015, 46 (1), 1-15.

  4. Chao Lin, Le Zhen, Yong Cheng, Hong-Jin Du, Hui Zhao, Xiaoan Wen, Lingyi Kong, Qing-Long Xu*,Hongbin Sun*. Visible-light Induced Isoindoles Formation to Trigger Intermocular Diels-Alder Reactions In the Presence of Air. Organic letters2015, 17, 2684–2687.

  5. Yong-Zhi Chang, Ming-Lei Li, Wen-Feng Zhao, Xiaoan Wen, Qing-Long Xu*. Construction of Oxadiazepines via Lewis Acid-Catalyzed Tandem 1,5-Hydride Shift/Cyclization. Journal of Organic Chemistry2015, 80, 9620-9627.

  6. Peng-Fei Wang, Ya-Ping Huang, Xiaoan Wen, Hongbin Sun*, Qing-Long Xu*. Concise Access to 1,2-Pyrrole-Annulated Benzazepines Through a Brønsted Acid Catalyzed Redox-Neutral Domino Reaction. European Journal of Organic Chemistry2015, 30, 6727-6733.

  7. Xiantao Lei, Hong-Yan Xie, Si-Yuan Chen, Kai-Shun Teng, Xiaoan Wen, Qing-Long Xu*, Hongbin Sun.*Approach to N-Aryl Pyrroles via Diphenyl Phosphate -catalyzed [1,5]-Hydride Shift/Isomerization Reaction with Indoles. Tetrahedron2015, 71, 4098–4101.

  8. Peng-Fei Wang, Chun-Huan Jiang, Xiaoan Wen, Qing-Long Xu,* Hongbin Sun.*C-H Bond Functionalization via [1,5]-Hydride Shift/Cyclization Sequence: Approach to Spiroindolenines. Journal of Organic Chemistry2015, 80, 1155-1162.

  9. Fan Zhang, Hengzhi Sun, Zhuang Song, Shuxi Zhou,Xiaoan Wen, Qing-Long Xu,* Hongbin Sun.*Stereoselective Synthesis of Arylglycine Derivatives via a Palladium-Catalyzed alpha-Arylation of Chiral Nickel (II) Glycinate.Journal of Organic Chemistry2015, 80, 4459−4464.

  10. Le Zhen, Chao Lin, Hong-Jin Du, Liang Dai, Xiaoan Wen, Qing-Long Xu*, Hongbin Sun.*Quinone Methides as [1,5]-Hydride Acceptors: Approach to N-Aryl Pyrroles.Tetrahedron2015, 71, 2839-2843.

  11. Xiantao Lei, Chun-Huan Jiang, Xiaoan Wen, Qing-Long Xu,* Hongbin Sun.* Formal [4 + 1] cycloaddition of o-quinone methides: facile synthesis of dihydrobenzofurans. RSC Adv.2015,5, 14953-14957.

  12. Zeng-Wei Lai, Chunhong Li, Jun Liu, Lingyi Kong, Xiaoan Wen*, Hongbin Sun*. Discovery of highly potent DPP-4 inhibitors by hybrid compounddesign based on linagliptin and alogliptin. European Journal of Medicinal Chemistry2014, 83, 547–560.

  13. Jizhe Dong, Yanchun Gong, Jun Liu, Xiangfeng Chen, Xiaoan Wen*, Hongbin Sun*. Synthesis and biological evaluation of all eight stereoisomersof DPP-IV inhibitor saxagliptin. Bioorganic & Medicinal Chemistry2014, 22, 1383–1393.

  14. Xiaowei Sun, ChengzheGao, Fan Zhang, Zhuang Song, Lingyi Kong,Xiaoan Wen*, Hongbin Sun*. Electronic and steric effects on the intramolecular Schmidt reactionof alkyl azides with secondary benzyl alcohols. Tetrahedron2014, 70, 643–649

  15. Dongyin Chen, Chang Xu, Jie Deng, Chunhuan Jiang, Xiaoan Wen, Lingyi Kong, Ji Zhang*, Hongbin Sun*. Proton-exchanged montmorillonite-mediated reactionsof methoxybenzyl esters and ethers. Tetrahedron2014, 70, 1975–1983.

  16. Liying Zhang, Xiaojian Jia, Jizhe Dong,Dongyin Chen, Jun Liu*, Luyong Zhang,Xiaoan Wen*. Synthesis and evaluation of novel oleanolic acid derivatives as potential antidiabetic agents. Chemical Biology & Drug Design2014, 83, 297–305.

  17. Jiao Hao, Jun Liu, Xiaoan Wen*, Hongbin Sun*.Synthesis and cytotoxicity evaluation of oleanolic acid derivatives. Bioorganic & Medicinal Chemistry Letters2013, 23, 2074-2077.

  18. Ben Niu, Xiaoan Wen, Zhijun Jia, Xiaoming Wu, Wanhua Guo*, Hongbin Sun*. Synthesis and preliminary evaluation of 1-[18F]fluoro-1-deoxy-2,5-anhydro-D-mannitol as a PET radiotracer for breast cancer imaging. Chinese Journal of Chemistry2013, 31, 1159-1163.

  19. Jiemei Song, Xiaoan Wen, Hongbin Sun*. Advances in research on a novel anticancer target USP7 and its inhibitors. Chinese Journal of Medicinal Chemistry2013, 23(6)486492.

  20. Jiemei Song, Xiaoan Wen, Hongbin Sun*. Progress in pathogenesis and therapeutic drugs of pulmonary arterial hypertension. Journal of China Pharmaceutical University2013, 44, 1-10.

  21. Xiaoan Wen, Jamal El Bakali, Rebecca Deprez-Poulain, Benoit Deprez. Efficient propylphosphonic anhydride (®T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles. Tetrahedron Letters2012, 53, 2440-2443.

  22. Zhongjie Liang, Liying Zhang, Lianchun Li, Jun Liu, Hongling Li, Luyong Zhang, Limin Chen, Keguang Cheng, Mingyue Zheng, Xiaoan Wen, Pu Zhang, Jia Hao, Yanchun Gong, Xia Zhang,Xiaoyun Zhu, Jun Chen, Hong Liu, Hualiang Jiang, Cheng Luo*, Hongbin Sun b*. Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.European Journal of Medicinal Chemistry2011, 46, 2011-2021.

  23. Xiaoan Wen, Jun Liu, Luyong Zhang, Peizhou Ni, Hongbin Sun*. Synthesis and biological evaluation of arjunolic acid, bayogenin, hederagonic acid and 4-epi-hederagonic acid as glycogen phosphorylase inhibitors. Chinese Journal of Natural Medicines2010, 8, 441-448.

  24. Xiaoan Wen,Yingxia Zhang, Jun Liu, Luyong Zhang, Peizhou Ni, Hongbin Sun*. Synthesis and bio logica lactivity o f heterocycle-fused derivatives of pentacylictriterpenes as glycogen phosphorylase inhibitors. Chinese Journal of Medicinal Chemistry2009, 40, 491-496.

  25. Xiaoan Wen, Hongbin Sun*, Jun Liu, Keguang Cheng, Pu Zhang, Liying Zhang, Jia Hao, Luyong Zhang, Peizhou Ni, Spyros E. Zographos, Demetres D. Leonidas, Kyra-Melinda Alexacou, Thanasis Gimisis, Joseph M. Hayes, Nikos G. Oikonomakos*. Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. Journal of Medicinal Chemistry2008, 51, 3540-3554.

  26. Jia Hao, Pu Zhang, Xiaoan Wen,Hongbin Sun*.Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid. Journal of Organic Chemistry 2008, 73, 7405-7408.

  27. Xiaoan Wen, Jun Xia, Keguang Cheng, Liying Zhang, Pu Zhang, Jun Liu, Luyong Zhang, Peizhou Ni and Hongbin Sun*. Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases. Bioorganic & Medicinal Chemistry Letters2007, 17, 5777-5782.

  28. Xiaoan Wen, Pu Zhang, Jun Liu, Luyong Zhang, Xiaoming Wu, Peizhou Ni and Hongbin Sun*. Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors. Bioorganic & Medicinal Chemistry Letters2006, 16, 722-726.

  29. Xiaoan Wen, Hongbin Sun*, Jun Liu, Guanzhong Wu, Luyong Zhang, Xiaoming Wu, Peizhou Ni.Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. Bioorganic & Medicinal Chemistry Letters2005, 15, 4944-4948.

  30. Hongbin Sun, Xiaoan Wen. A method for preparation of tetrabenazine. ZL201010017288.5.

  31. Hongbin Sun, Luyong Zhang, Yunman Li, Xiaoan Wen, Jun Chen, Jun Liu, Keguang Cheng, Weirong Fang, Miaomiao Hu, Teng Guan, Shixue Sun, Jingtiang Liu, Peizhou Ni, Weiyi Hua, Shanzhi Wang. Pharmaceutical use of pentacyclic triterpenes as glycogen phosphorylase inhihibitors. ZL200610067268.2.

  32. Hongbin Sun, Xiaoan Wen, Peizhou Ni. Methods for preparation of corosolic acid and maslinic acid. ZL200410069297.

Contacts

Tel/fax: 025-83271050.

E-mail: wxagj@126.com

Address: China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009